Neurogenic detrusor overactivity
Evaluation, treatment, and surveillance of neurogenic detrusor overactivity in spinal cord injury patients
... Neurogenic detrusor overactivity is a common urodynamic finding in patients with supra-sacral spinal cord ...of neurogenic detrusor overactivity with adequate bladder drainage, ...
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Impact of urinary incontinence on health-related quality of life, daily activities, and healthcare resource utilization in patients with neurogenic detrusor overactivity
... [4,5]. Neurogenic detrusor overactivity (NDO) is defined as bladder overactivity due to a relevant neurological condition, such as multiple sclerosis (MS), spinal cord injury (SCI), ...
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Protocol for a prospective magnetic resonance imaging study on supraspinal lower urinary tract control in healthy subjects and spinal cord injury patients undergoing intradetrusor onabotulinumtoxinA injections for treating neurogenic detrusor overactivity
... genic detrusor overactivity. Furthermore it will show whether neurogenic detrusor overactivity specific treat- ment such as intradetrusor onabotulinumtoxinA injec- tions induce ...
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Double anticholinergic therapy for refractory neurogenic and non neurogenic detrusor overactivity in children: Long term results of a prospective open label study
... In the present study, we found that the addition of a sec- ond, different anticholinergic is a successful approach in most children with refractory DO and NDO for improv- ing the continence status, surprisingly without ...
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<p>Real-World Effects of Mirabegron in Patients with Chronic Neurogenic Detrusor Overactivity – A Retrospective Cohort Study</p>
... Mirabegron, a selective β -3-adrenoceptor-agonist, is a potential treatment alternative for NDO. The activation of β -3-adrenoceptors causes relaxation of the detrusor smooth muscles 7 and thus, improves bladder ...
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Validation of a Dutch version of the Actionable 8-item screening questionnaire for neurogenic bladder overactivity in multiple sclerosis: an observational web-based study
... The 16-items Actionable Bladder Symptom Screening Tool (ABSST) was developed in response to the grow- ing need for an accurate way to identify MS patients with bladder problems [4]. This psychometrically vali- dated ...
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Health-related quality of life and economic impact of urinary incontinence due to detrusor overactivity associated with a neurologic condition: a systematic review
... idiopathic detrusor overactivity or idiopathic overactive ...with neurogenic detrusor overactivity (NDO) with urgency but without UI ...
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How to assess and predict success or failure of intra-detrusor injections with onabotulinumtoxinA
... Neurogenic detrusor overactivity is one of the most challenging problems in urology. Various disorders or in- juries affecting the central nervous system (e.g., stroke, Parkinson disease and multiple ...
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Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations
... [2]. Detrusor overac- tivity is often the underlying condition. Detrusor overac- tivity should be further qualified as neurogenic detrusor overactivity (NDO), when there is a relevant ...
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The use of urodynamic studies for the followup of neurogenic bladders treated with onabotulinumtoxinA
... Patients with neurologic disorders such as spinal cord injury, spina bifida and multiple sclerosis may suffer from neurogenic detrusor overactivity (NDO) or low bladder compliance. The majority of ...
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Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats
... and detrusor muscle in rats with BOO-associated DO, but no significant change in the expression of the CB2 receptor was ...the detrusor muscle during filling of the bladder by binding to CB1 and CB2 ...
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Enhanced expression of TWIK-related arachidonic acid-activated K+ channel in the spinal cord of detrusor overactivity rats after partial bladder outlet obstruction
... found to be up-regulated in the L6-S1 spinal cord of DO rats. Immunohistochemical staining showed increased ex- pression of the TRAAK channel in the dorsal horn and ventral horn of the spinal cord, which represent the ...
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Neurogenic overactive bladder in spinal cord injury and multiple sclerosis: role of onabotulinumtoxinA
... decreasing detrusor contractions in order to avoid elevated filling pressures is anticholinergic ...a neurogenic bowel, and exacerbation of their symptoms via anticholinergic side effects is often ...
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The angiotensin II receptors type 1 blockage affects the urinary bladder activity in hyperosmolar-induced detrusor overactivity in rats: Preliminary results
... Results. Intravesical hyperosmolar saline instillation induced DO. Telmisartan diminished the severity of hyperosmolar-induced DO. We observed a statistically significant increase of intercontraction interval (55%), ...
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Effect of detrusor overactivity on the expression of aquaporins and nitric oxide synthase in rat urinary bladder following bladder outlet obstruction
... The proportion of bladder smooth muscle was markedly increased in the BOO group compared with the control (Fig. 2). AQP2 was expressed throughout the cytoplasm of the epithelium and detrusor muscle layer, whereas ...
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Artificial urinary sphincter implantation: an important component of complex surgery for urinary tract reconstruction in patients with refractory urinary incontinence
... According to patients’ individual condition, the following operations were conducted before AUS placement, in- cluding two strictures incision, three sphincterotomies, and five urethral dilations in urethral injuries ...
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A Study of neurogenic bladder in children managed by both conservative line and surgery.
... treated neurogenic bladders (renal scarring, noncompliant fibrotic bladder) already have their origin in the first years of life, the frequency of multidisciplinary follow-up visits must be age dependent (3× ...
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Physical Inactivity: A Social Burden
... Type II urethral valves were initially described as folds radiating in a cranial direction from the verumontanum to the posterolateral aspect of the bladder neck. These folds are not obstructive but rather represent ...
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Cardiovascular consequences of KATP overactivity in Cantu syndrome
... ATP overactivity would be reduced action potential duration, shortening of the QT interval, and reduced contractility as a ...ATP overactivity results in the complex and diverse patho- physiology of CS is ...
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Primary intrathoracic malignant neurogenic tumor: report of three cases and comparison with benign neurogenic tumors resected at our institution
... Neurogenic tumor is a common intrathoracic neoplasm, representing approximately 20% of all adult and 35% of all pediatric mediastinal neoplasms [1]. Among these cases, malignant neurogenic tumor (MNT) of ...
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