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NMDA Receptors

Agonists of CB1 and NMDA receptors decrease the toxic effect of organophosphorus compound paraoxon on PC12 cells

Agonists of CB1 and NMDA receptors decrease the toxic effect of organophosphorus compound paraoxon on PC12 cells

... of NMDA recep- tors. Several evidences revealed that blockade of NMDA receptor activity leads to a widespread apo- ptosis and neurodegeneration in the adult ...of NMDA receptors for a few ...

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NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

... How neuronal proteomes self-organize is poorly understood because of their inherent molecular and cellular complexity. Here, focusing on mammalian synapses we use blue-native PAGE and ‘gene-tagging’ of GluN1 to report ...

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NMDA receptors are important regulators of pancreatic cancer and are potential targets for treatment

NMDA receptors are important regulators of pancreatic cancer and are potential targets for treatment

... (NMDA) receptors as surface components. These receptors are ion-channels that are concentrated within the brain with limited peripheral expression and comprise protein ...

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mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway

mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway

... (NMDA) receptors based on agonist preference. Metabotropic glutamate receptors (mGluRs) are members of G-protein-coupled receptor (GPCR) and influence a variety of intracellular second messenger ...

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Biochemical and pharmacological characterisation of the interaction between nMDA receptors and the scaffolding protein, PSD-95

Biochemical and pharmacological characterisation of the interaction between nMDA receptors and the scaffolding protein, PSD-95

... of NMDA receptor-mediated changes in synaptic transmission are the long term changes in the efficiency of transmission at glutamatergic synapses following either low-frequency or high frequency stimulation of ...

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"Smart fats", healthy brain and function of lipid sensing NMDA receptors

"Smart fats", healthy brain and function of lipid sensing NMDA receptors

... of NMDA re- ceptors ...mutant NMDA receptors in po- sition 598 of the NR1 subunit developed dysfunction in the nervous system with phenotypes ranging from re- duced life expectancy, growth ...

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NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment

NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment

... that NMDA receptors are present on SCLC and are likely agents for maintaining cell growth and ...these receptors on most SCLC has yet to be substantiated by examining a much larger number of ...NMDAR ...

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Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

... glutamate receptors might contribute to the inward current activated in the astrocytes by stimulation of synaptic ...astrocytic NMDA receptors, we perfused cortical astrocytes with 10 µM MK801 ...

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Properties of NMDA receptors in identified cerebellar cell types

Properties of NMDA receptors in identified cerebellar cell types

... of NMDA receptor (Momiyama et ...native NMDA receptor single-channel activity can be divided into discrete high-conductance (NR2B- or NR2A-containing) and low-conductance (NR2C- or NR2D-containing) ...

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Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo

Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo

... facilitatory role of mGlu5Rs in NMDAR-dependent LTD induction is consistent with the interpretation that significant co-activation of mGlu5Rs and NMDARs at non-synaptic sites is involved. The likelihood of this occur- ...

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NMDA receptors are expressed in human ovarian cancer tissues and human ovarian cancer cell lines

NMDA receptors are expressed in human ovarian cancer tissues and human ovarian cancer cell lines

... functional NMDA receptors that can be targeted to promote cancer cell ...express NMDA-receptor subunit 1 (GluN1) and subunit 2B ...the NMDA-receptor antibodies, while no staining was found for ...

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The importance of N methyl d aspartate (NMDA) receptors in subtraction of electrosensory reafference in the dorsal nucleus of skates

The importance of N methyl d aspartate (NMDA) receptors in subtraction of electrosensory reafference in the dorsal nucleus of skates

... postsynaptic NMDA receptors on the principal ...of NMDA receptors from a South American electric ...the NMDA receptor antagonists 2-amino-5-phosphonovaleric acid (APV) or MK801 is ...

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The participation of NMDA receptors, PKC, and MAPK in the formation of memory following operant conditioning in Lymnaea

The participation of NMDA receptors, PKC, and MAPK in the formation of memory following operant conditioning in Lymnaea

... an NMDA receptor blocker, and inhibitors of the intracellular cascades involving PKC, and MAPK respectively are able to block the for- mation of both ITM and ...(i.e. NMDA receptors, PKC, and MAPK) ...

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Characterisation of the binding of two novel glycine site antagonists to cloned NMDA receptors

Characterisation of the binding of two novel glycine site antagonists to cloned NMDA receptors

... the NMDA-induced excitation o f rat and cat spinal neurons (Anis et al, ...block NMDA- induced currents in a use- and voltage-dependent manner (Holney et al, ...of NMDA receptors (Monaghan and ...

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8-23-2012 12:00 AM The cross talk between TrkB and NMDA receptors through RasGrf1

8-23-2012 12:00 AM The cross talk between TrkB and NMDA receptors through RasGrf1

... Trk receptors have also been shown to co-ordinate and co-operate with other receptors including G protein-coupled receptors (GPCR) (Weise et ...AMPA receptors (Wu et al., 2004; Caldeira et ...

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Concise review on role of nmda receptors in alzheimer’s disease

Concise review on role of nmda receptors in alzheimer’s disease

... the NMDA receptors (NMDARs) and thru activation of the phosphoinositide communication pathway that generates Btrisphosphate (InsP3) that releases Ca2+ from the interior ...M1 receptors that drive ...

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Identification of a single amino acid in GluN1 that is critical for glycine-primed internalization of NMDA receptors

Identification of a single amino acid in GluN1 that is critical for glycine-primed internalization of NMDA receptors

... tamate receptors is believed to lead to a partially closed state of the S1S2 which is unable to couple to gating ...AMPA receptors where antagonists as well as agonists cause receptor in- ternalization ...

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Experience-dependent regulation of presynaptic NMDA receptors (preNMDARs) and their role in neurotransmission and synaptic plasticity

Experience-dependent regulation of presynaptic NMDA receptors (preNMDARs) and their role in neurotransmission and synaptic plasticity

... presynaptic terminal to express LTD. While acute blockade of preNMDARs during post-pre spike pairing does not block tLTD at this synapse, persistent blockade of preNMDARs for many minutes prior to pairing does block tLTD ...

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Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors

... with NMDA (1 mM) and glycine (100 μM) (defined as high NMDA/glycine in this article) for 10 min or with DHPG (50 μM) for 5 min were determined with bio- chemical assays and imaging ...high ...

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Investigating the influence of PFC transection and nicotine on dynamics of AMPA and NMDA receptors of VTA dopaminergic neurons

Investigating the influence of PFC transection and nicotine on dynamics of AMPA and NMDA receptors of VTA dopaminergic neurons

... and NMDA curves represent the whole GluR response with respect to ...and NMDA signals since they took into consideration the whole current response rather than just the peak ...

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