neutral endopeptidase
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury
... Neutral endopeptidase (NEP; EC 3.4.15.1), also known as enkephalinase, neprilysin, common acute lymphoblastic leukemia antigen (CALLA) or CD10, is a membrane- bound zinc-metallopeptidase enzyme that ...
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CD10/neutral endopeptidase 24 11 in developing human fetal lung Patterns of expression and modulation of peptide mediated proliferation
... The cell membrane-associated enzyme CD10/neutral endopeptidase 24.11 (CD10/NEP) functions in multiple organ systems to downregulate responses to peptide hormones. Recently, CD10/NEP was found to hydrolyze ...
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Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs
... Abstract To determine whether recombinant enkephalinase neutral endopeptidase, EC 3.4.24.11 prevents cough induced by exogenously applied and endogenously released neuropeptides, we meas[r] ...
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Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase
... Substance P and related tachykinins contribute to the airway hyperresponsiveness caused by toluene diisocyanate (TDI) in guinea pigs. Neutral endopeptidase (NEP) is an important modulator of substance ...
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Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling
... Neutral endopeptidase 24.11 (NEP, CD10) is a cell-surface enzyme expressed by prostatic epithe- lial cells that cleaves and inactivates neuropeptides implicated in the growth of androgen-inde- pendent ...
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Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure
... The renal natriuretic actions of endogenous atrial natriuretic factor are enhanced by neutral endopeptidase inhibition (NEP-I). Recognizing that activation of the renin-angiotensin- aldosterone system in ...
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Neutral endopeptidase like enzyme controls the contractile activity of substance P in guinea pig lung
... phosphoramidon. The increase in tissue responsiveness by these inhibitors was relatively specific for substance P among several other spasmogenic peptides, including formyl- methionyl-leucyl-phenylalanine and the ...
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Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure
... the liver cell damage seen in acute liver failure is not only due to direct effects of the precipitating drug, toxin, viral or other cause, but also due to a secondary release of proinflammatory and cytotoxic mediators ...
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Common acute lymphoblastic leukemia antigen expressed on leukemia and melanoma cell lines has neutral endopeptidase activity
... lymphoblastic leukemia antigen (CALLA, CD10) translated from a normal human kidney cDNA clone is identical to that of neutral endopeptidase (NEP, EC 3.4.24.11). In this study, we show that by flow ...
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Neutral endopeptidase 24 11 in neutrophils modulates protective effects of natriuretic peptides against neutrophils induced endothelial cytotoxity
... This study was performed to determine effects of atrial and brain natriuretic peptides (ANP, BNP) on neutrophils- induced endothelial injury which is known to play a role in the pathophysiology of ischemia/reperfusion ...
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Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig Possible role of free radicals
... endopeptidase (NEP). After exposure to air or to cigarette smoke we measured the change in total pulmonary resistance (RL) induced by increasing concentrations of aerosolized substance P in the absence or presence ...
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Prognostic significance of the combined expression of neutral endopeptidase and dipeptidyl peptidase IV in intrahepatic cholangiocarcinoma patients after surgery resection
... In conclusion, our data from the current study suggest for the first time that both the expression of NEP and DPP IV proteins may be upregulated in human IHCC tissues, and the combine[r] ...
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CD10/neutral endopeptidase 24 11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin like peptides
... Abstract Bombesin-like peptides BLPs are mitogens for bronchial epithelial cells and small cell lung carcinomas, and increase fetal lung growth and maturation in utero and in organ cultu[r] ...
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Neutral endopeptidase inhibitors potentiate substance P and capsaicin induced cough in awake guinea pigs
... investigator did not know whether substance P or diluent alone was aerosolized, substance P (10(-16) M) caused cough. Leucine-thiorphan (10(-5) M) and phosphoramidon (10(-5) M) potentiated substance P-induced cough; NEP ...
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Neutral endopeptidase and kininase II mediate glucocorticoid inhibition of neurogenic inflammation in the rat trachea
... Because of the technical difficulty ofassessing enzymatic activity in the postcapillary venule in vivo, in this study we examined the effect of a selective inhibitor of NEP, phosphoramid[r] ...
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Peptidase modulation of the pulmonary effects of tachykinins in tracheal superfused guinea pig lungs
... The effects of the angiotensin converting enzyme ACE inhibitor captopril and the neutral endopeptidase NEP inhibitors thiorphan and SCH 32615 on the changes in airway opening pressure Pa[r] ...
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A propeptide toolbox for secretion optimization of Flavobacterium meningosepticum endopeptidase in Lactococcus lactis
... Results: To expand the propeptide library for secretion optimization, we have mined and characterized three natu‑ rally occurring propeptides from the sequenced genomes of 109 Lactococcus species. These newly‑mined ...
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Characterization of a Serine Proteinase Mediating Encystation of Acanthamoeba
... serine-type endopeptidase, peptidase M28, an aspartyl aminopeptidase-like protein, and a subtilisin-like serine ...serine-type endopeptidase, pepti- dase M28, and the aspartyl aminopeptidase-like protein ...
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Atypical emotional anticipation in high-functioning autism
... a neutral expression, a 10 % joy or a 10 % anger expression [32], were presented to the HFA and TD groups to assess any differ- ences in their perceptual report of the facial expression dis- played in the final ...
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Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
... asparagine endopeptidase (AEP) or other lysosomal cysteine proteases, or by increased endocytic substrate load, is not dependent on the transcription factor EB (TFEB) but rather is triggered by STAT3 activation ...
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