neurofilament light
Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration
... can identify cerebral amyloidosis with high accuracy (Jane- lidze et al. 2016; Nakamura et al. 2018). Furthermore, using the Simoa platform, plasma T-tau has been shown to be consistently elevated in AD (Mattsson et al. ...
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Neurofilament light chain level is a weak risk factor for the development of MS
... 5 neurofilament heavy chain; NfL 5 neurofilament light chain; OCB 5 oligoclonal bands; PBVC 5 percentage brain volume change; sema3A 5 semaphorin 3A; SIENA 5 Structural Image Evaluation, using ...
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Neurofilament light chain is a promising serum biomarker in spinocerebellar ataxia type 3
... Neurofilaments are the major elements of cytoskeletal proteins in neurons and are composed of three subunits called neurofilament light chain (NfL), medium chain and heavy chain [15]. NfL is detected in the ...
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Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers
... neurofilament light chain (NFL). Such data proposes that blood is a rich source of potential biomarkers reflecting central nervous system pathophysiology and should be fully explored for biomarkers that ...
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Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease
... Plasma neurofilament light chain (NFL) correlated with the kynurenine to tryptophan ratio (K/T) and other kynurenine pathway (KP) metabolites, namely kynurenine (KYN), kynurenic acid (KA[r] ...
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Genome-wide association study identifies two loci influencing plasma neurofilament light levels
... NFL: Neurofilament light; NFT: Neurofibrillary tangles; PET: Positron emission tomography; p-tau: Phosphorylated tau; t-tau: Total-tau; QC: Quality control; ROI: Regions of interest; SD: Standard ...
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Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
... Statistical analysis. Serum NfL concentrations were initially compared between the control group and the total FTD group. The Levene test for homogeneity demonstrated unequal variances between these 2 groups (Levene ...
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Blood neurofilament light chain as a biomarker of MS disease activity and treatment response
... Abbreviations: CI = confidence interval; Gd+ = gadolinium-enhancing; GeoMean = geometric mean; NfL = neurofilament light chain plasma level. All estimates are from a multiple linear regression of log(NfL) ...
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Monitoring disease activity in multiple sclerosis using serum neurofilament light protein
... 5 neurofilament light; OND 5 other neurologic disorder or symptom; ROC 5 receiver operating characteristic; RRMS 5 relapsing-remitting multiple sclerosis; Simoa 5 single-molecule ...
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Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia
... This study focused on two populations: 1. a clinical cohort of 34 FTD cases, 20 AD cases and 26 healthy controls and 2. a separate cohort of 10 post mortem verified FTD cases. We re-evaluated the clinical files of all ...
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Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer’s disease
... of neurofilament light (NfL) concentration using an ultrasensitive immunoassay on the Single molecule array (Simoa) platform has been demonstrated to be feasible and reliable, both in spor- adic Alzheimer ’ ...
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Serum neurofilament light in familial Alzheimer diseaseA marker of early neurodegeneration
... 5 neurofilament light; PSP 5 progressive supranuclear palsy; QC 5 quality control; RMT 5 Recognition Memory Test; Simoa 5 single molecule array; SOB 5 sum of boxes; TIV 5 total intracranial volume; WASI 5 ...
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Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer’s disease
... Background: A growing body of evidence suggests that the plasma concentration of the neurofilament light chain (NfL) might be considered a plasma biomarker for the screening of neurodegeneration in ...
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Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer’s disease
... Neurofilaments are found in the cytoplasm of neurons and act to transport nutrients and other molecules along axons. The subunit proteins constituting neurofilaments include neurofilament light (NfL), ...
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Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis
... To examine the mechanisms of autoimmunity to neu- rons we have developed a model of autoimmune induced axonal and neuronal damage following immunization of mice with the neuronal cytoskeletal protein neurofilament ...
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Neurofilament light chainA prognostic biomarker in amyotrophic lateral sclerosis
... NfL levels (median [interquartile range]) in patients with amyotrophic lateral sclerosis and controls in the cross-sectional analysis using (A) CSF, (B) serum, and (C) plasma (Mann–Whitney U test). Results of receiver ...
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A new enzyme-linked immunosorbent assay for neurofilament light in cerebrospinal fluid: analytical validation and clinical evaluation
... For the IDD group, we selected CSF samples from patients satisfying the following criteria at the time of CSF collection: 1) a diagnosis of clinically isolated syn- drome suggestive of M[r] ...
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NG2 cells response to axonal alteration in the spinal cord white matter in mice with genetic disruption of neurofilament light subunit expression
... green, before being dehydrated in graded ethanol, cleared in Histoclear, mounted with Vectashield mounting medium (Stem cell technology, USA) and then observed under a light microscope (Olympus BX51, Japan). For ...
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Neurofilament light and tau as blood biomarkers for sports-related concussion
... Axonal injury, particularly injury to white matter axons, has been hypothesized to be the key type of damage and the primary determinant of outcome following traumatic brain injury (TBI). 6 – 9 Neurofilament light ...
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Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome
... Chalfont, UK), then centrifuged in a swing-out rotor for 40 minutes at 400 × g without braking. Plasma samples were stored at − 80 °C. Plasma NF-L concentration was mea- sured by the same laboratory technician with ...
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