Neutrophil Infiltration
Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes
... chronic neutrophil infiltration, advancing microglial and astroglial re- action and apoptosis of neutrophils but no significant damage to neurons, myelin or ...
12
Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemia
... Deficiencies in endothelin-1 and endoglin expression were also revealed in Wsh compared to WT mice after focal ischemia. In both experimental and human stroke, the vasoconstrictor endothelin-1 is widely regarded to ...
34
In vivo expression of neutrophil inhibitory factor via gene transfer prevents lipopolysaccharide induced lung neutrophil infiltration and injury by a beta2 integrin dependent mechanism
... In establishing the model of LPS-induced lung PMN infil- tration, we showed that i.p. injection of LPS in mice resulted in a time-dependent increase in lung tissue MPO activity, which peaked 2 h after LPS challenge, and ...
12
CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma
... mediate neutrophil migration in models of mouse lung inflammation and experimental arthritis ...regulating neutrophil inflation in HCC tumors, which might further influence patient prognoses by facilitating ...
10
Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation
... lular infiltration to a local inflammatory stimulus of the ...trophil infiltration to an inflamed area of the skin that is not due to increased numbers of available neutrophils in the bone marrow or spleen ...
13
Strain Differences in Alveolar Neutrophil Infiltration and Macrophage Phenotypes in an Acute Lung Inflammation Model
... as KC and MIP-2. These observations differ from those previously described in studies of acute inflammation in the synovial-like air pouch using car- rageenan challenge (19,20), raising the possibility of tissue-specific ...
10
Original Article Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodent model of intestinal ischemia reperfusion by inhibiting the pathway of NF-Kb
... of neutrophil recruitment/infiltration, which also induced rise of MPO level and decline of ...and neutrophil infiltration in the lung tissue were improved observably; BALF content was ...
9
PubMedCentral-PMC5003671.pdf
... The humanized NC16A mice were generated as described [30]. A 50 μl aliquot of sterile IgG (control human IgG or affinity-purified NC16A-specific IgG) in PBS was administered to neonatal mice by intradermal or ...
20
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
... a neutrophil-recruiting DAMP following ...controlling neutrophil infiltration and inflammation following necrosis was observed in 2 clinically relevant necrosis models and was further highlighted by ...
12
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils
... CNS neutrophil infiltration (Figure 1A). Although neutrophil-derived IL-17 has been implicated in enhan- cing tissue damage during reperfusion injury [39], these data suggest that neutrophils ...
15
Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation
... increased neutrophil seems not associated with the changes of traditional chemokines, because the expression of various chemokines, including CCL4, CCL3, CXCL2 and ICAM-1, had no change between WT and DJ-1 KO mice ...
11
TRPV1 Ablation Aggravates Inflammatory Responses and Organ Damage during Endotoxic Shock
... ing neutrophil recruitment to the afflicted ...radicals, neutrophil-specific pro- teases, and products of lipid peroxidation, many of which are in- jurious to cells and may lead to irreversible organ damage ...
8
Neurotensin is a proinflammatory neuropeptide in colonic inflammation
... 1). Neutrophil infiltration, congestion and edema, and epithelial cell damage correlated temporally with changes in permeability and fluid secretion (Table ...
8
Anti inflammatory and burn injury wound healing properties of the shell of Haliotis diversicolor
... group, neutrophil infiltration was observed, indicating that the wound was still inflamed ...and neutrophil infiltrations were still observed in these two ...
12
Original Article Sarcandra glabra attenuates LPS-induced acute lung injury via inhibiting inflammation in rats
... lung, neutrophil infiltration into the lungs which was assessed by MPO activity in lung homogenates, pulmonary edema which was assessed by lung index and W/D weight ratio, respiratory disorder which was ...
9
The HMGB1/RAGE axis triggers neutrophil mediated injury amplification following necrosis
... massive neutrophil infiltration and often results in life-threatening acute liver failure, we did not study its contribution to disease processes in other organs or in other ...reduced neutrophil ...
13
Topical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammation
... Methods: A 50% (wt:vol) ethanolic solution of commercial 200:1 PCE was applied to both ears of female Swiss mice (n = 8) at 0.075, 0.15, 0.3, 1.25 and 2.5 mg/ear 30 min after TPA administration (2 µg/ear). For ...
7
PubMedCentral-PMC5010788.pdf
... hepatic neutrophil infiltration in chronically ethanol-fed mice 22, 23 or in high-fat diet fed ...hepatic neutrophil infiltration, fibrosis, ductular reaction, splenomegaly, hypoalbuminemia, ...
20
CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
... in neutrophil infiltration follow- ing dsRNA treatment are consistent with findings from previous studies using a live virus that also resulted in early neutrophil infiltration ...whether ...
14
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury
... lung injury (Fig. 3c, d). We performed the Evans Blue assay to measure vascular permeability to assess the degree of vascular leakage. At baseline, vascular perme- ability in Cdc42-KO lungs was significantly decreased ...
11