Neuronal Degeneration
Neuronal degeneration and mitochondrial dysfunction
... selective neuronal degeneration (Figure 1 and Table ...acute degeneration of the optic nerve causing bilateral visual failure and ...ganglia degeneration and dystonia, and with a maternally ...
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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
... promoting neuronal survival, differentiation, and synaptic ...prevented neuronal degeneration with efficacy equal to that of BDNF, and when administered in vivo, it caused hippocampal and striatal ...
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Etifoxine improves sensorimotor deficits and reduces glial activation, neuronal degeneration, and neuroinflammation in a rat model of traumatic brain injury
... EFX treatment after TBI considerably improves func- tional outcomes. This effect is associated with reductions in neuronal degeneration, in glial scar formation and in microglial activation. ...
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Hypothesis on Remote Memory Forming from Heterosynaptic LTD Mediated Neuronal Degeneration
... LTD-mediated neuronal degeneration supplements a new form of neuronal plasticity for memory in addition to the contemporary LTP and ...LTD-mediated neuronal degeneration would last long ...
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Neuronal degeneration in autonomic nervous system of Dystonia musculorum mice
... the neuronal number of ciliary ganglion was significantly decreased in dt/dt ...the neuronal death during cell ...but neuronal degeneration is limited to peripheral neurons derived from neural ...
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Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis
... axonal degeneration in MS is highly complex and involves several neurological and immunological ...of neuronal degeneration and inflammation in EAE [51], suggesting that it plays a corresponding role ...
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Anchored FRET sensors detect local caspase activation prior to neuronal degeneration
... To investigate early degenerative events in neurites and cell bodies we have developed the first model sys- tem for spatiotemporal monitoring of caspase activation in neuronal cells. Caspase-3, -6, and -9 have ...
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Vascular endothelial growth factor A165b prevents diabetic neuropathic pain and sensory neuronal degeneration
... TRPA1 channel activation was assayed in immortalized embryonic rat sensory neurons, 50B11, in line with the requirements of UK legislation and the 3Rs. 50B11 cells were maintained under previously published conditions ...
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Absence of IFNγ expression induces neuronal degeneration in the spinal cord of adult mice
... Interferon gamma expression within the nervous sys- tem is classically associated with an inflammatory response after injury [11]. In this way, it is normally involved as a part of the physiological response to tissue ...
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5,6,7,4’-Tetramethoxyflavanone protects against neuronal degeneration induced by dexamethasone by attenuating amyloidogenesis in mice
... phorylated neuronal cytoskeleton protein (tau protein), which aggregates into a neurofibril- lary tangle ...impairs neuronal synaptic function by decreasing the expression of both presyn- aptic molecules, ...
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Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice
... to degeneration of DA neurons and clinical manifes- tations of ...as degeneration of nigrostriatal DA neurons in the SN or noradrenergic neu- rons in the ...
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Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson’s disease (PD)
... Impairment of UPS in PD pathogenesis was estab- lished with mutations of Parkin, a HECT/RING hybrid ubiquitin E3 ligase [27, 28], and other genetic forms of PD [20, 29]. The impairment of UPS functions is also implicated ...
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5,6,7,4’-Tetramethoxyflavanone protects against neuronal degeneration induced by dexamethasone by attenuating amyloidogenesis in mice
... 3 Department of Chemistry, School of Science, University of Phayao, Phayao, Thailand 4 Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200,. Thailand[r] ...
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Pathological changes leading to neuronal degeneration in Alzheimer's disease
... Overall, AD brains contain a higher relative proportion of fibrillar and dense-core AP plaques than preclinical AD cases, and it is these AP plaque types that are more regularly associat[r] ...
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ALTERED SERUM MARKER OF THYROID PROFILE AND ANTIOXIDANT ENZYMES IN INDIVIDUALS ALZHEIMER'S DISEASE
... Thyroid dysfunction and oxidative stress are incriminated to play a central role in the pathological processes that lead to neuronal degeneration in patients with Alzheimer’s disease[r] ...
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Galectin-1 expression in innervated and denervated skeletal muscle
... in neuronal degeneration/regeneration, we examined the expression of Gal1 mRNA and Gal1-like immunoreactivity in innervated and denervated mouse and rat skeletal muscle, showing that, following denervation, ...
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The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration
... prevents neuronal degeneration ...dopaminergic neuronal loss in the substantia nigra (SNpc) when injected intra-nigrally ...dopaminergic degeneration, albeit not to the same ...
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Original Article SWI evaluation of mesenchymal stem cells labelled with SPIO-PLL in the treatment of hypoxic-ischemic brain damage in neonate rats
... [26]. Degeneration and necrosis of some neurons and slight edema of the brain tissues indicate net amelioration of HIBD over time (Figure 4), which conforms with the decrease of SWI phase values from ...minor ...
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Volumetric Description of Brain Atrophy in Neuronal Ceroid Lipofuscinosis 2: Supratentorial Gray Matter Shows Uniform Disease Progression
... The finding that GM regions showed a more uniform decline compared with WM regions is also in keeping with histopathologic findings of the underlying neuronal degeneration in CLN2 diseas[r] ...
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NEUROINFLAMMATION IN ALZHEIMER’S DISEASE AND INVOLVEMENT OF INTERLEUKIN-1: A MECHANISTIC VIEW
... Ageing is a universal biological fact and a natural process. It begins from the day we are born, or perhaps even before. Of the world’s 580 million elderly, 77 million (22% of total) live in India. The increasing life ...
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