Nociceptive Neurons
Suppression of hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia following systemic administration of lutein via inhibition of cyclooxygenase-2 cascade signaling
... trigeminal nociceptive inputs following inflammation and tissue injury ...SpVc nociceptive neurons are classified as nociceptive- specific (NS) and wide-dynamic range (WDR) based on their ...
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SDF1–CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation
... nociceptor neurons can be ...primary nociceptive neurons ...DRG neurons under several persistent pain conditions ...depolarize nociceptive DRG neurons in cultured DRG ...
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Nociceptive neurons detect cytokines in arthritis
... sensory neurons the concept begins to emerge that different cytokines are involved in particular qualities of pain, such as mecha- nical or thermal hyperalgesia (Figure ...
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Runx transcription factors in neuronal development
... of nociceptive neurons ...trkA-expressing neurons dif- ferentiate into two subpopulations of nociceptive neu- rons; trkA-retaining peptidergic neurons, and non- peptidergic ...
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Comparison of the transport of QX-314 through TRPA1, TRPM8, and TRPV1 channels
... into nociceptive neurons, through the pores of transient receptor potential ankyrin 1 (TRPA1), transient receptor potential melastatin-8 (TRPM8), and ...
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THE ROLE OF THE THALAMUS IN MODULATING PAIN
... VPL nociceptive neurons have restricted receptive fields and precisely encode the intensity of noxious stimuli (32, 41) and these characteristics are consistent with the functions of lateral pain ...The ...
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The G Protein regulators EGL-10 and EAT-16, the Giα GOA-1 and the Gqα EGL-30 modulate the response of the C. elegansASH polymodal nociceptive sensory neurons to repellents
... mammalian nociceptive neurons of the dorsal root ganglia, the ...sensory neurons detect stimuli of different nature (polymodality), use a TRPV channel as the main signal transduction channel and ...
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The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M type K+ channels and activation of Ca2+ activated Cl– channels
... small nociceptive neurons from rat dorsal root ganglia, BK, acting through its B 2 receptors, PLC, and release of calcium from intracellular stores, robustly inhibits M-type K + channels and opens Ca 2+ ...
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Interleukin 6 dependent influence of nociceptive sensory neurons on antigen induced arthritis
... on nociceptive neurons and is therefore regarded as a putative pain mediator ...(DRG) neurons, the cell bodies of sensory neurons, express the signal transducer gp130 [11, 12], and gp130 ...
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Fine grained nociceptive maps in primary somatosensory cortex
... poor nociceptive innervation density on the digits (Arthur and Shelley, 1959; Kelly et ...fine nociceptive spatial resolution we have observed in SI might result from complex interactions between tactile ...
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Decanoic acid attenuates the excitability of nociceptive trigeminal primary and secondary neurons associated with hypoalgesia
... Notes: When noxious mechanical stimulation is applied to the skin, mechanosensitive ion channels open (eg, TRP channel family, such as TRPA1), activating the generator potential (depolarization). This depolarization ...
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Intense isolectin B4 binding in rat dorsal root ganglion neurons distinguishes c fiber nociceptors with broad action potentials and high nav1 9 expression
... ⫺ neurons being small, medium, and large sized ...small neurons were IB4⫹ (intensity ⱖ20%); indeed 81% (597 of 741) were strongly IB4⫹ (intensity ...⫹ neurons closely mimics that of the “small dark” ...
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Characterization of ectonucleotidases in nociceptive circuits
... DRG neurons primarily express the transmembrane isoform of PAP (Zylka et ...nonpeptidergic nociceptive neurons, a subset of peptidergic nociceptive neurons and to axon terminals located ...
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Influences of smoking and caffeine consumption on trigeminal pain processing
... The influence of caffeine and nicotine on pain process- ing is well described in the literature. Various analgesic as well as nociceptive properties of both substances were reported, previously. Smoking and ...
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The effect of nerve injury on the spinal and peripheral actions of galanin and interleukin-6 on sensory processing
... Other than the role o f IL-6 in nociception (1.7.6), there is evidence that IL-6 has a role in neuronal survival, neuroprotection and neuronal differentiation. In vitro IL-6 has been shown to enhance the survival o f ...
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M‐type K⁺ channels in peripheral nociceptive pathways
... When peripheral axons are severed (e.g. by trauma), the nerve stump forms a swelling or endbulb, which then sprouts thin processes, which may re-connect severed nerve endings, if these are in close enough proximity. If ...
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Square Neurons, Power Neurons, and Their Learning Algorithms
... square neurons and power neurons, which will improve all digits in Table ...square neurons simply square every number in Table 1, see Table ...
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Central effects of acetylsalicylic acid on trigeminal-nociceptive stimuli
... during nociceptive stimulation and known to play a crucial role in the processing of pain ...to nociceptive stimulation using an electroencephalogram ...
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INVESTIGATION OF ANALGESIC ACTIVITY OF AMARANTHUS SPINOSUS LINN. (LEAVES) FROM BANGLADESH IN SWISS ALBINO MICE
... The hot plate test and tail immersion model are used to evaluate the centrally acting analgesics 18 . In the hot plate test, the paw-licking or jumping responses in the hot plate are considered as a complex supraspinal ...
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Integrating osteopathic approaches based on biopsychosocial therapeutic mechanisms. Part 2: Clinical approach
... nociceptive driver is removed [72], addressing tissues in people with chronic pain, along with neurological and psychosocial factors, may still be justified. Movement impairment may initially relate to guarding ...
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