NITRIC OXIDE AND APOPTOSIS:
Nitric oxide prevents H2O2-induced apoptosis in SK-N-MC human neuroblastoma cells
... Nitric oxide (NO) is a cellular signaling molecule in many physiological and pathological processes including ...of apoptosis by NO and ...cell apoptosis by suppressing apoptosis signal ...
11
IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide
... to apoptosis and endoplasmic reticulum (ER) stress was measured by reverse transcription-polymerase chain reaction ...(RT-PCR). Apoptosis and autophagy-related proteins were examined by Western blot ...
11
Nitric oxide factor, which regulates proliferation and apoptosis in the adult brain of amur sturgeon Acipenser schrenckii
... and apoptosis areas in the medulla oblongata, cerebellum, optic tectum, thalamus and hypothala- mus of Amur sturgeon Acipenser schrenckii was in- vestigated, using techniques of immunoperoxidase staining of ...
17
Differential expression of nitric oxide synthases in porcine aortic endothelial cells during LPS-induced apoptosis
... that nitric oxide (NO) is generated by a family of constitutively (nNOS and eNOS) or inducibly (iNOS) expressed enzymes and takes part in different aspects of the inflammatory response; nevertheless, its ...
9
Hsp90β inhibition modulates nitric oxide production and nitric oxide induced apoptosis in human chondrocytes
... Transfection of small interfering RNA (siRNA) For the silencing experiments we used a pre-plated transfection procedure. Approximately 72 hr before transfection, 8 × 10 4 healthy adherent cells were trypsi- nized and ...
11
Caspase-Mediated Apoptosis in Neuronal Excitotoxicity Triggered by Nitric Oxide
... We therefore designed this study to investigate whether triggering of caspase activity and/or activation of PARP played a role in cere- bellar granule cell (CGC) apoptosis elicited by pe[r] ...
15
The Effect of Nitric Oxide on Mouse Pre-Implantation Embryo Development and Apoptosis
... which can initiate apoptosis and cause cell death in various cell types [6-8]. It has been suggested that NO has important physiological roles in a variety of reproductive processes such as follicular development, ...
5
Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis
... and nitric oxide (NO), or anti-inflammatory, such as IL-10, IL-4, TGF-β, according to the microglia phenotype, which is highly dependent on the pathological context ...
12
Critical Role of Nitric Oxide During the Apoptosis of Peripheral Blood Leukocytes from Patients with AIDS
... These data suggest a role for iNOS-mediated endogenous NO genera- tion during the apoptosis of PBMC in AIDS patients having low peripheral CD4+ cell numbers. Effects of NO and L-arginine[r] ...
8
Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide
... Earlier studies with garlic were mainly aimed at the therapeutic potential of whole garlic homogenates [7]. However, there is no information on the potential of gar- lic skin; a papery covering surrounding the individual ...
10
Nitric oxide synthase and the contribution of nitric oxide to vertebrate motor control
... in apoptosis (Brune, 2003). Nitric oxide has been implicated as a metamodulator of locomotion and may play a part in the development of amphibian motor systems and their maturation (see McLean et ...
153
Nitric oxide for cancer therapy
... Organic nitrates Organic nitrates include compounds such as: glycer- yltrinitrate (GTN) and isosorbidedinitrate (ISDN). These are the oldest class of NO donors. Several stud- ies have demonstrated anticancer properties ...
9
Nitric oxide and cancer: a review
... Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in various physiological as well as pathological ...angiogenesis, apoptosis, cell cycle, invasion, and ...
11
The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches
... 7.2. Statins, Minocycline and NOS Inhibitors Regarding drug therapy, statins—which are widely used in the treatment of stroke and atherosclerosis—have been a research hotspot. It was found that simvastatin can ...
24
Nitric Oxide: It’s Role in Immunity
... Lower levels of NO/RNS act as anti-apoptotic factor. The S-nitrosylation of caspases blocks the process of apoptosis and prevents the degradation of anti apoptotic proteins, hence protects the cells from death. ...
5
NITRIC OXIDE: A NOVEL THERAPEUTIC TARGET
... Cross-talk between NO and micronutrients within and outside the gastrointestinal system affects the establishment or progression of several diseases with pressing medical needs. Some studies imply that NO has cytotoxic ...
13
Is Nitric Oxide a Hormone?
... appraisal of the Griess reaction in the L-arginine/nitric oxide area of research. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 851: 51-70. 33. Wennmalm, A., Benthin, G., Edlund, A., Jungersten, L., ...
7
Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides
... histochemical studies of RA synovium with antiserum against iNOS revealed that iNOS protein was strongly expressed in synovial lining cells, endothelial cells, and, to a lesser extent, i[r] ...
8
Nitric Oxide-Dependent Penile Erection in Mice Lacking Neuronal Nitric Oxide Synthase
... In cross sections of the proximal penis of the wild-type (A) and nNOS- mouse (B), staining of dorsal penile nerves (arrow) is observed only in the wild-type penis. Counterstaining with h[r] ...
9
Hypergravity upregulates renal inducible nitric oxide synthase expression and nitric oxide production
... dysfunction. Nitric oxide (NO), which is endogenously synthesized by inducible NO synthase (iNOS), plays an important role in the regulation of renal ...
8