nicotinamide adenine dinucleotide (oxidized and reduced forms)
Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathways
... NADPH, nicotinamide adenine dinucleotide phosphate; ME1, malic enzyme 1; ME2, malic enzyme 2; BPTES, bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3; GLS1, glutaminase 1; MDH1, malate ...
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Verifying of Participation of Nitric Oxide in Morphine Place Conditioning in the Rat Medial Septum Using Nicotinamide Adenine Dinucleotide Phosphate-Diaphorase (NADPH-d)
... on morphine place conditioning in Wistar rats were examined. Morphine (2.5-7.5 mg/kg) was injected s.c. using a three-day schedule of an unbiased place preference. All of the brain samples were examined histochemically ...
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Original Article The effect of nicotinamide adenine dinucleotide (NADH) on electrical remodeling in atrial fibrillation
... Abstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in human. The aim of this study is to detect the effect and elucidate the molecular mechanism of nicotinamide adenine ...
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Nicotinamide adenine dinucleotide phosphate oxidase-mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells
... 16αOHE1-Induced Proliferation Involves Nox 16αOHE1 stimulated cell growth, as measured by 5-bromo- 2′-deoxyuridine incorporation in control hPASMCs and PAH- hPASMCs (Figure 5A). These effects were attenuated by Figure 1. ...
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Reduced nicotinamide adenine dinucleotide and the reduction of oxidized glutathione in human erythrocytes
... increased amounts of intracellular NAD. This regeneration of reduced glutathione could be explained by the generation of reduced nicotinamide adenine dinucleotide phosphate through the metabolism of ...
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Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell free system
... When both the supernate and pellet fractions were omitted, there was no superoxide production, thus establishing that the generation of superoxide was not due to some side reaction invol[r] ...
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In vitro activity of nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate linked 15 hydroxyprostaglandin dehydrogenases in placentas from normotensive and preeclamptic/eclamptic pregnancies
... If this increase were also expressed in vivo, its effect on prostaglandin metabolism could be mistaken for impaired prostacyclin biosynthesis unless both the 6-keto- and 6,15-diketo-meta[r] ...
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Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly Translocation of p47 phox and p67 phox requires interaction between p47 phox and cytochrome b558
... We have now studied the translocation process in neutrophils of patients with chronic granulomatous disease CGD, an inherited syndrome in which the oxidase system fails to produce supero[r] ...
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Modulation of nicotinamide adenine dinucleotide and poly(adenosine diphosphoribose) metabolism by the synthetic "C" nucleoside analogs, tiazofurin and selenazofurin A new strategy for cancer chemotherapy
... nicotinamide and its conversion to NAD, we showed that the analogs interfere with NAD synthesis, apparently by blocking formation of nicotinamide mononucleotide. The analogs also serve as weak inhibitors of ...
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Possible role of nicotinamide adenine dinucleotide as an intracellular regulator of renal transport of phosphate in the rat
... modulator of the brush border membrane (BBM) transport of inorganic phosphate (Pi). NAD, both oxidized (NAD+) and reduced (NADH) form, inhibited the Na+-dependent uptake of 32Pi in the concentration range of 10-300 ...
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Effects of exogenous nicotinamide adenine dinucleotide (NAD+) in the rat heart are mediated by P2 purine receptors
... Exogenous extracellular NAD+ induced two opposite effects in LA and RA – quickly developing and transi- ent prolongation of APs ( “ positive ” effect) and delayed sustained AP shortening[r] ...
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Role of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid induced cytotoxicity in susceptible lymphoid cells
... These studies suggest that steroid-induced cytotoxicity in susceptible lymphocytes is due to the presence of DNA strand breaks that activate polyADP-ribose polymerase to a sufficient deg[r] ...
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Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH) oxidase by protein kinase C
... These studies demonstrate that phorbol esters stimulate the neutrophil respiratory burst through activation of cytosolic protein kinase C, which in turn activates either a regulatory con[r] ...
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Oxidative Stress Is Associated With Arterial Dysfunction and Enhanced Intima-Media Thickness in Children With Hypercholesterolemia: The Potential Role of Nicotinamide-Adenine Dinucleotide Phosphate Oxidase
... We performed a cross-sectional study comparing flow-mediated dilation, intima-media thickness, lipid profile, urinary isoprostanes as markers of oxidative stress, and platelet expression[r] ...
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Chronic granulomatous disease due to a defect in the cytosolic factor required for nicotinamide adenine dinucleotide phosphate oxidase activation
... Table L Cell-free Activation of NADPH Oxidase in Autosomal Recessive, Cytochrome b-positive CGD Neutrophils Source of fraction Cytosol factor.. Oj generation Membranes.[r] ...
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Streptozotocin Diabetes CORRELATION WITH EXTENT OF DEPRESSION OF PANCREATIC ISLET NICOTINAMIDE ADENINE DINUCLEOTIDE
... Peak plasma N-nitroso intact streptozotocin and MNU concentrations after intraperitoneal administration at graded doses are correlated with islet NAD content at 3 h post-injection and wi[r] ...
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Oxidant injury of cells DNA strand breaks activate polyadenosine diphosphate ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide
... To determine the biochemical basis of the oxidant-induced injury of cells, we have studied early changes after exposure of P388D1 murine macrophages to hydrogen peroxide. Total intracellular NAD+ levels in P388D1 cells ...
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Deficiency of the iron sulfur clusters of mitochondrial reduced nicotinamide adenine dinucleotide ubiquinone oxidoreductase (complex I) in an infant with congenital lactic acidosis
... We report the case of an infant with hypoglycemia, progressive lactic acidosis, an increased serum lactate/pyruvate ratio, and elevated plasma alanine, who had a moderate to profound decrease in the ability of ...
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Glucose regulation of hydroperoxide metabolism in rat intestinal cells Stimulation of reduced nicotinamide adenine dinucleotide phosphate supply
... The stimulation of NADPH production with exogenous glucose further suggests that the flux of endogenous glucose through the pentose phosphate shunt is low, consistent with a preferential[r] ...
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Changes in the microstructure of compact and trabecular bone tissues of mice subchronically exposed to alcohol
... NADPH: nicotinamide adenine dinucleotide phosphate; µm: micrometre; μCT: microcomputed tomography; BV/TV: relative bone volume; BV/TV*: relative bone volume without marrow cavity; ...
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