Neuromyelitis Optica
Effectiveness of rituximab in neuromyelitis optica: a meta-analysis
... Neuromyelitis optica (NMO) is a severe demyelinating disease that predominantly affects the optic nerve and spinal cord. The pathogenesis of NMO is related to aquaporin-4 autoantibody (AQP4-Ab) [1 – 3]. ...
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Neuromyelitis optica spectrum disorders without and with autoimmune diseases
... Neuromyelitis optica (NMO) is a severe demyelinating disease of the central nervous system that affects the optic nerve and spinal cord but has protean and diverse potential clinical and radiological ...
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The history of neuromyelitis optica
... As recently shown by us [10,15-17], Devic and Gault in their reviews overlooked some early cases of possible NMO, probably owing to the restricted bibliographic resources of the time (both Devic’s and Gault’s lists of ...
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Neuromyelitis Optica: A Diffusional Kurtosis Imaging Study
... RESULTS: Compared with healthy controls, several diffusional kurtosis imaging and DTI parameters were altered in various fiber tracts of patients with neuromyelitis optica (P ⬍ .05). A significant decrease (P ...
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Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica
... Eosinophils are abundant in inflammatory demyelinating lesions in neuromyelitis optica (NMO). We used cell culture, ex vivo spinal cord slices, and in vivo mouse models of NMO to investigate the role of ...
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A descriptive study of prevalence, clinical features and other findings of neuromyelitis optica and neuromyelitis optica spectrum disorder in Khuzestan Province, Iran
... Background: Neuromyelitis optica (NMO) is an uncommon neuro-inflammatory syndrome that has shown to be distinct from multiple sclerosis (MS) and associated with the autoantibody marker NMO- immunoglobulin G ...
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Challenges and opportunities in designing clinical trials for neuromyelitis optica
... Current management of neuromyelitis optica (NMO) is noncurative and only partially effective. Immunosuppressive or immunomodulatory agents are the mainstays of maintenance treatment. Safer, ...
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Association between neuromyelitis optica and tuberculosis in a Chinese population
... Neuromyelitis optica (NMO) is a severe demyelinating disease of the central nervous system (CNS) that prefe- rentially affects the optic nerve and spinal cord ...
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Autoantibodies against myelin antigens in patients with neuromyelitis optica
... Neuromyelitis optica (NMO) is an idiopathic and se- vere demyelinating, inflammatory disease that attacks the optic nerve and spinal cord. While this rare disorder re- sembles multiple sclerosis (MS) in ...
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Demyelinating syndrome in systemic sclerosis and neuromyelitis optica
... Background: This article reports a case diagnosis of a 44-year-old female who presented with intractable hiccups and vomit complicated with an acute onset of paraplegia. Transverse myelitis was evident on MRI and ...
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Clobetasol promotes remyelination in a mouse model of neuromyelitis optica
... Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system that can produce marked neurological deficit. Current NMO therapies include immunosuppressants, plasma ...
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Clinical Reasoning: Bacterial meningitis causing a neuromyelitis optica flare
... We posit that concurrent bacterial meningitis trig- gered the neuromyelitis optica (NMO) flare in our patient, as her pleocytosis and hypoglycorrhachia improved after broad-spectrum antibiotics (table 1). ...
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International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
... , and Chugai Phar- maceuticals. P. Waters is a named inventor on patents for antibody assays (no. 20120114666, application no. 1310855.0) and has received royalties. He has received a speaker honorarium from Biogen Idec ...
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MRI characteristics of neuromyelitis optica spectrum disorderAn international update
... Since its initial reports in the 19th century, neuromyelitis optica (NMO) had been thought to involve only the optic nerves and spinal cord. However, the discovery of highly specific anti– aquaporin-4 ...
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Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder
... NMOSD: Neuromyelitis optica spectrum disorder; OND: Other neurological disease; PBMC: Peripheral blood mononuclear cell; qPCR: Quantitative polymerase chain reaction; RRMS: Relapsing-remitting multiple ...
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International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
... Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies ...
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Neuromyelitis optica spectrum disorders with and without connective tissue disorders
... NMO: Neuromyelitis optica; NMOSD: Neuromyelitis optica spectrum disorders; NP: Neuropathic pain; OCB: Oligoclonal banding; ON: Optic neuritis; RA: Rheumatoid arthritis; RF: Rheumatoid factor; ...
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CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population
... Background: Neuromyelitis optica (NMO) is a serious inflammatory demyelinating disease (IDD), characterized by the inflammation and demyelination of optic nerves and spinal cords, which subsequently leads ...
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T cell-activation in neuromyelitis optica lesions plays a role in their formation
... Background: Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system (CNS), which is characterized by the presence of pathogenic serum autoantibodies against ...
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Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain
... Most neuromyelitis optica (NMO) patients have IgG against aquaporin-4 (AQP4), here termed AQP4-IgG [1,2]. AQP4 is a water channel protein found in astro- cytes throughout the central nervous system (CNS), ...
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