NF-κ B
Single TNFα trimers mediating NF-κ B activation: stochastic robustness of NF-κ B signaling
... factor NF- κ B is a major mediator of innate immune responses ...cells NF- κ B is sequestered in the cytoplasm by dimerization with inhibitory proteins called I κ ...I ...
20
Minocycline impairs TNF-α-induced cell fusion of M13SV1-Cre cells with MDA-MB-435-pFDR1 cells by suppressing NF-κB transcriptional activity and its induction of target-gene expression of fusion-relevant factors
... of NF-κB activity is well known and has been reported in several studies [24, 28, 60, ...exactly NF-κB activity is blocked by minocycline. Song et al. showed that NF-κB was downregulated in rat ...
20
Role of the NFκB-signaling pathway in cancer
... the NF κ B-signaling pathway, targeting different key points along the cascade offers a major ...of NF κ B inhibitors being applied in clinical intervention as novel ...
11
Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
... 5-hydroxytryptamine, serotonin; BDNF, brain-derived neurotrophic factor; CDK5, cyclin-dependent kinase 5; GSK-3 β , glycogen synthase kinase-3 β ; IKK, I κ B kinase; NF- κ B, nuclear fac[r] ...
7
Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization
... Background: The accumulation of M1-polarized macrophages and excessive inflammation are important in the pathogenesis of diabetic foot ulcer (DFU). However, the underlying mechanism of DFU pathogenesis and the crucial ...
15
Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
... of NF- κ B as well as an increase in copper–zinc superoxide dismutase (Cu-Zn SOD) expres- ...and NF- κ B nuclear translocation ...
10
Myeloid cell-derived LL-37 promotes lung cancer growth by activating Wnt/β-catenin signaling
... kinase B; Gsk3β: glycogen synthase kinase 3β; TLR4: toll-like receptor 4; TLR2: toll-like receptor 2; TTP: tristetraprolin; TME: tumor microenvironment; AMPs: antimicrobial peptides; EGFR: epidermal growth factor ...
15
Inflammatory gene mRNA expression in human peripheral blood and its association with colorectal cancer
... , NF- κ B and IL-6 genes was significantly (p < ..., NF- κ B and IL-6 genes was, respectively, ..., NF- κ B and IL-6 genes, we found significant positive ...
7
Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy
... Abbreviations: DR, diabetic retinopathy; MAPK, mitogen-activated protein kinase; NF- κ B, nuclear factor- κ B; PI3K, phosphoinositide 3-kinase; RPE, retinal pigment epithelium; TIMP, t[r] ...
12
The role of heme oxygenase-1 (HO-1) in the regulation of inflammatory reaction, neuronal cell proliferation and apoptosis in rats after intracerebral hemorrhage (ICH)
... state, NF- κ B and I κ B α upstream signaling protein form complex in the ...I κ B degrades after phosphorylation and separates with NF- κ B ...p65. ...
9
Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state
... p-I κ B (1:1,000), I κ B (1:1,000), p-NF κ B (1:1,000), and NF- κ B (1:1,000), overnight at 4 ° ...
9
Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation
... Recently, PPM1A has attracted increasing interest owing to its tumor suppressor-like activity. Lu et al. [18] found that decreased PPM1A expression enhances prostate can- cer metastasis and this, at least partially, ...
13
NF-κB as a therapeutic target in cancer.pdf
... that NF- κ B can promote metastasis ...As NF- κ B positively regulates TNF gene expression and as TNF activates NF- κ B [1,2], these results might correlate ...
5
Up-regulation of COX-2/PGE2 by endothelin-1 via MAPK-dependent NF-κB pathway in mouse brain microvascular endothelial cells
... NF- κ B is required for ET-1-induced COX-2 expression ET-1 has been shown to modulate cellular functions through activation of NF-κB signaling in various cell types ...of NF-κB is ...
14
<p>Studies on the treatment of melanoma with folate acid conjugated dextran and lauryl alcohol loaded with IMD0354</p>
... Dex, LA, DMSO, BSA, MTT, and FA were purchased from Sigma (St. Louis, MO, USA). NF- κ B and p65 were provided by Lifecore Biomedical (Chaska, MN, USA). Murine B16F10 and L929 cells were obtained from ...
9
TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways
... dnI κ B- α : dominant negative inhibitor of NF- κ B translocation; EC: epithelial cell; ERK1/2: extracellular signal- regulated kinase 1/2; GM-CSF: granulocyte ...
8
Nuclear factor-kappa B influences early phase of compensatory lung growth after pneumonectomy in mice
... the NF-κB protein expression was transiently but signifi- cantly increased at 12 h after pneumonectomy prior to decreasing to non-significant levels at 48 h after pneu- ...the NF- κ B was ...
10
Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway
... κ B, leading the NF- κ B / I κ B complex sequesters in the cytoplasm, and prevents NF- κ B from binding to ...activate NF- κ B ...
12
<p>RBPJ inhibits the movability of endometrial carcinoma cells by miR-155/NF-κB/ROS pathway</p>
... Background: Recombination signal-binding protein J (RBPJ) is a crucial downstream effector of Notch signaling, which is involved cell proliferation, differentiation, and apoptosis. It plays an important role in ...
10
Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle
... Akt-regulated NF- κ B and Bad signaling pathway and its downstream ...regulating NF – κ B, which damage the normal cells, and induction of apoptosis in liver cancer by ...
20