NK cell mediated cytotoxicity
RB mutation and RAS overexpression induce resistance to NK cell-mediated cytotoxicity in glioma cells
... to NK cell-mediated cytotoxicity, after the onset of malignant transformation and there- fore after immunoediting had likely already taken place [5, ...to NK cell-mediated ...
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Inhibition of NK cell-mediated Cytotoxicity by Tubular Epithelial Cell Expression of Clr Proteins
... B cell depleting antibodies, calcineurin inhibitors (CNI) such as tacrolimus, anti-proliferative agents such as azathioprine, mTOR inhibitors such as sirolimus, and glucocorticoids are used in various combinations ...
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Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells
... NK cell–mediated cytotoxicity is limited by ...affects NK cells, we exposed murine NK cells to different doses of recombinant human ...of NK cells in a dose-dependent ...
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Regulation of NK cell-mediated tubular epithelial cell death and kidney ischemia-reperfusion injury by the NKR-P1B receptor and Clr-b
... stimulate NK cell activity 109, 118, 156, 217 ...prevents NK cells from attacking “self-MHC” class I- expressing cells, whereas activating receptors such as natural-killer group 2 member D (NKG2D) ...
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Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F
... of NK cell cytotoxicity have been identified, including the over-expression of Fas-ligand, and down- regulation of granzyme B [9] and CD16 receptor and its associated zeta chain ...of NK ...
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Expression of the Pseudorabies Virus gB Glycoprotein Triggers NK Cell Cytotoxicity and Increases Binding of the Activating NK Cell Receptor PILRβ
... cells. NK cells are particularly important in the innate defense against herpesviruses, including alpha- ...with NK cell deficiencies. NK cells are regulated by a diver- sity of activating and ...
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Epithelial mesenchymal transition leads to NK cell–mediated metastasis specific immunosurveillance in lung cancer
... to NK cytotoxic- ity through KLRG1. Classically, inhibitory signals on NK cells are mediated by receptors that recognize MHC I ...that NK cells also express other recep- tors like KLRG1 that ...
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Split anergized natural killer cells halt inflammation by inducing stem cell differentiation, resistance to NK cell cytotoxicity and prevention of cytokine and chemokine secretion
... anergized NK cells, we determined NK cell mediated cytotoxicity when OSCSCs were treated with supernatants of NK cells treated with anti-CD16mAb and IL-2 in the presence and ...
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Role of gamma-secretase in human umbilical-cord derived mesenchymal stem cell mediated suppression of NK cell cytotoxicity
... than NK-MSC cm (Figure ...and NK cells came into contact, the soluble factor was released in lar- ger amounts and resulted in enhanced suppression as seen with NK-MSC ...reduced cytotoxicity ...
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HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody- dependent cell-mediated cytotoxicity
... different NK cell receptors ...tumor cell lysis and no significant improvements were obtained when B7- H6:HER2-scFv was combined with ...triggering NK cell cytotoxicity and are ...
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Matrix Metalloprotease Inhibitors Restore Impaired NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Human Immunodeficiency Virus Type 1 Infection
... that NK cells not only are critical in the initial host defense against pathogens but also may contribute to continued protection from human immunodeficiency virus type 1 (HIV-1) disease ...progression. NK ...
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Role for TLR2 in NK Cell-Mediated Control of Murine Cytomegalovirus In Vivo
... of NK cells in response to MCMV infection are regulated by complex ...activate NK cells in response to the ...activating NK receptor Ly49H (4, 43), and this interaction contributes to the induction ...
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Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma
... from Cell Signaling (DNA Damage Anti- body Sampler Kit #9947) has been used, as already de- scribed in previous work by us and others ...block cell cycle progression (through, for example, ...
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Human immunodeficiency causing mutation defines CD16 in spontaneous NK cell cytotoxicity
... other NK cell receptors of the Ig ...is mediated by a direct physical interaction through the distal Ig-like domain of CD16, or whether the distal domain is involved in an interaction with anoth- er ...
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... normal cell, as these cells do not possess antigen-specific receptors. NK cells and cytotoxic T-cells work in a complementary manner to produce an immune response directed against viruses and tumour ...then ...
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Elevated Levels of Serum Vascular Endothelial Growth Factor-A Are Not Related to NK Cell Parameters in Recurrent IVF Failure
... terestingly, the levels of both factors were signifi- cantly higher in women who subsequently miscar- ried. This is in contrast to the reduced levels of serum sFLT reported by Muttukrishna et al. (41) in women with ...
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Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control
... cells/kg), and the donor was his healthy brother (CMV seronegative). Graft-versus-host disease (GVHD) prophylaxis was with cyclosporine and mycophenolate mofetil, and viral prophylaxis was with high-dose acyclovir (800 ...
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NK1 1 receptor ligation or tumour interactions prime NK cells for IL2 mediated metabolic and functional responses
... of NK cells. However, strikingly NK1.1 mediated activation of NK cells results in robust CD25 ...that NK cells have mechanisms that would allow them to function alongside the adaptive immune ...
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Immunosuppressive therapy with rituximab in common variable immunodeficiency
... Even though the major part of RTX-immunomodula- tory effects are accountable to B-cell depletion, evidence has proved that RTX also may target both helper and cytotoxic T-cells. The effect of RTX on T-cell ...
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Jordan, Stefan (2011): Modulation of extramedullary hematopoiesis during cytomegalovirus infection. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... reconstitution, NK cells in these mice express the human diphtheria toxin receptor (DTR) and can be selectively depleted by injection of diphtheria toxin ...Nevertheless, NK cell depletion by ...
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