NF-κB (Nuclear Factor κ-light-chain-enhancer of activated B cells)
Original Article Effects of NF-κB and hypoxia on the biological behavior of Y79 retinoblastoma cells
... and NF-κB on the expression of MMP- 2, MMP-9 and VEGF in retinoblastoma ...cancer cells was also increased. Further exami- nation revealed that when NF-κB was blocked by its specific ...
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Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia
... To this end, modulating the expression of micro- RNAs (miRNAs)—short non-coding RNAs that post- transcriptionally regulate target mRNAs)—has shown promise as a therapeutic tool for various human CNS disease states [10]. ...
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Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons
... canonical NF-κB pathway [14, 16, 43, 44], while the effect of PD-associated LRRK2 mutations is less clear [14, ...the NF- κ B cascade [14 – 16, 44 – ...of NF- κ B ...
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Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
... The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) proteins are a family of ubiquitously expressed transcription factors that ...
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Effects of intratracheal administration of nuclear factor-kappaB decoy oligodeoxynucleotides on long-term cigarette smoke-induced lung inflammation and pathology in mice
... with NF-κB decoy ...non-dependent NF-κB pathway in smoke-induced mice ...particular, NF-κB site is indispensable for the sup- pressive activity of TGF-β in the regulation of ...
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Original Article EGCG suppresses NF- B activation induced by gastroesophageal reflux contents in human esophageal epithelial cells
... the nuclear factor kappa-light-chain- enhancer of activated B cells (NF-κB) signaling pathway in normal human esophageal epithelial cells ...
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Cold shock proteins: from cellular mechanisms to pathophysiology and disease
... of NF-κB potentiates its acetylation [202], it will be interesting to see whether a similar effect is also found for the acetylation of ...Th2 cells) awaiting ...such cells on both the ...
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Renal interstitial fibrosis induced by high-dose mesoporous silica nanoparticles via the NF-κB signaling pathway
... inflammation. Nuclear factor kappa B (NF-κB), a com- mon rapid transcription factor associated with inflammation, plays an important role in the process of many kidney ...the ...
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The roles of the classical and alternative nuclear factor kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis
... T cells destroy the target cells (for example, in type 1 diabetes pancreatic β cells are destroyed), in autoimmune arthritis in SKG mice (and in RA in humans) the self-reactive T cells do not ...
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Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
... growth factor starvation ...transcription factor nuclear factor kappa B (NF-κB) in a subset of aged cells and plays a role in mediating inflammatory ...
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Original Article Impact of Bay 11-7085 on radiosensitivity of pancreatic cancer cell line Sw1990
... of nuclear factor kappa light chain en- hancer of activated B cells (NF-κB), on the radiosensitivity of human pancreatic cancer cell line Sw1990, and to ...
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Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle
... and cells of liver cancer were used as a model to investigate the molecular mechanism of Akt-associated inflammatory and apoptotic signaling pathway linked with NF-κB and Bcl-2-associated death ...
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Inhibition of osteoclastogenesis by RNA interference targeting RANK
... mitogen- activated kinases ...the activated RANK receptor and starts the NF-κB pathway, which finally leads to activation of osteoclastogenesis ...of NF-κB ligand (RANKL) ...
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IAP proteins as targets for drug development in oncology
... IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; IAPs, inhibitors of apoptosis; IL, interleukin; IKK, IκB kinase complex; LUBAC, linear ...
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Anti-inflammatory effects of prunin on UVB-irradiated human keratinocytes
... HaCaT cells to 40 mJ/ cm 2 UVB leads to an increase in ...HaCaT cells in a concentration-dependent manner, in- hibits the increased cellular aging caused by UVB, and is effective for ROS ...these ...
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... PC12 cells using corticosterone to investigate the effect of ketamine and nuclear factor-κB (NF-κB) on the cell viability, apoptosis, levels of pro-inflammatory cytokines, ...
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The case for intraocular delivery of PPAR agonists in the treatment of diabetic retinopathy
... AGE-induced NF-κB activation in animal mod- els ...RPE cells under hyperglycaemic conditions found that fenofibrate reduced RPE monolayer perme- ability [52] via blocking activation of ...
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Dermatan sulfate activates nuclear factor κb and induces endothelial and circulating intercellular adhesion molecule 1
... endothelial cells stimulated by DS in ...target cells and/or tissues or a difference in cellular responsive- ness despite similarities in NF-κB activation and ICAM- 1 ...
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Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation
... uninfected cells as indi- cated by the immunoblots. Cells were further separated into nuclear and cytoplasmic ...e, nuclear expression of PPM1A decreased more dramatically than total PPM1A, ...
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Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy
... on NF- κ B would be ...activate NF- κ B in unstimulated ...the NF- κ B-activating soluble peptides that are formed initially during hydrolysis are being ...
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