New World Arenavirus
The New World arenavirus Tacaribe virus induces caspase dependent apoptosis in infected cells
... Induction of apoptosis in Vero cells by Newcastle disease virus requires viral replication, de-novo protein synthesis and caspase activation.. Caspase cleavage of viral proteins, another[r] ...
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Differential Recognition of Old World and New World Arenavirus Envelope Glycoproteins by Subtilisin Kexin Isozyme 1 (SKI-1)/Site 1 Protease (S1P)
... AISRRLL-MCA). Peptides at a 25 M concentration were di- gested in vitro with soluble WT and Y285A mutant SKI-1/S1P in buffer solution at pH 7.5, and processing was evaluated by moni- toring the release of AMC over ...
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New World Arenavirus Clade C, but Not Clade A and B Viruses, Utilizes α-Dystroglycan as Its Major Receptor
... Old World arenaviruses has been iden- tified recently as ...the New World arenaviruses and Ippy virus, an Old World arenavirus not included in the earlier ...the New World ...
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The Z Protein of the New World Arenavirus Tacaribe Virus Has Bona Fide Budding Activity That Does Not Depend on Known Late Domain Motifs
... Old World virus Lassa virus (LASV) and several New World (NW) arenaviruses cause hemorrhagic fever (HF) disease in humans, posing a serious public health problem ...
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Investigation of Clade B New World Arenavirus Tropism by Using Chimeric GP1 Proteins
... blotting (Fig. 2B). GPs of the T(J) series were detected using an anti-GP2 rabbit polyclonal antibody raised against peptide CDMLRLFYNKNAIKTLN (Covance, San Diego, CA), while G(A) and A(G) chimeras were constructed with ...
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Highly Pathogenic New World Arenavirus Infection Activates the Pattern Recognition Receptor Protein Kinase R without Attenuating Virus Replication in Human Cells
... NW arenavirus JUNV and MACV infections, in contrast to the OW LASV, readily elicit an IFN response in human cells (21), which is consistent with clinical and animal study ...of arenavirus contain a ...
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A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR)
... of arenavirus NPs is to encapsidate the viral genomic RNA and aid the viral polymerase in the process of genome replication ...of arenavirus NPs to engage in protein-protein interactions with host cellular ...
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Identification of a Broad-Spectrum Arenavirus Entry Inhibitor
... B New World arenavi- ruses, the phylogenetic cluster containing all four South Amer- ican hemorrhagic fever viruses currently designated category A (JUNV, MACV, Guanarito virus, and Sabia ´ ...prototypic ...
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Inhibition of Arenavirus by A3, a Pyrimidine Biosynthesis Inhibitor
... To further examine the broad antiarenaviral activity of A3, we determined whether A3 inhibited multiplication of the New World arenavirus JUNV. For this, we examined the effect of A3 on cells ...
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Z Proteins of New World Arenaviruses Bind RIG-I and Interfere with Type I Interferon Induction
... New World arenavirus Z proteins impede NF- B and IRF-3 activity. RIG-I signaling activates transcription factors NF- B and IRF-3 via MAVS binding. We examined the activity of endogenous NF- B ...
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Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization
... Old World and New World arenavirus glyco- proteins in that the LCMV Armstrong strain (Arm-4) glycopro- tein does not utilize basic residues within the GP2 cytoplasmic domain as the driving ...
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A new development model for a “full” world
... the world. The financial world is, in essence, a set of markers for goods, services, and risks in the real world, and when those markers are allowed to deviate too far from reality,‘adjustments’must ...
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Middle East: New Balkans of the World?
... Middle East is a region whose geopolitical dynamics has many analogies with the role of the Balkans in the first half of the 19th century and up to the 3rd decade of the 20th century, namely a "Powder keg of ...
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Thermodynamic Isolation and the New World Order
... Magnetization: Similarly, human insight is limited in foreseeing the emergence of higher order in a piece of iron that is being cooled. Above the Curie point the atoms vibrate wildly; below it they calm down. As the ...
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Spaniards, cannibals and the eucharist in the New World
... Many of the interpretative routes we can follow to explain this web of associations are by now clearly marked. It is evident, to begin with, that the claim that Indians were cannibals formed part of a larger European ...
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The Brave New World of Carbon Trading
... One response to the problems with CDMs has been the “Gold Standard” offset, which began as an attempt by the World Wide Fund for Nature to evaluate additionality and address concerns over neglected environmental ...
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America_Ch 01-New World Encounters.pdf
... European monarchs adopted a new economic policy, known as mercan>lism, aimed at strengthening their naConal economies. According the mercanClism, a naCon’s real wealth is measured in its gold and silver ...
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Is There a Place for Children in the New World Order
... responsibility of health, mental health, community planning, justice, and education agencies for research and program development has been neglected, because responsibi[r] ...
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Accountability in the "Brave New World" of Development
... Neo-conservative rights are based on the inherent justice of marketplace exchanges. The right and the good must emerge from agreement among "free men," from playin[r] ...
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The New World Order And Rising Expectations
... Afri c a is to promote Pan African national- ism , to bring about unity, stabi l ity , and a sense of identity among Pan African peo- ples and to participate in the demand by Pan African[r] ...
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