NM23-H1
EBNA3C Can Modulate the Activities of the Transcription Factor Necdin in Association with Metastasis Suppressor Protein Nm23-H1
... whereas Nm23-H1 NDP kinase activity is important for providing NTPs for nucleic acid synthesis and hence promotes cell ...of Nm23-H1 is also responsible for biosynthesis of GTPs, which are ...
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Targeting NM23-H1-mediated Inhibition of Tumour Metastasis in Viral Hepatitis with Bioactive Compounds from Ganoderma lucidum: A Computational Study
... the NM23-H1 and to enhance its tumour suppression and metastasis in various forms of cancers especially in HCV-associated tumours has not been ...proteins, NM23-H1 was retrieved from the PDB ...
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Epstein-Barr Virus Protein Can Upregulate Cyclo-Oxygenase-2 Expression through Association with the Suppressor of Metastasis Nm23-H1
... of Nm23-H1 is surprising, considering that Nm23-H1 is known to be ...of Nm23-H1 in B cells is in the cytoplasm ...of Nm23-H1 from cytoplasm to nucleus appears to be ...
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Regulation of Matrix Metalloproteinase 9 Expression by Epstein-Barr Virus Nuclear Antigen 3C and the Suppressor of Metastasis Nm23-H1
... suppressor Nm23-H1 was found to bind to a short stretch of amino acids located between the glutamine- and proline-rich domains of EBNA3C (36, ...between Nm23-H1 and EBNA3C has been shown to ...
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The Metastatic Suppressor Nm23-H1 Interacts with EBNA3C at Sequences Located between the Glutamine- and Proline-Rich Domains and Can Cooperate in Activation of Transcription
... allow Nm23-H1 to direct a broad spectrum of phenotypic changes through multiple target ...of Nm23-H1 and the effect of EBNA3C on any observed tran- scriptional activity, because this might ...
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Nm23-H1 suppresses hepatocarcinoma cell adhesion and migration on fibronectin by modulating glycosylation of integrin beta1
... in Nm23/H7721 cells, while the α5 integrin was ...by nm23-H1 might be partially due to the lower expression of β1 ...DR- nm23 isoform in neuroblastoma cells, and this was correlated with an ...
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Regulation of Nm23-H1 and Cell Invasiveness by Kaposi's Sarcoma-Associated Herpesvirus
... of Nm23-H1 suppressed cell invasiveness induced by KSHV infection or LANA ...of Nm23-H1 suppresses Ras- BRaf-MAPK pathway activation and secretion of VEGF and IL-8 by KSHV-infected ...
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Epstein-Barr Virus Nuclear Antigen 1 Interacts with Nm23-H1 in Lymphoblastoid Cell Lines and Inhibits Its Ability To Suppress Cell Migration
... The nm23 gene family is highly conserved among a wide variety of eukaryotic ...humans: nm23-H1 (40), nm23-H2 (44), DR-nm23 (53), nm23- H4 (29), nm23-H5 (30), ...
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17beta hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration
... that expresses both estrogen and androgen receptors. Since the cell line barely expresses endogenous 17b- HSD1 [11,15], we used it as cell model for the increase of 17 b -HSD1 expression. The proteomic approach using ...
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High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N myc gene amplification
... designated nm23-H1, which was recently identified as identical to the A subunit of nucleotide diphosphate kinase from human erythrocytes, has been proposed to play a role in tumor metastasis ...
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Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1
... to NM23 proteins. The NM23 family consists of nucleotide diphosphate kinases (NDPKs), which exchange -phosphate between nucleotide triphos- phate and diphosphate ...activity, NM23-H1 and -H2 ...
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Proteomics of AML1/ETO Target Proteins: AML1–ETO Targets a C/EBP–NM23 Pathway
... AML1–ETO is stably transfected in U937 cells under Zn- inducible metallothionein promoter (U937Z/A-E) or under the tet-off-inducible promoter (U937T/A-E) [19, 27]. AML1–ETO protein expression is induced when Zn is added ...
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Proliferation related expression of p19/nm23 nucleoside diphosphate kinase
... the nm23-H1 gene, which encodes for a nucleoside diphosphate kinase, has been found to correlate with diminished metastasis in some tumors but not in ...the nm23-H1 gene in two- dimensional ...
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Expression of nm23 in the spectrum of pre-invasive, invasive and metastatic breast lesions
... and nm23 RNA protein was found in four different metastatic models. Nm23 gene has been localized at chromosome 17q21 and two isoforms (nm23-H1 and nm23-H2) have been ...of nm23 ...
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Original Article Ki67 and nm23 are potential prognostic markers in patients with nasopharyngeal carcinoma
... The nm23 gene has been proposed as a metas- tasis suppressor gene ...genes, nm23-H1 and nm23-H2, which encode the A and B subunits of nucleo- side diphosphate kinase ...of nm23 was ...
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Alcohol promotes breast cancer cell invasion by regulating the Nm23-ITGA5 pathway
... The Nm23 siRNA, ITGA5 siRNA, and negative controls were pur- chased from Invitrogen (Carlsbad, CA, ...pcDNA3- Nm23-H1 cDNA and the control vector were kindly provided by ...
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Molecular biology of breast cancer metastasis Genetic regulation of human breast carcinoma metastasis
... gene, Nm23, was identified in the murine K1735 melanoma using subtrac- tive hybridization, because its expression was inversely correlated with lung ...homolog Nm23-H1 (also known as NME1) is ...
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Dissecting the contribution of EBNA3C domains important for EBV- induced B-cell growth and proliferation
... The Nm23-H1 protein is a known suppressor of cell migration, tumor metastasis and it is expressed in all ...cellular Nm23-H1 is associated with decreased metastasis in breast cancer, melanoma, ...
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Clinical and immunohistochemical study of eight cases with thymic carcinoma
... EMA, nm23-H1, VEGF and FGF-2 were predominantly observed in the cy- toplasm of the tumor cells ...EMA, nm23-H1, VEGF and FGF-2 was detected in 5/8 ...
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Original Article The associations of biological parameters with the effects of radiotherapy and cisplatin-based concurrent chemoradiotherapy in uterine cervical cancer
... Almost all cervical cancer patients with para- metrial invasion, inadequate surgical vaginal margin or regional lymph node metastasis received radiotherapy or CCRT. Thus, these variables were not included in the analyses ...
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