NGF/TrkA
Mueller, Markus (2005): In vivo function of NGF/TrkA signaling in the cholinergic neurons of the murine basal forebrain. Dissertation, LMU München: Fakultät für Biologie
... Thus, NGF signaling appears to be essential during the perinatal period to ensure cell survival, while later in life it may play a crucial role in promoting and maintaining proper cholinergic target ...
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The dynamics of trkA expression in the bovine ovary are associated with a luteotrophic effect of ovulation-inducing factor/nerve growth factor (OIF/NGF)
... Beta NGF is a homodimer with a molecular mass of 26–28 KDa [8], and was discovered in abundance in mouse sarcomas [9], snake venom [10], and mouse saliv- ary glands ...of NGF were initially thought to be ...
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The immunoreactivity of c-Fos, NGF and its receptor TrkA after open-field exposure in the central and medial nuclei of the rat amygdala
... of TrkA-ir cells was lower in comparison to those in the animals exposed to acute stress but similar to those of the control ...of NGF-high affinity receptors in the brain after exposure to long-lasting ...
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NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib
... with TrkA in NGF-treated cells (Table ...the TrkA/ CD44 complex, we used co-IP to investigate whether they directly ...upon NGF treatment, ROCK1 (the main target of RhoA and RhoC) was also ...
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TRAF4 mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis
... affects TrkA tyrosine phosphor- ...the NGF-induced signal transduction ...that TrkA ubiquitination at a different site regulates the receptor internalization ...in TrkA subcellular ...
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Original Article Characteristics of intestinal microflora involved insacral nerve stimulation affecting visceral hypersensitivity
... of NGF, TrKA, NF-κB, TRPV1, pTRPV1, IL-1β, IL-10, IL-22, TNF-α, 5-HT, and γ-GABA were measured in each ...of NGF and TrKA in the SNS stimulation model was higher than that in the antibiotic ...
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Role of nerve growth factor and its TRKA receptor in normal ovarian and epithelial ovarian cancer angiogenesis
... of TRKA, NGF induces an increase in the vascular endothelial growth factor (VEGF) expression ...cells, NGF and TRKA are also expressed [8], and the active form of TRKA has been ...
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Oxycodone regulates incision-induced activation of neurotrophic factors and receptors in an acute post-surgery pain rat model
... of NGF and TrkA are inhibited through the NT-3-TrkC pathway, inhibiting the downstream signaling and expression of the mediators induced by the NGF-TrkA ...
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Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders
... of NGF/TrkA ...Ulk1, TrkA, pTrkA, PHEV, and ...of TrkA was not significantly ...and TrkA intensities were normalized against the amount of GAPDH. (B) Cy3-NGF internalization ...
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Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain
... between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA develop- ...Since NGF blocking is an efficient way to ...
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Selective inhibition of tropomyosin receptor kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis
... of NGF on neuronal sensitisation [47]. NGF block- ade can lead to a reduction in pain behaviour without blocking inflammation [25, 27, 28], as demonstrated using various animal models of inflammatory or ...
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Seasonal changes in expression of nerve growth factor and its receptors TrkA and p75 in the ovary of wild ground squirrel (Citellus dauricus Brandt)
... study, NGF and its receptors, TrkA and p75 were immunolocalized in ovarian tissues during the breeding and nonbreeding period, and both mRNA and protein of NGF, TrkA and p75 were also ...
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Ablation of TrkA function in the immune system causes B cell abnormalities
... that TrkA, although modulating immune system functions, is not required for its normal ...that NGF injections cause their increase in various tissues of neonatal rats (Aloe and Levi-Montalcini, 1977; ...
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NGF – the TrkA to successful pain treatment
... incorporates NGF measurements in the relevant samples before and after treatment, in addition to collecting the pain ...establish NGF levels as a predictive biomarker for patients who can benefit from ...
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Identification and characterization of the Cucurbitacins, a novel class of small molecule inhibitors of Tropomyosin receptor kinase a
... against TrkA. TrkA, the surface transmembrane receptor tyro- sine kinase for the neurotrophin, nerve growth factor (NGF), plays an important role in the pathogenesis of psoriasis and associated ...
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A Spaetzle-like role for nerve growth factor beta in vertebrate immunity to Staphylococcus aureus
... whether NGF -TRKA signaling represents a critical, evolutionarily conserved component of vertebrate immunity to ...of trkA was confirmed by immunohistochemistry, where we observed the expected loss ...
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Nerve growth factor modulates the tumor cells migration in ovarian cancer through the WNT/β-catenin pathway
... of NGF/NGFRs and β-catenin in ovarian cancer cells. NGF acted as an autocrine or paracrine regulator of β-catenin which can decrease β-catenin expression and affect the activation status of β-catenin in ...
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A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target
... for TrkA in MCC [14, 15] but would negate a pro- posed requirement for NGF-expressing MCC-infiltrating inflammatory cells for activation [15], which may be more relevant to MCPyV negative MCCs, BCCs and ...
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Insights into Current Tropomyosin Receptor Kinase (TRK) inhibitors: development and clinical application
... survival. TRKA is activated by nerve growth factor (NGF), TRKB is activated by brain- derived neurotrophic factor (BDNF), and TRKC is activated by neurotrophin-3 ...
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NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line
... the TrkA receptor, which is a member of the TRK (tropomyosin-receptor kinase) family of receptor tyrosine kinases (RTKs) that also includes TrkB (encoded by NTRK2) and TrkC (encoded by NTRK3) ...conditions, ...
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