neuromuscular junction
Functional consequences of activity dependent synaptic enhancement at a crustacean neuromuscular junction
... several successive stimulation trains. Most obviously, the amplitude of the first EJP was enhanced by augmentation. This indicates that during ongoing gastric mill rhythms, augmentation leads to an already high amplitude ...
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Regulation of neuromuscular junction organization by Rab2 and its effector ICA69 in Drosophila
... The mechanisms underlying synaptic differentiation, which involves neuronal membrane and cytoskeletal remodeling, are not completely understood. We performed a targeted RNAi-mediated screen of Drosophila BAR-domain ...
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Differential localization of glutamate receptor subunits at the drosophila neuromuscular junction
... DGluRIII is a novel glutamate receptor at the Drosophila NMJ To define the molecular composition of the glutamate receptor complex at the Drosophila NMJ, we identified and characterized a novel muscle-expressed receptor ...
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Postsynaptic glutamate receptors regulate local BMP signaling at the Drosophila neuromuscular junction
... Drosophila neuromuscular junction (NMJ), a retrograde BMP signal functions to promote synapse growth, stability and homeostasis and coordinates the growth of synaptic ...
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Interaction between facilitation and presynaptic inhibition at the crayfish neuromuscular junction
... Presynaptic inhibition at the crayfish neuromuscular junction can cause relaxation of the muscle in the face of ongoing excitor axon activity. In this instance, relaxation is produced by the addition of ...
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Distal axon and neuromuscular junction degeneration in amyotrophic lateral sclerosis
... physical symptoms (12 weeks), however for nerve terminals and Schwann cells, significant differences were apparent as early as 8 weeks of age. Most previous research has focused on loss of the presynapse from the ...
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Identification of Mob2, a Novel Regulator of Larval Neuromuscular Junction Morphology, in Natural Populations of Drosophila melanogaster
... ABSTRACT Although evolutionary changes must take place in neural connectivity and synaptic architecture as nervous systems become more complex, we lack understanding of the general principles and speci fi c mechanisms by ...
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β Catenin gain of function in muscles impairs neuromuscular junction formation
... The neuromuscular junction (NMJ), a synapse between motoneurons and muscle fibers, is crucial for control of muscle contraction. This classic chemical synapse has served as an informative model of synapse ...
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Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction
... The BMP pathway is essential for scaling of the presynaptic motoneuron arbor to the postsynaptic muscle cell at the Drosophila neuromuscular junction (NMJ). Genetic analyses indicate that the muscle is the ...
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Regulation of WNT Signaling at the Neuromuscular Junction by the Immunoglobulin Superfamily Protein RIG-3 in Caenorhabditis elegans
... ABSTRACT Perturbations in synaptic function could affect the normal behavior of an animal, making it important to understand the regulatory mechanisms of synaptic signaling. Previous work has shown that in Caenorhabditis ...
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Aminergic and peptidergic modulation of motor function at an identified neuromuscular junction in Helisoma
... The objectives of this study were 1 to characterize through anatomical and electrophysiological techniques B19's neuromuscular junction NMJ, 2 to examine the modulatory actions of 5-HT, [r] ...
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Integrated genomics and proteomics of the Torpedo californica electric organ: concordance with the mammalian neuromuscular junction
... specific, neuromuscular junction (NMJ) specific, muscle specific or highly expressed in muscle, likely expressed in muscle based on function, expressed in neurons, or functions in metabolism and energy ...
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A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction
... skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate ...the neuromuscular junction are mediated by the synaptic portion of a basal lamina that completely ...
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Eps homology domain endosomal transport proteins differentially localize to the neuromuscular junction
... mammalian EHD1 might be an uncharacterized candidate neuromuscular junction protein. To investigate the expres- sion and localization profile of EHD1, the complete murine cDNA was cloned into M03 and M29 ...
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Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation
... mature neuromuscular junction ...selective neuromuscular pathology that was made worse by traumatic ...the neuromuscular system matures and reintroduced as needed to enhance SMN for remodeling ...
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Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways
... Understanding the developmental steps that shape formation of the neuromuscular junction (NMJ) connecting motoneurons to skeletal muscle fibers is crucial. Wnt morphogens are key players in the formation of ...
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A Genetic Screen for Suppressors of Drosophila NSF2 Neuromuscular Junction Overgrowth
... the neuromuscular junction of the pool of releasable synaptic vesicles, and increases within the intact larvae on a Nikon E600FN microscope using a synaptic fatigue (Stewart et ...
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Potential new therapeutic modality revealed through agent-based modeling of the neuromuscular junction and acetylcholinesterase inhibition
... mammalian neuromuscular junction (NMJ) based on an agent-based model (ABM) describing acetylcholine signal- ing through nicotinic receptors (Figure ...
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Claudin-19 Expression at the Neuromuscular Junction.
... adherens junction proteins, colocalizes with a TSC marker, suggesting the presence of adherens junctions and tight junctions in ...tight junction proteins, is known to be expressed by myelinating Schwann ...
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Development of an Amphibian Neuromuscular Junction in vivo and in Culture
... The studies on the normal development of the Xenopus myotomal neuromuscular junction that are considered below deal mainly with the temporal relationships between such events as the arri[r] ...
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