Nitric-oxide Donor
ROLE OF NITRIC OXIDE DONOR AND PHOSPHODIESTERASE-II INHIBITOR IN A STREPTOZOTOCIN INDUCED DIABETIC NEPHROPATHY IN RATS
... a nitric oxide donor alone or combination with erythro-9-(2- hydroxy-3-nonyl) adenine, (EHNA), a Phosphodiesterase-II specific inhibitor in the reduction of various markers of nephropathy, reactive ...
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Use of Nitric Oxide Donor Isosorbide Mononitrate for Cervical Ripening at 41 Weeks’ Gestation
... Background: The ideal agent for cervical ripening would induce adequate cervical ripening with minimal adverse effects to the mother and the fetus; the most favorable method for cervical ri- pening is not fully agreed ...
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New nitric oxide donor drugs
... The finding that SNAG causes significant concentration dependent vasodilation of nutritive cutaneous microvessels is consistent with these blood vessels being responsive to exogenous NO. SNAG has a considerable advantage ...
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Effect of nitric oxide donor SNAP on GABA release from rat brain nerve terminals
... isolated rat brain nerve terminals (synaptosomes). As the NO donor, we used SNAP (S-nitroso-N- acetylpenicillamine), which belongs to the class of natu ral metabolite of nitric oxide. Biological ...
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The novel nitric oxide donor PDNO attenuates ovine ischemia-reperfusion induced renal failure
... Renal IRI is the result of direct ischemia causing acute tubular necrosis which subse- quently leads to decreased glomerular filtration pressure and tubular obstruction [20]. In addition, reperfusion brings ...
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<p>A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension</p>
... of nitric dioxide in reaction with ...NO donor drugs have reached the market, organic nitrates and sodium nitroprusside, but none are indicated for acute pulmonary hypertension due to adverse side ...
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Effect of treatment delay, stroke type, and thrombolysis on the effect of glyceryl trinitrate, a nitric oxide donor, on outcome after acute stroke: a systematic review and meta analysis of individual patient from randomised trials
... NO donor, reduced BP and platelet function and did not alter cerebral blood flow (CBF) ...NO donor studied most is glyceryl trinitrate (GTN), an organic nitrate licensed for the management of ...
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Original Article Nitric oxide donor, NOC7, reveals dose dependently and cGMP pathway independently biphasic effects on contractile force of isolated rat heart after global ischemia
... NO donor have biphasic effect on the con- tractile force of the isolated rat heart and main- ly embodied as concentration-dependent: The tiny concentration of NO donor can produce a positive inotropic ...
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Cytotoxic effects of a novel nitric oxide donor compound and oncogenic transformation of a human urothelial cell line
... cells. Nitric oxide (NO) h a s been a h o tsp o t of research in recent years and is a n a tu ra l p ro d u ct accounting for several sep arate biological functions w ithin the h u m an ...
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Pharmacology of reflex blinks in the rat: a novel model for headache research
... Developing a non-invasive migraine animal model that can reliably and easily demonstrate alterations of trigem- inal and brainstem function has been a long unmet need in the migraine research field. In this manuscript we ...
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Salmonella enterica biofilm-mediated dispersal by nitric oxide donors in association with cellulose nanocrystal hydrogels
... the nitric oxide donor technology, we focused on dispersing well-estab- lished biofilms in the shortest time ...of nitric oxide and a hydrogel was used, considering the attractive ...
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Dienel, Ari (2016): Veränderung der Mikrozirkulation nach experimenteller Subarachnoidalblutung (SAB): Kinetik, Bedeutung und Identifikation von Mechanismen. Dissertation, LMU München: Medizinische Fakultät
... Controlled release of a nitric oxide donor for the prevention of delayed cerebral vasospasm following experimental subarachnoid hemorrhage in nonhuman primates. Journa[r] ...
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Platelet derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction
... NADPH oxidase and uncoupled NO synthase are sources of reactive species from platelet-derived exosomes. Exosomes from septic patients, as well as exosomes induced with the nitric oxide donor ...
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Therapeutic potential of transdermal glyceryl trinitrate in the management of acute stroke
... The nitric oxide donor, glyceryl trinitrate (GTN), is a candidate treatment for the management of acute stroke with haemodynamic and potential reperfusion and neuro- protective ...
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Regulation of the Molt infradian Rhythm in Daphnia magna and its Disruption by Exogenous Chemicals.
... implicated nitric oxide in the regulation of the timing of this ...of nitric oxide and nitric oxide-mimicking chemicals can increase the molt infradian ...the nitric ...
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Structure-Function Changes of the Distal Outflow Tract in Response to Nitric Oxide
... a nitric oxide donor (100 µM DETA- NO) on outflow facility were compared to controls (n=8 per group) with trabecular meshwork (TM) and after circumferential ab interno trabeculectomy ...
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Design, Synthesis and biological evaluation of some novel indole derivatives as selective COX-2 inhibitors
... Diazen-1-ium-1, 2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3- trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: [r] ...
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Dual Nitrergic/Cholinergic Control of Short-Term Plasticity of Corticostriatal Inputs to Striatal Projection Neurons
... (Blomeley and Bracci, 2005), these experiments were carried out under voltage-clamp conditions. Bath application of SNAP caused a significant increase in the amplitude of the first evoked responses in 12/12 cholinergic ...
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Urinary Magnesium and Calcium Excretion after Neuronal Nitric Oxide Synthase Inhibition in Normotensive and Spontaneously Hypertensive Rats.
... rats nitric oxide generated by nNOS is not involved in the regulation of water, calcium and magnesium ...SHR nitric oxide generated by neuronal nitric oxide synthase participate ...
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A Critical Role of Nitric Oxide in Human Immunodeficiency Virus Type 1-Induced Hyperresponsiveness of Cultured Monocytes
... Recently, we demonstrated both induction of nitric oxide synthase (NOS) in and production of nitric oxide (NO) by HIV-1-infected mono-.. cytes (10).[r] ...
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