neuronal damage
<p>Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats</p>
... aggravated neuronal mitochondria damage 3 days after ...mitochondria damage in neurons via activating the PPAR δ /PGC-1 α ...reduces neuronal damage after hyperglyce- mic ICH by ...
12
Neuronal Alterations and Antioxidant Status of Lipopolysaccharide Induced Neuronal damage in Mice: Efficacy of Three Medicinal Plants
... 3A). Neuronal cells in LPS-induced when injected intraperitoneally with 250 µg/kg LPS, 4 hours before mice were sacrificed was characterized by retraction of cell bodies resulting in the formation of a clear space ...
7
Phospholipase A2 is involved in galactosylsphingosine induced astrocyte toxicity, neuronal damage and demyelination
... A recent study has identified a pathogenic phenotype of reactive astrocytes found in a number of neurodegenerative and neuroinflammatory disorders. These neurotoxic cells can directly induce neuronal and ...
19
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis
... juvenile neuronal ceroid lipofuscinosis the ultrastruc- tural visualization of storage material, in a distinctive pattern, called fingerprint profiles (FPPs) constitutes a disease ...
19
The Effect of PTZ - Induced Seizures on Neuronal Damage in Amygdala of Rats
... Dark neurons are seen in neurosurgical biopsies, experimental ischemia, hypoglycemia, and epilepsy. This study was aimed to investigate probable damage of amygdala due to pentylenetetrazol (PTZ) - induced acute ...
7
Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage
... glutamate-induced neuronal excitotoxicity, while accumulated evidence also demonstrated that GAPDH nuclear translocation plays a critical role in cell ...glutamate-mediated neuronal death and could serve as ...
12
Hemispheric language dominance studied with functional MR: preliminary study in healthy volunteers and patients with epilepsy
... early neuronal damage on language lateralization was studied by comparing the right-handed male volunteers with the right-handed male epilepsy patients with an early age at seizure onset (,5 years) and left ...
5
The discrediting of the monoamine hypothesis
... nificant fluctuations in transporter-dependent monoamine concentrations from day to day in the individual should lead to clinical states where the findings would wax and wane in a manner consistent with day-to-day ...
8
Full Text (PDF)
... documented patient with reversible parkinsonism due to deep ve- nous system (incidentally, the title wrongly reports cortical venous thrombosis). MR diffusion-weighted images (DWI) demon- strated reversible ...
5
The treatment of status epilepticus: Experimental and clinical aspects
... l neuronal damage induced by kainic acid seizures, but did not significantly reduce the seizures (Lason et ...seizure-related damage in several brain regions without suppressing seizure activity in ...
209
Excitatory Amino Acids Contribute to the Pathogenesis of Perinatal Hypoxic Ischemic Brain Injury
... observations that intra-cerebral injection of the competitive EAA antagonist arninophosphonoheptanoic acid AP7 attenuated acute ischemic neuronal damage 3 and that preceding deafferentat[r] ...
9
Full Text (PDF)
... documented patient with reversible parkinsonism due to deep ve- nous system (incidentally, the title wrongly reports cortical venous thrombosis). MR diffusion-weighted images (DWI) demon- strated reversible ...
5
Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects
... of neuronal damage evident in the pons and cerebellum, we further analyzed the effects of LPS on myelination in these two brain regions at days LPS1, LPS3, LPS5, LPS7, and LPS9 (representative images in ...
18
Muscle and not neuronal biomarkers correlate with severity in spinal and bulbar muscular atrophy
... muscle damage and mass were altered, the latter showing correlation with clinical measures of disease, sug- gesting that biomarkers of muscle damage and mass, rather than neuronal damage, ...
12
Novel Roles of Cell Cycle Regulator E2f1 in the Cns: Implications for Synaptic Damage in HIV-Associated Neurocognitive Disorders
... of neuronal damage, neurons themselves are not susceptible to HIV infection as they lack CD4 receptors necessary for viral entry (Gonzalez-Scarano & Martin-Garcia 2005, Dalgleish et ...the ...
218
Uncoupling oxidative/energy metabolism with low sub chronic doses of 3-nitropropionic acid or iodoacetate in vivo produces striatal cell damage
... cellular damage like that earlier reported [3, 31]. Neuronal damage pro- duced by intraperitoneal administration of 3-NP in low doses, has been described at the onset of the neurodegenerative process ...
14
Hypothalamic Obesity following Craniopharyngioma Surgery: Results of a Pilot Trial of Combined Diazoxide and Metformin Therapy
... (i) damage to hypothalamic nuclei and neuronal circuits involved in appetite and body weight regulation and (ii) a primary defect of insulin hypersecretion due to hypotha- lamic damage-induced vagal ...
7
<p>The Role of the Reactive Oxygen Species Scavenger Agent, Astaxanthin, in the Protection of Cisplatin-Treated Patients Against Hearing Loss</p>
... These positive effects have been attributed to the ability of astaxanthin to scavenge free radicals, quench singlet oxygen, and inhibit lipid peroxidation. The effect of astaxanthin on protecting cellular membranes ...
13
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.
... Oxidative damage to nucleic acids is evident in mild cognitive impairment (MCI) and early Alzheimer’s disease (AD) [2–4], suggesting that oxidative stress is an early contribu- tor to neuronal dysfunction, ...
14
Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability
... The extent of cell damage from exposure to high concen- trations (50, 100, and 200 µ M) of fullerenol was assessed. Neurobasal medium (control) or fullerenol was added to the cells which have been cultured for 7 ...
11