NKG2D ligand
Varicella-Zoster Virus and Herpes Simplex Virus 1 Differentially Modulate NKG2D Ligand Expression during Productive Infection
... regulates NKG2D ligand ...in NKG2D ligand or MHC-I expression (less respective isotypes) is presented below each correlating histogram as the mean ⫾ SEM of data from biological replicates ...
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Selective Down-Regulation of the NKG2D Ligand H60 by Mouse Cytomegalovirus m155 Glycoprotein
... NKG2D ligand expression is restricted in normal cells and tissues to avoid becoming a target for NK ...the NKG2D receptor is also expressed on T cells and macrophages, it is also possible that ...
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Xanthine oxidoreductase is required for genotoxic stress- induced NKG2D ligand expression and gemcitabine-mediated antitumor activity
... uric acid induces nKG2d ligand expression We next tested whether exogenous uric acid was able to induce MICA/B expression. Due to its acidity and poor solubility [40], uric acid was used in its sodium form, ...
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Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype
... of NKG2D immunity and development of effective therapy to restore endogenous anti-tumor ...soluble NKG2D ligand, sMIC, not only down-modulates NKG2D expression on NK cells but also perturbs NK ...
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NKG2D Ligand MICA Is Retained in the cis-Golgi Apparatus by Human Cytomegalovirus Protein UL142
... receptor NKG2D (6, 19, 21, ...with NKG2D ligand surface ex- pression would provide HCMV with a long window of oppor- tunity to replicate and spread to further individuals following reactivation from ...
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Crystal Structure of the Cowpox Virus-Encoded NKG2D Ligand OMCP
... The NKG2D receptor is expressed on the surface of NK, T, and macrophage lineage cells and plays an important role in antiviral and antitumor ...evade NKG2D recognition, herpesviruses block the expression of ...
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Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay
... the NKG2D ligand MICA in different MM cell lines, with no significant effects on MICB and PVR/CD155 ...other NKG2D and DNAM-1/ CD226 ligands, SKO-007(J3) cells express low or undetect- able levels of ...
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Immunoassays for scarce tumour-antigens in exosomes: detection of the human NKG2D-Ligand, MICA, in tetraspanin-containing nanovesicles from melanoma
... that NKG2D-ligands are found in high levels in the serum of different types of cancer patients, and the ultimate goal of developing new tools for detection of MICA in exosomes is the analysis of bio- logical ...
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Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy
... human NKG2D ligands, MICA and MICB are the most frequently and broadly expressed ligands on human solid tumors ...the NKG2D immunity by releasing the soluble form of MIC (sMIC), through the process of ...
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Human U87 glioblastoma cells with stemness features display enhanced sensitivity to natural killer cell cytotoxicity through altered expression of NKG2D ligand
... study, NKG2D–NKG2DL interaction played a significant role in enhanced NK cytotoxic- ity against glioma cell ...downregulate NKG2D expression on NK cells through transforming growth factor-beta-dependent ...
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Downregulation of the stress-induced ligand ULBP1 following SV40 infection confers viral evasion from NK cell cytotoxicity
... the NKG2D ligand expression we initially searched for a human model cell line; A cell line which supports the SV40 life cycle and is also known to endogenously express several NK ...
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Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD like disease
... of NKG2D ligand induction on pulmonary cells, we presume that it is likely a combination of direct effects of the many toxicants present in cigarette smoke and the indirect effects of products of tissue ...
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The NKG2D – IL-15 signaling pathway contributes to T-cell mediated pathology in inflammatory myopathies
... soluble NKG2D ligand MICA assessed by ELISA in serum of HD and PM patients (n = ...express NKG2D (HRP-DAB staining and counterstaining with haemalum; NKG2D + (immunofluorescence: red) cells ...
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Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties
... high-affinity NKG2D ligand RAE-1γ ...the ligand for an activating NK cell receptor could be a powerful approach to developing a safe and immunogenic HCMV ...
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Impaired Downregulation of NKG2D Ligands by Nef Proteins from Elite Controllers Sensitizes HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity
... of NKG2D ligands on the surface of infected cells ...that NKG2D contributes to HIV-1 disease ...of NKG2D (30). The role of Nef in decreasing NKG2D ligand expression on infected cells is ...
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Lack of MICA Expression Predicts a Worse Prognosis in Patients with Bladder Cancer
... implicate NKG2D receptor acti- vation as a mechanistic link between epithelial cell stress and lymphocyte activation in epithelial ...tissues. NKG2D ligand expression is generally absent from healthy ...
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... An important component of the innate immune system, the natural killer cells that originate from the lymphoid cell lineage, hold tremendous potential as an effective therapeutic tool to combat a variety of cancers. Their ...
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Bispecific NKG2D-CD3 and NKG2D-CD16 fusion proteins for induction of NK and T cell reactivity against acute myeloid leukemia
... targets. NKG2D-Fc-ADCC was not in- cluded in these analyses, as the previous experiments had already confirmed superior efficacy of NKG2D- ...that NKG2D-CD16 and NKG2D-CD3 potently stimulated ...
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Abnormal expression levels of sMICA and NKG2D are correlated with poor prognosis in pancreatic cancer
... and NKG2D in pancreatic carcinoma tissue and paracarcinoma tissue by ...and NKG2D expression was downregulated in pancreatic carcinoma tissues: that is, sMICA expression was negatively correlated with ...
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Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells
... Agents that cause genotoxic stress or DNA- replication inhibitors have been recently shown to activate the DNA damage response (DDR) as well as to increase the expression of stress-induced NKG2D and DNAX accessory ...
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