neurokinin-1
Neurokinin 1 (NK 1) receptor is required in Clostridium difficile induced enteritis
... the neurokinin-1 receptor are protected from the secretory and inflammatory changes as well as from epithe- lial cell damage induced by toxin ...of neurokinin-1R deletion correlates with diminished ...
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Original Article MicroRNA-613 suppresses colon cancer proliferation via targeting neurokinin-1
... of neurokinin-1, we stably transduced miR-613-express- ing HCT8 cells with neuroki- nin-1 construct lacking the 3’-UTR regions and confirmed its ...that neurokinin-1 reversed at lea- st ...
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Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene
... The aim of this study was to test if genetic variation at the neurokinin 1 receptor gene ( TACR1 ) is associated with pain in individuals with radiographic knee OA.. Methods: Participa[r] ...
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Cellular and behavioral effects of lipopolysaccharide treatment are dependent upon neurokinin-1 receptor activation
... The neurokinin-1 receptor (NK1R) is the primary en- dogenous target of the neuropeptide substance P (SP). SP and the NK1R are widely expressed throughout the cen- tral nervous system (CNS) and, like NFkB, ...
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Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P
... Background: The tachykinin substance P (SP) is recognized to exacerbate inflammation at peripheral sites via its target receptor, neurokinin 1 receptor (NK-1R), expressed by leukocytes. More recently, ...
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In Silico Study of Neurokinin-1 Receptor Antagonists by QSAR Modeling Neerja Shukla
... QSAR studies were performed on a series neurokinin-1 receptor. neurokinin-1 receptor have been analyzed in relation to their physicochemical and molecular properties. On the basis of QSAR ...
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Treatment with Neurokinin-1 Receptor Antagonist Reduces Severity of Inflammatory Bowel Disease Induced by Cryptosporidium parvum
... major neurokinin receptors; substance P binds pref- erentially to the neurokinin-1 receptor (NK1-R), while neuro- kinin A (or substance K) and neurokinin B (or neuromedin K) preferentially ...
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Effects of Neurokinin 1 Receptor Inhibition on Anxiety Behavior in Neonatal Rats Selectively Bred for an Infantile Affective Trait
... Interest in understanding the etiology and developing new treatments for anxiety disorders in children and adolescents has led to recent studies of neurotransmitters not traditionally asso- ciated with neural pathways ...
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High expression of substance P and its receptor neurokinin-1 receptor in colorectal cancer is associated with tumor progression and prognosis
... the neurokinin-1 receptor (NK1R) to initiate tumor cell proliferation, angiogenesis, and migration, steps that are critical for tumor cell invasion and ...
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Controlling Chemotherapy Induced Nausea and Vomiting with Neurokinin 1 Receptor Antagonists in Patients on AC Based Chemotherapy—Are We There Yet?
... Chemotherapy-induced nausea and vomiting (CINV) are distressing side effects of chemotherapy. Neurokinin-1 recep- tor antagonists (NK1-RAs) have been incorporated in the contemporary management of CINV. ...
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Differential Expression of Neurokinin-1 Receptor by Human Mucosal and Peripheral Lymphoid Cells
... Substance P (SP) has been implicated in peripheral and mucosal neuroimmunoregulation. However, con- fusion remains regarding immunocyte expression of the receptor for SP, neurokinin-1 receptor (NK-1R), and ...
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Substance P and Antagonists of the Neurokinin-1 Receptor in Neuroinflammation Associated with Infectious and Neurodegenerative Diseases of the Central Nervous System
... receptor neurokinin-1 (NK1R) play in neuroinflammation associated with select bacterial, viral, parasitic, and neurodegenerative diseases of the central nervous ...
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Evolving role of neurokinin 1-receptor antagonists for chemotherapy-induced nausea and vomiting
... as neurokinin 1-receptor antagonists (NK 1 RAs), is underused in clinical ...NK 1 RAs are available, which have pharmacologic and clinical differences including formulation (intravenous vs ...
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Garnier, Agnès (2016): Neurokinin-1 receptor as a therapeutic target in hepatoblastoma. Dissertation, LMU München: Medizinische Fakultät
... Als Resultat fanden wir in den Hepatoblastoma-Fällen eine Überexpression des NK1R vor allem in der truncated Form. Aprepitant als NK1R Antagonist bewirkt sowohl eine signifikante Wachstumsinhibierung als auch ...
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The relationship of the neurokinin-1 receptor to reward and learning and memory behaviours in the mouse
... Mice with ablation o f N K l receptor-expressing neurones in the amygdala exhibited lower CPP scores than naive mice following conditioning with 3.0 mg.kg ' morphine[r] ...
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Bladder inflammatory transcriptome in response to tachykinins: Neurokinin 1 receptor-dependent genes and transcription regulatory elements
... hours) also presented a certain amount of shifted NKx-2.5 and NF-kappaB probes. An alternative explanation for these results is that mechanical isolation of the bladder mucosa caused the translocation of both ...
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Neurokinin-1 receptor is a novel positive regulator of Wnt/ β-catenin signaling in melanogenesis
... NK-1R, while L-733060 was used to inhibit it. The effects of NK-1R activation and inhibition on Wnt and its inhibitors were analyzed using western blot and real-time quantitative PCR. The results showed that SMSP ...
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Antagonist of the neurokinin-1 receptor curbs neuroinflammation in ex vivo and in vitro models of Lyme neuroborreliosis
... at 1:500, anti- human neuronal protein NeuN, MAB 377 clone A60, mouse IgG1 (Millipore) at 1:10, anti-human glial fibrillary acidic protein (GFAP), at 1:200, clone G-A-5 purified mouse immunoglobulin ...
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Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor
... Immunocytochemistry was performed as described pre- viously [30]. Mice were perfused transcardially with 50 mL of ice-cold PBS (10 mL/10 g body weight) followed by 4% paraformaldehyde (20 mL/10 g body weight). Brains ...
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Dual action of neurokinin-1 antagonists on Mas-related GPCRs
... over 1-minute intervals during 25-minute observation periods, and the investigator was not aware of the group allocation during scoring the study and behavioral ...
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