nitrogen heterocycles
Investigating Hydrothermal and Radiation Effects on Nitrogen Heterocycles Relevant to Meteorite Parent Bodies
... of nitrogen heterocycles. Initially, 15 nitrogen heterocycles were chosen for analysis as they are either known to be produced in room temperature cyanide reactions or are found in formic acid ...
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Tetrahydroquinolines and Isoxazoles: Nitrogen heterocycles as potential antibacterial agents
... Nitrogen heterocycles are a part of a special group of organic substances found in many biologically active natural and synthetic products with properties pharmacologically ...
6
Synthesis of nitrogen heterocycles via amidyl radical cyclisations
... A series of experiments have been performed in order to investigate the stereochemistry of amidyl radical cyclisations and the effect of the nitrogen substituent on the stereoselectivity. A preference for a trans ...
257
Copper (I) mediated radical cyclisation novel approaches to nitrogen heterocycles
... Tandem radical cyclisation reactions have been catalysed using copper I chlorideibipy.19 For example, reaction of trichloroamide 38 with this catalyst at 40°C gave the diastereomeric bic[r] ...
347
Synthesis and biological activity of nitrogen heterocycles from anthranilic acid derivative
... The product obtained was filtered off, washed with water, dried and purified by frictionally crystallization with proper solvent to give 6 and 7.. The reaction mixture was cooled and pou[r] ...
8
The syntheses and testing of some nitrogen heterocycles for interaction with benzodiazepine receptors
... CONTENTS Page Certificate of originality i Acknowledgements ii Nomenclature iii Summary iv CHAPTER I Introduction I-1 Pharmacology of benzodiazepinesand their receptors 1 I - 1.1 General[r] ...
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A radical approach to nitrogen heterocycles
... the nitrogen substituent was a methoxycarbonyl group It was assumed that the electronic nature of the nitrogen may affect the stereoselectivity although how this electronic effect influences the ...
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Kinetic and NMR studies of some nitrogen heterocycles
... Assuming that the pathway follows the route from (a) to (c), formation of the product (h) now follows either simultaneous or sequential loss of two water molecules. Three signals are expected to be observed in the ...
181
Synthesis of nitrogen heterocycles
... The method involves cyclizing a haloaryl alkene in the presence of a catalytically effective amount of a palladiumII ion source and in the presence of a cycliz ing promoting base such as[r] ...
7
Synthesis and evaluation of some nitrogen heterocycles as antimalarials
... N - [ 6 - ( 7 ,-Trifluoromethylquinolin-4’-yl)hex-5-en-l-yl]phthalimide (VII.38) 4-Bromo-7-trifluoromethylquinoline (2.3 g), A-(hex-5-en-l-yl)phthalimide (2.1 g), palladium acetate (0.020 g), tri-o-tolylphosphine (0.053 ...
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2-Iodoisatogens: Versatile Intermediates for the Synthesis of Nitrogen Heterocycles
... Dipolar compounds represent an important class of intermediate in organic synthesis, largely because of their potential to undergo cycloaddition reactions towards complex functionalized [r] ...
5
New approaches to nitrogen heterocycles via radical cyclisations
... After cooling, water 150 mL was added and the mixture was extracted with EtOAc 3 x 150 mL and the combined organic layers were dried over MgSO4, filtered, and concentrated in vacuo to gi[r] ...
293
A Multistep Preparation of 3-Aryl-8-Methoxythiazolo [3’, 2’ : 2, 3] [1, 2, 4] Triazino [5, 6-b] Indoles Under Microwave Ir-radiations
... Bridgehead nitrogen heterocycles containing thiazole and related heterocycles (thiadiazole and thiadiazine) exhibit antihistaminic, antithyroid, antitubercular, antifungal & antibacterial ...
5
Methyl (4 formyl 2 methoxycarbonylpyrrol 1 yl)acetate
... nitrogen heterocycles widely used in medicinal chemistry as well as the pharmaceutical and chemical industries and was selected for crystal structure determination in order to elucidate the conformation of ...
7
An Efficient Synthesis of Ethyl {[3-(hydroxymethyl) quinolin-2-yl]thio}acetate
... sulfur–nitrogen heterocycles includes highly stable aromatic compounds, that display physicochemical properties with relevance in the design of new materials especially those relating to molecular ...
5
Synthesis of some benzothiazolyl and imidazole derivatives and evaluation of antibacterial activities
... A short review of available literatures shows novel application of nitrogen heterocycles on human chronic myelogenous leukemia K562 cells [11]. Interestingly, the synthesized compound induced a biphasic ...
8
Application of four membered ring chalcogenation reagents to the synthesis of new phosphorus chalcogen heterocycles
... The reaction of four‐membered ring chalcogenation reagents such as Lawesson’s reagent, 2,4‐diferrocenyl‐ 1,3,2,4‐diathiadiphosphetane 2,4‐disulfide (the ferrocene analogy of Lawesson’s reagent) and Woollins’ reagent with ...
12
Formation and photostability of N-heterocycles in space. I. The effect of nitrogen on the photostability of small aromatic molecules
... Nucleobases are nitrogen-containing heterocyclic aromatic compounds (N-heterocycles), found in the genetic material of all living organisms on Earth. They can be divided into two groups according to their ...
8
Polyethylene glycol embedded tribromide as an efficient and reusable catalyst for the library synthesis of nitrogen containing heterocycles
... with KBr followed by the addition of molecular bromine to give PEG embedded potassium tribromide as a dark viscous oil. The synthesized material was found to be an efficient, cost effective, environmentally benign and ...
12
The Synthesis and Biological Examination of 5-Membered Nitrogen-Based Heterocycles.
... Within the last two decades there has been a large amount of research devoted to Gram negative bacteria, identifying quorum sensing circuits for over 25 species of bacteria. W[r] ...
262