neuronal injury
Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition
... diagnostic criteria [8]. These advances have led to the proposal of a hypothetical AD model [9] for the patho- logical and biomarker changes to emerge over one or more decades before the onset of dementia or mild cog- ...
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Microglia and astroglia: the role of neuroinflammation in lead toxicity and neuronal injury in the brain
... Microglial cells are a predominant source of various inflammatory cytokines, that is, interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-a), and interferon-gamma (IFN-γ), which can then induce a broad spectrum ...
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The impact of neuronal Notch-1/JNK pathway on intracerebral hemorrhage-induced neuronal injury of rat model
... Figure 5: Notch-1 induces JNK signals to meditate neuronal injury. Cells were pretreated with thrombin (40U/ml), and then DAPT was added 24 h before. At the same time, cells were also transfected with ...
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Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury
... of neuronal in- jury/death, bears significant ...between neuronal injury and hα-syn ...when neuronal integrity is ...(i) neuronal activity in the form, for ex- ample, of synaptic ...
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The role of extracellular metallothioneins in the cellular response to neuronal injury
... 5.4.1 MT-IA promotes wound healing and reactive axonal growth following cortical brain injury 54 5.4.2 Release of endogenous MT-I/-II in response to neuronal injury 56 5.4.3 The possible[r] ...
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Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci
... of neuronal receptors and excitotoxic cell death (40, ...mediating neuronal injury in bacterial meningitis (13, ...excitotoxic neuronal injury is tightly linked to the generation of ...
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Original Article Eupatilin inhibits OGD/R-induced neuronal injury in PC12 cells
... induced neuronal injury in differentiated PC12 ...OGD/R-induced neuronal injury, with evidence of increased cell viability and decreased LDH ...OGD/R-induced neuronal injury in ...
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Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection
... Expression of chemoattractants Ccl5 and Ccl8, which pro- mote monocyte and lymphocyte recruitment [106,107], is consistent with the presence of B cells and the dominance of immunoglobulin genes and the perivascular and ...
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Neuronal injury: folate to the rescue?
... cord injury, the SAM/SAH ratio (see above) had declined by approximately ...transection injury revealed reduced enzy- matic activity, whereas MS protein levels observed on Western blots did not ...cord ...
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The inflammatory response and neuronal injury in Streptococcus suis meningitis
... In the present study, we observed a tendency towards increased proliferation and neuronal differentiation dur- ing S. suis CNS infection as signs of regeneration. In humans, significant proliferation of progenitor ...
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Original Article Hydrogen sulfide protects focal cerebral ischemia-reperfusion injury in rats through the PI3K/Akt signaling pathway
... Previous studies showed that sulphuretted hydrogen can inhibit the inflammatory reaction and resist apoptosis to protect against whole- brain I/R damage by preventing oxidative stress [14]. In the cultured hippocampal ...
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Evidence From Proton Magnetic Resonance Spectroscopy for a Metabolic Cascade of Neuronal Damage in Shaken Baby Syndrome
... of neuronal marker NAA occurs (t 1/2 ; 2 days) in the only infant from whom accurate data are available (B), and from the earliest data point available in infant C, suggests an accelerated process triggered by an ...
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Neuronal and glial changes in the brain resulting from explosive blast in an experimental model
... brain injury (mTBI) is the signature injury in warfighters exposed to explosive ...tertiary injury from blasts. We found small but significant levels of neuronal loss in the hippocampus, a ...
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Neuroprotective effects of atorvastatin through anti oxidant, anti inflammatory and anti apoptotic mechanisms against transient ischemic/reperfusion injury in diabetic rats
... In conclusion, the current study provides the first preclinical data that demonstrates the robust neuroprotective potential of atorvastatin against neuronal injury in diabetic rats submi[r] ...
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Reduced GABAergic neuronal activity in zona incerta causes neuropathic pain in a rat sciatic nerve chronic constriction injury model
... nerve injury on ZI neuronal output, the study recorded neuronal activity in the ZI of CCI (n = 6) and sham-treated (n = 6) ...on neuronal activity, sham-treated and CCI rats treated with ...
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Spinal cord injury induces astroglial conversion towards neuronal lineage
... More recent findings suggest that enforced expression of neurogenic factors including Notch [21], Sox2 [22], NeuroD1 [23], Shh [24], Ascl1, Brn2 and Myt1l [25] can directly convert astrocytes into functional neurons in ...
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Association of impaired neuronal migration with cognitive deficits in extremely preterm infants
... defective neuronal alignment is presumed to be another mechanism underlying the later development of cognitive impairment in the extremely preterm ...infants. Neuronal migration and alignment may also be ...
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Clinical significance of metallothioneins in cell therapy and nanomedicine
... also altered. The cytokines that were upregulated included interleukin-1 α (IL-1 α ), IL-1 β , IL-6, the small inducible cytokine, interferon protein 10P-10, CXC chemokine LIX, and insulin-like growth factor-binding ...
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The response of the mature central nervous system to traumatic brain injury
... The inability of mature axons to regenerate may also be due in part to the absence of growth permissive signals or the presence of growth inhibitory cues at the site of injury. The current chapter investigated the ...
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Cerebral Proton Magnetic Resonance Spectroscopy in Children with Diabetic Ketoacidosis
... MATERIALS AND METHODS: Twenty-nine children with DKA underwent cerebral proton MR spectros- copy during DKA treatment (2–12 hours after initiating therapy) and after recovery from the episode (72 hours or more after the ...
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