• No results found

neuronal excitability

ROLES OF THE ION CHANNEL NALCN IN NEURONAL EXCITABILITY CONTROL

ROLES OF THE ION CHANNEL NALCN IN NEURONAL EXCITABILITY CONTROL

... basal neuronal activities by providing the Na + leak conductance, even if NALCN were not directly linked to epilepsy, it may still be a target for epilepsy treatment by reducing basal neuronal ...

211

Rinke, Ilka
  

(2010):


	Chloride regulatory mechanisms and their influence on neuronal excitability.


Dissertation, LMU München: Fakultät für Biologie

Rinke, Ilka (2010): Chloride regulatory mechanisms and their influence on neuronal excitability. Dissertation, LMU München: Fakultät für Biologie

... Background (or leak) conductances are important in determining membrane resting potential and input resistance, both key components of neuronal excitability. Some of the leak conduc- tance is mediated by ...

154

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

... their resting membrane potentials are comparable, neu- rons from the constitutive P2Y12R KO mice had a lower threshold for action potential firing compared with WT groups (n = 8 neurons from 3 mice for each group, p < ...

10

Postsynaptic protein kinase a reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS

Postsynaptic protein kinase a reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS

... match neuronal excitability in response to fluc- tuating synaptic excitation is clearly advantageous when activity levels are changing rapidly, for example during embryonic neu- ronal circuit formation ...

10

Mutations in the Drosophila pushover Gene Confer Increased Neuronal Excitability and Spontaneous Synaptic Vesicle Fusion

Mutations in the Drosophila pushover Gene Confer Increased Neuronal Excitability and Spontaneous Synaptic Vesicle Fusion

... Interactions of push with quinidine: The effects of many mutations that affect synaptic transmission as a result of an increase in neuronal excitability are en- hanc[r] ...

9

Sodium channel NaV1 9 mutations associated with insensitivity to pain dampen neuronal excitability

Sodium channel NaV1 9 mutations associated with insensitivity to pain dampen neuronal excitability

... revealed a clear relationship of channel dysfunction with the associated and contrasting clinical phenotypes. Here, we have elucidated the functional consequences of a Na V 1.9 mutation (L1302F) that is associated with ...

11

Role of the inward rectifying potassium channel, Kir4.1,  in astrocyte physiology and neuronal excitability

Role of the inward rectifying potassium channel, Kir4.1, in astrocyte physiology and neuronal excitability

... When one considers the abundance and complexity of reported neuron-glia interactions, it becomes evident that CNS functioning and therefore functioning of the organism as a whole depends on the multidirectional ...

233

The Drosophila inebriated-Encoded Neurotransmitter/Osmolyte Transporter: Dual Roles in the Control of Neuronal Excitability and the Osmotic Stress Response

The Drosophila inebriated-Encoded Neurotransmitter/Osmolyte Transporter: Dual Roles in the Control of Neuronal Excitability and the Osmotic Stress Response

... of neuronal mutant for either Shaker (Sh) or ether a go-go (eag), which excitability and the osmotic stress response: The osmotic each encode distinct potassium channel ␣-subunits, or stress-sensitive and ...

9

Acute lipopolysaccharide exposure facilitates epileptiform activity via enhanced excitatory synaptic transmission and neuronal excitability in vitro

Acute lipopolysaccharide exposure facilitates epileptiform activity via enhanced excitatory synaptic transmission and neuronal excitability in vitro

... on neuronal circuits is not well ...the excitability of neuronal circuits in acute hippocampal ...the excitability of CA1 pyramidal neurons, as demonstrated by a decrease in rheobase and an ...

7

Protein kinase C activation mediates interferon-β-induced neuronal excitability changes in neocortical pyramidal neurons

Protein kinase C activation mediates interferon-β-induced neuronal excitability changes in neocortical pyramidal neurons

... several neuronal ion chan- nels, profoundly increasing neuronal ...by neuronal activity itself, for instance by high frequency stimulation in rat hippocampus ...

14

TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation

TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation

... We performed immunofluorescence staining to explore the distribution and subcellular location of TMEM25. We subse- quently assessed changes in the electrophysiology of CA1 pyra- midal neurons in mice following ...

14

A novel role for lymphotactin (XCL1) signaling in the nervous system: XCL1 acts via its receptor XCR1 to increase trigeminal neuronal excitability

A novel role for lymphotactin (XCL1) signaling in the nervous system: XCL1 acts via its receptor XCR1 to increase trigeminal neuronal excitability

... subthreshold neuronal activity of this type has been char- acterized in the spinal dorsal horn (Chapman et ...hyperactive neuronal discharges are an estab- lished characteristic of chronic pain and a known ...

17

Corticotropin releasing factor receptors couple to multiple g proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning

Corticotropin releasing factor receptors couple to multiple g proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning

... hippocampal neuronal excitability and hippocampus-dependent learning in two mouse inbred strains, BALB/c and C57BL/ ...the neuronal activity in both mouse inbred ...

9

The Drosophila melanogaster Translational Repressor Pumilio Regulates Neuronal Excitability

The Drosophila melanogaster Translational Repressor Pumilio Regulates Neuronal Excitability

... rons elicit an ejp following 85% of the stimuli (Figure 7C). Flies overexpressing pum in their nervous system were also tested for behavioral defects and temperature- sensitive paralysis but no differences from wild type ...

10

A Co-operative Regulation of Neuronal Excitability by UNC-7 Innexin and NCA/NALCN Leak Channel

A Co-operative Regulation of Neuronal Excitability by UNC-7 Innexin and NCA/NALCN Leak Channel

... unc-7 was reported to be genetically epistatic to unc-79 and unc-80 for volatile anesthetic response [48,49]. While unc-79 and unc-80 loss of function mutants are hyper- sensitive to halothane and chloroform, the loss of ...

16

Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway

Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway

... onal excitability, including resting membrane potential, were not significantly changed by 100 nM CCK-8 (not ...CCK-BR-induced neuronal hyperexcit- ability through I A decrease, 4-AP was applied prior ...

15

&alpha;-lipoic acid suppresses neuronal excitability and attenuates colonic hypersensitivity to colorectal distention in diabetic rats

&alpha;-lipoic acid suppresses neuronal excitability and attenuates colonic hypersensitivity to colorectal distention in diabetic rats

... hypersensitivity, it is reasonable to hypothesize that ALA treatment attenuated the colonic visceral hypersensitivity through suppressing NaV1.7 and NaV1.8 expressions and sodium current density in colon DRG neurons of ...

11

Regulation of neuronal excitability through pumilio dependent control of a sodium channel gene

Regulation of neuronal excitability through pumilio dependent control of a sodium channel gene

... Central neurons must face and adapt to changing patterns of synaptic drive. These adaptations are essential to prevent neurons from either falling silent as synaptic excitation falls or, conversely, becoming saturated ...

10

Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia

Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia

... Cerebellar ataxia, a devastating neurological disease, may be initiated by hyperexcitability of deep cerebellar nuclei (DCN) secondary to loss of inhibitory input from Purkinje neurons that frequently degenerate in this ...

10

Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice

Effects of acute and chronic administration of neurosteroid dehydroepiandrosterone sulfate on neuronal excitability in mice

... Moreover, following chronic DHEAS (10 mg/kg) treat- ment, we observed no significant differences compared to control group in the doses of pentylentetrazole (Figure 3A and B), picrotox[r] ...

15

Show all 1607 documents...

Related subjects