Neutrophil degranulation
Vaccines for counteracting inhibition of neutrophil degranulation
... Vaccines for counteracting inhibition of neutrophil degranulation by pathogenic cellular microorganisms comprise one or more purines conjugated to antigenic carriers. The purines include adenine and/or ...
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Patients with allergic rhinitis and allergic asthma share the same pattern of eosinophil and neutrophil degranulation after allergen challenge
... The link between the upper and lower airways is well- established [21]. Many studies have reported both blood eosinophilia and local eosinophilia in nasal lavage as well as in induced sputum both during pollen season and ...
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Hypoxia upregulates neutrophil degranulation and potential for tissue injury
... hypoxia-augmented degranulation, these data suggest a HIF-independent ...on degranulation under normoxic and hypoxic ...that neutrophil degranulation is a calcium-dependent ...reduced ...
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Citrate confers less filter-induced complement activation and neutrophil degranulation than heparin when used for anticoagulation during continuous venovenous haemofiltration in critically ill patients
... nuclear neutrophil degranulation products such as elastase and MPO when blood comes into contact with the extra- corporeal system and the haemofilter, during CVVH in critically ill patients with ...
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Fibronectin degradation products containing the cytoadhesive tetrapeptide stimulate human neutrophil degranulation
... We investigated whether adhesive glycoproteins, such as fibronectin or fibrinogen, could function to provide a nidus for neutrophil degranulation. Elastase release in recalcified plasma was normal in ...
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Defective Neutrophil Degranulation Induced by Interleukin-8 and Complement 5a and Down-Regulation of Associated Receptors in Children Vertically Infected with Human Immunodeficiency Virus Type 1
... PMN degranulation responses and the expression of specific receptors that mediate these responses in a group of children vertically infected with ...PMN degranulation in response to interleukin-8 (IL-8) and ...
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Regulation of apoptosis and priming of neutrophil oxidative burst by diisopropyl fluorophosphate
... We measured neutrophil degranulation by measuring peroxidase release as described [22]. We plated 1.5 × 10 5 neutrophils in triplicate in a 96 well tissue culture plate (Sarstedt Microtest Plate). We added ...
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The elevation in circulating anti-angiogenic factors is independent of markers of neutrophil activation in preeclampsia
... [21]. Neutrophil counts are increased in nor- mal pregnancy, and further elevated in preeclampsia ...Mild neutrophil activation in the maternal circulation occurs in response to circulating ...
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Alkalinizing the intralysosomal pH inhibits degranulation of human neutrophils
... inhibited neutrophil degranulation in response to the calcium ionophore A23187, phorbol myristate acetate, or the chemotactic peptide, formyl-methionine-leucine-phenylalanine plus cytochalasin ...
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Abrogation of Antibody-Induced Arthritis in Mice by a Self-Activating Viridin Prodrug and Association with Impaired Neutrophil and Endothelial Cell Function
... group. Neutrophil degranulation was investigated by measuring the absorbance (at 405 nm) of a colorimetric elastase substrate (methoxysuccinyl-alanine-alanine-proline- ...a neutrophil suspension (5 × ...
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Faecal calprotectin level for assessing endoscopic activity and predicting future clinical course in patients with moderately active ulcerative colitis undergoing granulomonocytapheresis: a prospective cohort study
... Calprotectin is a calcium-binding protein, a member of the S100 family, abundant in the cytoplasm of neutro- phils [17, 18]. During active IBD, neutrophils infiltrate the intestinal mucosa and an increase in faecal ...
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Mechanisms of Degranulation in Neutrophils
... modulate neutrophil degran- ulation. Neutrophil degranulation is an important event in inflammatory diseases such as asthma and chronic obstructive pulmonary disease ...of neutrophil ...
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NEUTROPHIL CHEMOTACTIC DEFECT IN 60 PATIENTS WITH RICKETS
... There arc a number of proteins such as actin and myosin that form filamentous and microtubulous struc tures in leukocytes. These proteins are structurally and enzymatically similar (0 the actin-myosin system in ...
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Neurotensin is a proinflammatory neuropeptide in colonic inflammation
... 1). Neutrophil infiltration, congestion and edema, and epithelial cell damage correlated temporally with changes in permeability and fluid secretion (Table ...
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Influence of dexamethasone treatment on bovine neutrophil arachidonic acid metabolism and response to tuftsin
... It was concluded that in vivo dexamethasone treatment results in the suppression of bovine neutrophil arachidonic acid metabolism which could account for the changes in neutrophil iodina[r] ...
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Neutrophil accumulation in the lung in alpha 1 antitrypsin deficiency Spontaneous release of leukotriene B4 by alveolar macrophages
... for neutrophil elastase, we hypothesized that the neutrophil accumulation in the lower respiratory tract in alpha 1AT deficiency may result, in part, from release of neutrophil chemotactic activity ...
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Characterisation of a kinase involved in the phosphorylation of the p47phox component of the neutrophil NADPH oxidase
... Since neither p38 MAPKnor ERK were responsible for the phosphorylation of p47^*'''', recombinant p47^*‘’^ was used as substrate to detect other potential p47^*‘''' kinases. Activity was detected on the membranes of ...
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Neutrophil endothelial cell interactions Modulation of neutrophil adhesiveness induced by complement fragments C5a and C5a des arg and formyl methionyl leucyl phenylalanine in vitro
... stimulating neutrophil chemotaxis and enzyme release. Nonstimulated neutrophils adhered preferentially to human endothelial cells compared with fibroblasts or smooth muscle cells, suggesting that endothelial cells ...
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Phase I study of granulocyte colony stimulating factor in patients with transitional cell carcinoma of the urothelium
... phosphatase, a marker of secondary granule formation. In six of eight patients analyzed, an increase in bone marrow myeloid to erythroid cell ratio was seen. Day 14 peripheral blood cell derived colony forming unit ...
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Anti Neutrophil Cytoplasmic Antibodies Stimulate Release of Neutrophil Microparticles
... We next investigated the ability of NMPs to cause endothelial activation after binding. HUVEC activation in the presence of NMPs was measured by endothelial surface expression of ICAM-1 and E-selectin using fl ow ...
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