neutrophil elastase
Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses
... for neutrophil elastase [25], and is expressed on a var- iety of cells including airway epithelial cells, fibro- blasts, myocytes, sensory neurons, and bronchial and vascular smooth muscle ...
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A critical role for neutrophil elastase in experimental bullous pemphigoid
... Bullous pemphigoid (BP) is an autoimmune skin disease characterized by subepidermal blisters and autoantibodies against 2 hemidesmosome-associated proteins, BP180 and BP230. The immunopathologic features of BP can be ...
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Human plasma kallikrein releases neutrophil elastase during blood coagulation
... stimulate neutrophil chemotaxis, aggregation, and oxygen ...release neutrophil elastase was ...and elastase release was measured by both an enzyme-linked immunosorbent assay, and an enzymatic ...
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Oxidative regulation of neutrophil elastase alpha 1 proteinase inhibitor interactions
... released neutrophil elastase was not complexed with the antiproteinase and that a portion of the alpha-1-PI had undergone ...free neutrophil elastase as well as inactive, oxidized, and ...
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Stoll, Anja (2007): Purification and Partial Characterization of Canine Neutrophil Elastase and the Development of an Immunoassay for the Measurement of Neutrophil Elastase Concentration in Serum. Dissertation, LMU München: Tierärztliche Fakultät
... Twenty µg of purified cNE were transferred onto a PVDF membrane using the ProSorb™ sample preparation cartridge. The protein transfer was done according to the manufacture's protocol. The sample was analyzed at the ...
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Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in three-dimensional collagen gels
... Background: Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, “Fibroblasts and monocytes contract and degrade ...
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Clinical utility of the neutrophil elastase inhibitor sivelestat for the treatment of acute respiratory distress syndrome
... Acute respiratory distress syndrome (ARDS) is a serious acute hypoxic condition that develops in patients with various underlying diseases and injuries. There is a relative lack of treatment options for ARDS, although ...
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<p>Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies</p>
... of neutrophil elastase in the mucosa of UC patients, along with its speci fi c inhibition by ela fi n ex ...that elastase and elastinolytic activity are increased in IBD, contributing to ECM ...24,25 ...
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Neutrophil mediated injury to endothelial cells Enhancement by endotoxin and essential role of neutrophil elastase
... human neutrophil elastase, and different from that induced by hydrogen peroxide ...Further, neutrophil-mediated injury was not inhibited by scavengers of a variety of oxygen radical species, and ...
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Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha 2 macroglobulin
... the elastase and antielastase activity of the alveolar fluid of seven patients with the adult respiratory distress syndrome (ARDS) and thirteen normal ...antineutrophil elastase activity was also ...
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Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents
... pancreatic elastase, trypsin, chymotrypsin, and ...responses. Neutrophil and pancreatic elastase had little or no effect on PGI2 ...by neutrophil elastase (3-30 ...micrograms/ml ...
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Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease
... identified neutrophil elastase (NE), a major product released from neutrophils in inflamed airways, as a key risk factor for the onset and early progression of CF lung ...macrophage elastase (matrix ...
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Susceptibility of lung epithelium to neutrophil elastase: protection by native inhibitors
... Historically neutrophil elastase (NE) has been regarded as the primary mediator of tissue damage which occurs during pulmonary em- physema, notably by degradation of extracellu- lar ...
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Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women
... Leukoprotease activity was first described early in the 20 th century but human neutrophil elastase (NE) was only identified relatively recently [6]. Intracellular NE is a key effector molecule of the ...
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Neutrophil Elastase Inhibitors and Chronic Kidney Disease
... between neutrophil release and retention [15, 25, ...and neutrophil release into the circulation [25, ...for neutrophil chemotaxis ...aberrant neutrophil migration and to an increase of ...
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Modulation of dendritic cells by human neutrophil elastase and its inhibitors in pulmonary inflammation
... monocyte/neutrophil elastase inhibitor) required to inhibit 90% equivalent NE activity in CF ...(e.g., elastase and alkaline protease) considered as important virulence factors, which are able to ...
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Neutrophil elastase as a biomarker for bacterial infection in COPD
... All academic authors have completed the ICMJE uniform disclosure form and declare no financial support from, or relationship with any organisation that may have an interest, for the submitted work. MB has received travel ...
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Neutrophil elastase in bronchiectasis
... A complex interaction among proteases and anti- proteases is required for an effective respiratory immune system. Lower airways in patients with neutrophil elastase-mediated lung diseases are characterized ...
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Development of an assay for in vivo human neutrophil elastase activity Increased elastase activity in patients with alpha 1 proteinase inhibitor deficiency
... human neutrophil elastase (HNE) by the following criteria: activity was completely blocked by a specific HNE inhibitor or by adsorbing HNE from the extracts with a monospecific antibody and reconstitution ...
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Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium
... A common denominator of neutrophil-rich lung inflam- matory diseases (e.g., ALI/ARDS, CF, non-CF bronchiec- tasis) is epithelial injury. Thus, cleavage of E-cad by neutrophil-derived NE, whose level and ...
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