NMDA Receptors: History, Form and Function
Between form and function: history and identity in the blogosphere
... a history of the blog provides evidence of a direct lineage connecting the pioneering producer-‐users at ARPA to the makers of the earliest ...Turner’s history of the WELL, another function of the ...
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Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo
... these receptors in NMDA receptor-dependent synaptic plasticity in the adult hippocampus in ...into NMDA receptor (NMDAR) and metabotropic glutamate receptor (mGluR) –dependent ...this form of ...
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NMDA RECEPTORS, PLACE CELLS AND HIPPOCAMPAL SPATIAL MEMORY
... learning on a STEP-DOWN INHIBITORY AVOIDANCE TASK in rats that have received an intrahippocampal infusion of AP5 (REF. 48) . The NMDAR dispensability that is induced by pretraining seems to reflect the complexity of the ...
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GPR40 modulates epileptic seizure and NMDA receptor function
... consent form was signed by the patients or their lineal ...elaborate history and neurological examination, electroencephalo- gram studies, neuropsychological testing, and neuroimaging ...
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Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits
... channel receptors have three transmembrane domains (TMs) and terminate with intracellular tails that are important for controlling channel expression and ...of NMDA receptor subunits before the final TM ...
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"Smart fats", healthy brain and function of lipid sensing NMDA receptors
... different NMDA re- ceptor subunits could aid in developing novel lipophilic therapeutic agents and nutritional strategies for better treatment and prevention of these important medical ...
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Supramolecular organization of NMDA receptors and the postsynaptic density
... Anatomical diversity of synapses There are two aspects of synapse complexity. First, it is clear that a single synapse contains possibly hundreds of different proteins assembled within multiple molecular machines ...
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Concise review on role of nmda receptors in alzheimer’s disease
... precursor (APP) to form the amyloid β aggregation-prone product that accumulates in the brain in Alzheimer's disease. As evidence suggests that Aβ is criti Alzheimer pathogenesis, γ-secretase is considered a key ...
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The Role of NMDA Receptors in Extinction of Cocaine Self-Administration
... which NMDA receptors mediate extinction: Future directions Despite our currently conflicting effect with CPP post-extinction injections, previous research and our other findings suggest NMDA ...
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Targeting NMDA receptors in stroke: new hope in neuroprotection
... Concluding remarks and future directions NMDARs are essential in supporting neuronal functions under physiological functions, and also play a central role in excitotoxicity that causes neuronal death after is- chemic ...
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Properties of NMDA receptors in identified cerebellar cell types
... To obtain further information about the transitions between the main- and sub conductance states, single-channel currents from some Golgi cell patches were analysed with time-course fitting. An amplitude histogram, ...
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NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation
... support the PDZ-ligand-dependent assembly of NMDARs with Dlg/MAGUK proteins, the reduced overall levels of NMDAR expression in mice lacking GluN2A/B PDZ-ligands indicates the importance of this interaction in the ...
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Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction
... NMDAR function, we will describe just a few promising findings regarding the effects of CBD on schizophrenia, and the effects of CBD combined with cannabinoids in the treatment of NMDAR convulsive ...
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NMDA receptors are important regulators of pancreatic cancer and are potential targets for treatment
... cancer, NMDA receptors, inhibitors, potential therapy Introduction Pancreatic cancer is the fourth leading cause of death from cancer throughout the world, and accounts for the loss of ~ 40,000 persons in ...
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Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance
... between NMDA receptors and the effects of morphine has been thoroughly investigated, fewer studies examine changes in NMDA receptor medi- ated responses after prolonged morphine ...enhanced ...
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The NMDA Receptor Transmembrane Region in Receptor Function and Inhibition
... uncharged form of memantine is >1000-fold more soluble in octanol than water. This suggests that uncharged memantine resides preferentially in the membrane, and is consistent with data indicating that the ...
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Reconsolidation of appetitive instrumental memory and the metaplastic effects of NMDA receptors blockade in rats
... 2 Abstract Obesity is one of the leading cause of death in world’s population, due to the comorbidity with pathologies like cardiovascular or mental disorders. Deviating from its role as a primary need, obese and ...
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Characterisation of the binding of two novel glycine site antagonists to cloned NMDA receptors
... whether NMDA receptor antagonism is the predominant mechanism for ...of NMDA receptor ...kainate receptors in glutamate-induced excitotoxicity could be potentially predicted (McDonald, ...
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Contribution of NMDA and AMPA Receptors to Temporal Patterning of Auditory Responses in the Inferior Colliculus
... Although NMDA receptors (NMDARs) are associated with synaptic plasticity, they form an essential part of responses to sensory ...AMPA receptors (AMPARs) to auditory responses in the inferior ...
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BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A
... extrasynaptic NMDA receptor signaling and reduced expression of activity- and calcium- signal-regulated genes critical, for example, for the stabilization and strengthening of mitochondrial functions (Lau and ...
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