nitric oxide synthase inhibitor
The selective neuronal nitric oxide synthase inhibitor 7-nitroindazole has acute analgesic but not cumulative effects in a rat model of peripheral neuropathy
... enzyme nitric oxide synthase (nNOS) has been shown to be involved in the spinal transmission of nociception in animal models of chronic ...neuronal nitric oxide synthase, ...
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Influence of Nitric Oxide in the Central Amygdala on the Acquisition and Expression of Morphine-Induced Place Preference in Morphine Sensitized Rats
... a nitric oxide precursor, and NG-nitro-L-arginine methyl-ester (L NAME), a nitric oxide synthase inhibitor, on the morphine-induced sensitization and also on the expression of ...
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Nitric oxide production and perivascular nitration in brain after carbon monoxide poisoning in the rat
... Nitric oxide is a short-lived free radical and physiological mediator which has the potential to cause ...whether nitric oxide, and the potent oxidant peroxynitrite, were generated in brain ...
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Vascular control in larval Xenopus laevis: the role of endothelial derived factors
... The present study was undertaken to increase our understanding of the role of endothelial-derived factors in vascular control in a developing animals. Although the main function of blood circulation in small larvae such ...
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Key words
... endogenous inhibitor of all iso- forms of NO synthase, which was demonstrated in many experiments in vitro and in vivo [2, ...I) nitric oxide synthase are predominantly inhibited by ...
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Nitric oxide synthase and the contribution of nitric oxide to vertebrate motor control
... The role of NO on the maturation of motor systems in the spinal cord was subsequently explored further, again using organotypic culture methods. Xenopus CNSs at stage 47 were cultured in the presence of the NO donor ...
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Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle
... uricase inhibitor (oxonic acid) after sev- eral weeks of treatment ...nal nitric oxide synthase in the juxtaglomerular ...ACE inhibitor and to a lesser extent ...neural nitric ...
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Increased Levels of Asymmetric Dimethyl Arginine (ADMA) in Population at Risk for Cardiovascular Disease; A Study From Central India
... endogenous inhibitor of nitric oxide synthase, asymmetric dimetylarginine (ADMA), is elevated in patients with type-2 diabetes mellitus (DM) and has been related to atherosclerotic ...ADMA, ...
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Nitric oxide synthase lies downstream from vascular endothelial growth factor induced but not basic fibroblast growth factor induced angiogenesis
... Effect of soluble guanylate cyclase inhibition on the long- term replication and sprouting of CVEC in response to VEGF and bFGF. An involvement of the NO/cyclic GMP signaling pathway in mediating the longterm effects of ...
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Nitrite Derived from Endogenous Bacterial Nitric Oxide Synthase Activity Promotes Aerobic Respiration
... potent inhibitor of aerobic respiration and central metabolism due to its ability to react with heme centers, protein thiols, and Fe-S clusters in enzymes (8, ...
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Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress
... Results: Results showed that the 4-week UCMS significantly induced depressive-like behaviors, including decreased sucrose preference in a sucrose preference test, increased duration of immobility in a forced swim test, ...
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Nitric oxide regulation of the central aortae of the toad Bufo marinus occurs independently of the endothelium
... NOS inhibitor L -NNA abolished or significantly inhibited the response; the response was also abolished by the soluble GC inhibitor ...nNOS inhibitor, significantly inhibited the ...
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Role of nitric oxide in the gastrointestinal tract
... The mechanisms that underlie the ulcerogenic properties of NSAIDs are still being elucidated, but inhibition of mucosal prostaglandins is a key factor [13,14,17]. Various experi- mental models have shown that, in ...
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Serotonin and platelet studies in vascular disease
... n synthase (Johnson et ...y nitric oxide, NO) activates soluble g u anylate cyclase leading to the accumulation of cGMP in smooth m u s c l e cells and platelets w h i c h in turn causes relaxation ...
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Effect of L- Arginine, the Nitric Oxide Precursor, on Morphine Tolerance in Ovariectomized Rats
... endothelial nitric oxide synthase synthesis in the median eminence during the rat estrous cycle: an additional argument for the implication of vascular blood vessel in the control of GnRH ...
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Anti-inflammatory property of Parkia speciosa empty pod extract in human umbilical vein endothelial cells
... inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression as well as proinflammatory cytokines, like tumor necrosis factor-α (TNF-α) (Hsu et ...increase nitric ...
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Anti-inflammatory effect of ozonated krill (Euphausia superba) oil in lipopolysaccharide-stimulated RAW 264.7 macrophages
... Nitric oxide (NO) production in the culture medium was measured via the Griess reaction (Weissman and Gross 2001). After a 24 h pre-incubation of RAW 264.7 macrophages with various concentrations (10, 50, ...
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Compartmentalization of extracellular cGMP determines absorptive or secretory responses in the rat jejunum
... The major finding of this study was that the cGMP responses had opposite effects, depending on whether particulate guanylyl cyclase was stimulated from the mucosal side or whether soluble guanylyl cyclase was stim- ...
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TLR2 signal influences the iNOS/NO responses and worm development in C57BL/6J mice infected with Clonorchis sinensis
... 5]. Nitric oxide (NO) formation and nitrosation may contribute to the development of liver fluke-associated carcinogenesis ...by nitric oxide synthase ...
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Nitric Oxide/Peroxynitrite Redox Imbalance in Endothelial Cells Measured with Amperometric Nanosensors
... [7] J. L. Balligand, D. Ungureanu-Longrois, W. W. Simmons, D. Pimental, T. A. Malinski, M. Kapturczak et al., “Cy- tokine-Inducible Nitric Oxide Synthase (iNOS) Expres- sion in Cardiac Myocytes. ...
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