NF-κB inducing kinase
Original Article Expression of NF-κB-inducing kinase in breast carcinoma tissue and its clinical significance
... Additionally, NF-κB expression has been found to be closely associated with the pathological grade and clinical stage of patients; the five- year survival rate is significantly lower in patients with ...
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NF κB–inducing kinase plays an essential T cell–intrinsic role in graft versus host disease and lethal autoimmunity in mice
... NF-κB–inducing kinase (NIK) is an essential upstream kinase in noncanonical NF-κB ...dent NF-κB activation downstream of several TNF receptor family members ...
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Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice
... NF-κB-inducing kinase (NIK) is a widely expressed Ser/Thr kinase that functions as a central mediator of noncanonical NF-κB activation [4]; however, its expression is ...
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Original Article Knockdown of NF-κB-inducing kinase prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns
... necessary. NF-κB- inducing kinase (NIK) is a ubiquitously-expressed kinase and is activated by diverse ...non-canonical NF-κB pathway, the related pro- inflammation ...
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Hepatitis C Virus Infection Induces Hepatic Expression of NF κB Inducing Kinase and Lipogenesis by Downregulating miR 122
... site within its 3= UTR. To confirm whether miR-122 targets NIK, we tested a NIK 3= UTR construct that contains a luciferase reporter gene directly upstream of the 3= UTR (Fig. 6A). NUAK2, a previously known miR-122 target ...
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Activation of NF-κB by the Kaposi's Sarcoma-Associated Herpesvirus K15 Protein Involves Recruitment of the NF-κB-Inducing Kinase, IκB Kinases, and Phosphorylation of p65
... of NF- B proteins to their target DNA ...the NF-B pathway and that this is at least partially dependent on the phosphorylation of tyrosine 481 in the SH2-B motif (Y 481 EEV) of the cytoplasmic domain of ...
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NF κB–inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis
... RA. NF- kB–inducing kinase (NIK) is a key mediator of the alternative arm of the NF-kB pathway, which is characterized by the nuclear translocation of RelB/p52 ...of NF-kB ...
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Beyond NF-κB activation: nuclear functions of IκB kinase α
... mediates NF-κB-dependent gene transcription, regardless of IκBα degradation, by enhancing transactivation [25] and DNA binding [30] of p65 as well as chromatin regula- tion through its interaction ...
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IKK/NF κB signaling: balancing life and death – a new approach to cancer therapy
... IκB kinase/NF-κB (IKK/NF-κB) signaling pathways play critical roles in a variety of physiological and pathological ...of NF-κB is promotion of cell survival through ...
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Functional Multigenomic Screening of Human Associated Bacteria for NF κB Inducing Bioactive Effectors
... MG1655, was also included in this analysis. The complete list of accession numbers for these strains is presented in Table S6. The nucleotide sequences found between kbl and rpmBG genes (49) were extracted as fasta files ...
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IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance
... that NF-κB is not highly active in normal brain tissue, we first compared the growth of normal neural stem cells and astrocytes to that of patient-derived GBM explant ...by NF-κB inhibition ...
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Original Article Exercise preconditioning attenuates pressure overload-induced pathological cardiac hypertrophy
... decreased NF-κB p65 subunit levels in the nuclear fraction, and then reduced IL2 levels in the myocardium of rats subject to ...the NF-κB signaling pathway in the early stage of pathological ...
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Osmotic stress activates JNK while blocking NF-kB pathway, and modulates immune responses
... factor-β-activated kinase 1 (TAK1) is a member of the MAPKKK family and plays an essential role in tumor necrosis factor (TNF), interleukin 1 (IL-1), and Toll- like receptor (TLR) signaling pathways ...
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Crosstalk between the canonical NF κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice
... in initiated pre-malignant epithelial cells substantially delayed pancreatic oncogenesis and resulted in down- regulation of the classical Notch target genes Hes1 and Hey1. Tnf-α stimulated canonical NF-κB ...
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Original Article Ruscogenin exerts beneficial effects on monocrotaline-induced pulmonary hypertension by inhibiting NF-κB expression
... the NF-κB signaling path- way ...of NF-κB p65, which indicates that ruscogenin may be used as a potential therapeutic agent for acute lung injury (ALI) or sepsis ...
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Curcumin attenuates MSU crystal induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
... induced inflammation, we investigated the effect of cur- cumin on IκBα, an inhibitor of NF-κB. Our results indi- cated that accelerated degradation of IκBα and elevated expression of p-p65 and p-p50 was ...
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Immunohistochemical Expression of Nuclear Factor – Kappa B in Oral Squamous Cell Carcinoma, Oral Submucous Fibrosis and Normal Mucosa
... of NF- κ B in oncogenic transformation was derived from the fact that v - Rel, a highly oncogenic retroviral homologue of c – Rel leads to carcinogenesis of avian lymphoid cells 41,45 ...of NF – κ B ...
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NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells
... of NF-κB/RelA and also disrupted its association with hypoxia inducible factor1 alpha (HIF1α), which is required for the binding of NF-κB/ RelA to the PKM promoter and PKM2 ...
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Original Article Ligustrazine attenuates LPS-induced endothelial dysfunction by inhibiting NF-κB pathways
... of NF-κB and sus- tained releasing of proinflam- matory cytokines could lead to endothelial dysfunction ...of NF-κB signals may be important in the forma- tion of atherosclerosis ...
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Computational modelling of NF-κB activation by IL-1RI and its co-receptor TILRR, predicts a role for Cytoskeletal Sequestration of IκBα in inflammatory signalling.
... Further analysis used the fast exchange model to simulate IL-1-induced NF-κB nuclear translocation and gene activity over longer stimulation times (Fig 3D). Results showed that, while the initial peaks were ...
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