NK cell cytotoxicity
Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control
... all NK cell functions were affected by 2DG, with intact IFN-γ production in vitro (10) and in vivo, and proliferation in ...allow NK cells to proliferate despite glycolytic ...for NK ...
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Role of gamma-secretase in human umbilical-cord derived mesenchymal stem cell mediated suppression of NK cell cytotoxicity
... than NK-MSC cm (Figure ...and NK cells came into contact, the soluble factor was released in lar- ger amounts and resulted in enhanced suppression as seen with NK-MSC ...reduced cytotoxicity ...
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Split anergized natural killer cells halt inflammation by inducing stem cell differentiation, resistance to NK cell cytotoxicity and prevention of cytokine and chemokine secretion
... anergized NK cells were long or short ...increased cell growth and restoration of NK cell cytotoxicity and cytokine secretion in cultures of NK cells with differentiated OSCSCs ...
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Human immunodeficiency causing mutation defines CD16 in spontaneous NK cell cytotoxicity
... on NK cells, FcγRIIIA (CD16), has been extensively studied for its role in mediating antibody- dependent cellular cytotoxicity ...patient’s NK cells to those of the originally reported ...spontaneous ...
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Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells
... NK cell–mediated cytotoxicity is limited by ...affects NK cells, we exposed murine NK cells to different doses of recombinant human ...of NK cells in a dose-dependent manner ...
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Expression of the Pseudorabies Virus gB Glycoprotein Triggers NK Cell Cytotoxicity and Increases Binding of the Activating NK Cell Receptor PILRβ
... Porcine NK cells express PILR  ...host cell membranes, including the plasma membrane (15), where it may interact with receptors expressed on other cells, including immune ...trigger NK ...
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The human 2B4 and NTB-A receptors bind the influenza viral hemagglutinin and co-stimulate NK cell cytotoxicity
... by NK cells is mediated by a balance between inhibitory and activating signals derived from inhibitory and activating ...by NK cells or spared ...the NK inhibitory receptors to MHC class I proteins ...
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Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F
... of NK cells with primary oral tumor cells was studied after treatment with IL-2 and/or anti CD16 antibody with and without ...primary NK cells were cytotoxic to oral tumor stem cells whereas anti-CD16 ...
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PHARMACOLOGICAL POTENTIAL OF BOERHAAVIA DIFFUSA: AN OVERVIEW
... (NK) cell cytotoxicity, production of nitric oxide (NO) in mouse macrophage cells, RAW ...various cell surface markers on human peripheral blood mononuclear cells ...human NK ...
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... to NK cell cytotoxicity are affected by the advancement of sialylation status of cancer ...of NK cell when combined with other specific ...siglec-7(+) NK cell shows more ...
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Deficient natural killer cell cytotoxicity in patients with IKK γ/NEMO mutations
... on NK cell cytotoxicity in patients with NEMO mutations. NK cell cytotoxic activ- ity is known to be enhanced by a variety of ...induce NK activity in vitro and upon ...
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Journal of Applied Pharmaceutical Science
... T cell mitogen (phytohemagglutinin; PHA) stimulated proliferation of human peripheral blood mononuclear cell (PBMC), mixed lymphocyte culture, lipopolysaccharide (LPS) stimulated nitric oxide production by ...
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Elevated Levels of Serum Vascular Endothelial Growth Factor-A Are Not Related to NK Cell Parameters in Recurrent IVF Failure
... terestingly, the levels of both factors were signifi- cantly higher in women who subsequently miscar- ried. This is in contrast to the reduced levels of serum sFLT reported by Muttukrishna et al. (41) in women with ...
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A systematic review of natural killer cells profile and cytotoxic function in myalgic encephalomyelitis/chronic fatigue syndrome
... in NK cell cyto- toxicity in ME/CFS patients compared with non-ME/ CFS fatigued controls ...reduced NK cell cytotoxicity is a useful indicator of immune dysfunction in ME/CFS ...of ...
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Natural killer cells in human autoimmune disorders
... However, NK cell defects have been identifi ed in treatment-naïve patients before overt progression to disease or at the time of diagnosis, demonstrating that the defects are not solely treatment related or ...
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Oncogenes in immune cells as potential therapeutic targets
... mouse NK cells that rec- ognizes a diverse family of ...of NK cells against cells expressing these ...of NK cell-activating ligands in cancer cells, making them targets of NK ...
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Icaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma
... Icaritin in DMSO (Sigma, Louis, MO, USA) and stored at −20°C. The final concentration of DMSO in the treat- ment medium was controlled below 0.1%. GCV was pur- chased from Hubei Ke Yi Pharmaceutic Co., Ltd (Hubei, ...
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Original Article Yupingfeng formula inhibits lung cancer metastasis via modulating NK cells in a mouse model
... of NK cells and T-cells were explored by flow cytometric ...test cytotoxicity and degranulation of NK cells and ...deplete NK cells through intraperi- toneal injections ...enhancing NK ...
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Specificity of human natural killer cells in limiting dilution culture for determinants of herpes simplex virus type 1 glycoproteins.
... To examine whether T-cell-depleted effector cells grown in LD culture showed cytotoxicity characteristic of NK cells, LD cultures were also tested against K562 target cells, the cell lin[r] ...
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RB mutation and RAS overexpression induce resistance to NK cell-mediated cytotoxicity in glioma cells
... células NK, y su susceptibilidad a la citotoxicidad mediada por células ...células NK, lo que se sugiere que los cambios específicos en un supresor de tumores (Rb) y un proto-oncogén (Ras) son suficientes ...
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