NOD/SCID
Previously undetected human hematopoietic cell populations with short term repopulating activity selectively engraft NOD/SCID β2 microglobulin–null mice
... the NOD/SCID RC (LTRC) frequencies reported for these different cell ...of NOD/SCID RCs in mPB CD34 + cells has been found to be ten- ...
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Human Interleukin-15 Improves Engraftment of Human T Cells in NOD-SCID Mice
... Human T cells isolated from IL-15-treated huPBL-NOD- SCID mice had normal function. In addition to the distribution and phenotype of engrafted huPBLs in rhIL-15-treated huPBL-NOD-SCID mice, ...
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Cooperative Effect of the Attenuation Determinants Derived from Poliovirus Sabin 1 Strain Is Essential for Attenuation of Enterovirus 71 in the NOD/SCID Mouse Infection Model
... a NOD/SCID mouse infection ...4-week-old NOD/SCID mice by adaptation of the virulent EV71(Nagoya) strain in the brains of NOD/SCID ...in NOD/SCID ...3-week-old ...
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Experimental Infection of NOD/SCID Mice Reconstituted with Human CD34+ Cells with Epstein-Barr Virus
... that NOD/SCID mice that are reconstituted with human CD34 ⫹ cells can be experimentally infected with EBV and that their infection results in the development of ...in NOD/SCID mice infected ...
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Expansion of human NOD/SCID repopulating cells by stem cell factor, Flk2/Flt3 ligand, thrombopoietin, IL 6, and soluble IL 6 receptor
... Here, we demonstrate a significant ex vivo expansion of human hematopoietic stem cells capable of repopulating in NOD/SCID mice. Using a combination of stem cell factor (SCF), Flk2/Flt3 ligand (FL), ...
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In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning
... for SCID-X1 appears to have resulted in leukemia due to insertion into the oncogene LMO-2 ...into NOD/SCID mice shows that, on average, three to five integrations occur per ...
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KSHV targets multiple leukocyte lineages during long term productive infection in NOD/SCID mice
... of NOD/SCID mice. NOD/SCID spleens were col- lected 1 month (A and B) and 4 months (C and D) after intravenous injection with PBS (A), KSHV (B and C), and UV-KSHV ...
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GAD reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice
... young NOD mice, and which respond to this epitope of GAD65, may well be important in the early initiating phases of ...in NOD/SCID mice without cotransferred CD8 T ...
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Alteration of intra pancreatic target organ specificity by abrogation of Aire in NOD mice
... Aire-deficient NOD mice with at least a similar frequency to that in Aire-sufficient NOD ...Aire-deficient NOD mice demonstrated resistance to the develop- ment of diabetes, both in their natural ...
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Stimulative role of ST6GALNAC1 in proliferation, migration and invasion of ovarian cancer stem cells via the Akt signaling pathway
... A total of 36 NOD-SCID mice were divided into si-NC group (NOD-SCID mice inoculated with OC stem cells with silent empty plasmid), si-ST6GAL- NAC1 (NOD-SCID mice inoculated with OCSCs [r] ...
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MLLT11/AF1q boosts oncogenic STAT3 activity through Src- PDGFR tyrosine kinase signaling
... RESULTS Enhancing AF1q expression activates STAT3 and promotes tumor growth and metastasis in immunodeficient Nod/Scid/Gamma chain null NSG mice We recently demonstrated the contribution[r] ...
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Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy
... ( A ) In vivo bioluminescent imaging and ( B ) overall survival of NOD scid γ (NSG) immunodeficient mice bearing estab- lished, systemic, NALM6-GL leukemia xenografts following adoptive[r] ...
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Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs
... of SCID mice based on the gender. Female SCID mice were more effective in supporting engraft- ment of foreign cells compared to their male counter- part [21, ...
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Critical Role for TSLC1 Expression in the Growth and Organ Infiltration of Adult T-Cell Leukemia Cells In Vivo
... The tumor suppressor lung cancer 1 gene (TSLC1) at chromosome 11q23 has been identified as a tumor suppres- sor gene in non-small-cell lung cancer (9, 13). In contrast, it was recently found to be highly and ectopically ...
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Applying toponome imaging system for studying colon cancer
... Two scientific groups reported that colon cancer cells expressing CD133 were uniquely capable of initiating, proliferation and sustaining the tumour in NOD/SCID mice and therefore claime[r] ...
217
Recovery of a human natural antibody against the noncollagenous 1 domain of type IV collagen using humanized models
... Methods: NOD‑scid‑gamma immunodeficient mice were engrafted either with human CD34 + hematopoietic stem cells (HSC) (Hu‑HSC mice) and immunized with alpha3(IV)NC1 collagen containing the Goodpasture ...
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Experimental transmission of Babesia microti by Rhipicephalus haemaphysaloides
... and NOD/SCID mice were infested by nymphs molting from larvae that ingested the blood of infective mice, and blood samples were then analyzed by ...the NOD/SCID ...
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CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells
... of NOD/SCID mice, after approval from the Committee on the Ethics of Animal Experiments of the University of Campinas (permit number ...Prkdc scid /J (NOD/SCID) mice sub-lethally ...
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Passive transfer models of myasthenia gravis with muscle-specific kinase antibodies
... IgG1-3 fraction of the same MuSK MG patient did not induce any signs of in vivo disease and functional or histological NMJ aberrations in dissected muscles. A possible explanation for the lack of effect from IgG1-3 IgG ...
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Autocrine stimulation of VEGFR 2 activates human leukemic cell growth and migration
... (NOD- SCID) mice ...into NOD-SCID mice resulted in the engraftment and formation of leukemic foci in the bone marrow, spleen, liver, and peripheral circulation of NOD-SCID ...the ...
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