NOD–scid mice
GAD reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice
... tolerize mice and to prevent the onset of diabetes (12–14, ...young NOD mice, and which respond to this epitope of GAD65, may well be important in the early initiating phases of ...in ...
7
KSHV targets multiple leukocyte lineages during long term productive infection in NOD/SCID mice
... injected NOD/SCID mice intravenously with purified virus and measured latent and lytic viral transcripts in distal organs over the subsequent 4 ...
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Human Interleukin-15 Improves Engraftment of Human T Cells in NOD-SCID Mice
... in NOD-SCID mice after transfer of human periph- eral blood mononuclear ...treated mice than in those of untreated control ...of NOD-SCID ...grafted mice administered HBBS ...
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Experimental Infection of NOD/SCID Mice Reconstituted with Human CD34+ Cells with Epstein-Barr Virus
... of NOD/SCID mice that were reconstituted with human CD34 ⴙ cells by EGFP- tagged ...recipient mice with the recombinant virus ...from mice infected with the EGFP-tagged virus resulted ...
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Suppression of human breast tumors in NOD/SCID mice by CD44 shRNA gene therapy combined with doxorubicin treatment
... First, we established a breast cancer stem cell line that stably expressed GFP to monitor the xenografted breast cancer tumor in mice. To establish this cell line, breast cancer stem cells were transduced with a ...
8
CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells
... downregulation of CXCR4 by CXCL12 stimulation. In addition, CXCR7 contributes to homing of acute myeloid leukemia and normal progenitor cells to the bone marrow and spleen of NOD/SCID mice. In ...
5
Ahmed, Farid (2007): Role of the ABC transporter ABCG2 in human haematopoiesis. Dissertation, LMU München: Medizinische Fakultät
... The NOD/LtSz-scid strain was generated by crossing the SCID mutation from ...17- scid mice onto the NOD background. C.B-17-scid mice lack functional T & B ...
91
Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system
... immunodeficient mice, i.e. GFP nude mice [9], NOD/SCID EGFP mice [6] and NOG- EGFP mice [7], have been ...fluorescent mice were very useful to study the details of ...
7
Autocrine stimulation of VEGFR 2 activates human leukemic cell growth and migration
... of NOD-SCID mice. On HL-60– and HEL–injected mice, the percentage of human leukemic cells in the bone marrow was quantified by staining for human specific antigens and analyzed by flow ...from ...
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Previously undetected human hematopoietic cell populations with short term repopulating activity selectively engraft NOD/SCID β2 microglobulin–null mice
... phomyeloid cells that repopulate NOD/SCID mice (30, 36). Parallel differences between short and pro- longed durability of engraftment and low and high sensitivity to cell cycle progression have been ...
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Applying toponome imaging system for studying colon cancer
... Two scientific groups reported that colon cancer cells expressing CD133 were uniquely capable of initiating, proliferation and sustaining the tumour in NOD/SCID mice and therefore claime[r] ...
217
Passive transfer models of myasthenia gravis with muscle-specific kinase antibodies
... IgG1-3 fraction of the same MuSK MG patient did not induce any signs of in vivo disease and functional or histological NMJ aberrations in dissected muscles. A possible explanation for the lack of effect from IgG1-3 IgG ...
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Utility of Humanized BLT Mice for Analysis of Dengue Virus Infection and Antiviral Drug Testing
... BLT mice to generate the DENV-specific effector T cells by priming with DENV-infected dendritic ...DENV-infected mice with DENV-infected DCs, which are capable of presenting DENV-2 Col epitopes in the ...
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Highly purified Th17 cells from BDC2 5NOD mice convert into Th1 like cells in NOD/SCID recipient mice
... into NOD/SCID recipient mice. Induction of diabetes in NOD/ SCID mice via adoptive transfer of Th1 cells from ...transgenic mice was prevented by treatment of the ...
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Alteration of intra pancreatic target organ specificity by abrogation of Aire in NOD mice
... Aire-deficient NOD mice with at least a similar frequency to that in Aire-sufficient NOD ...Aire-deficient NOD mice demonstrated resistance to the develop- ment of diabetes, both in ...
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Soluble Rank Ligand Produced by Myeloma Cells Causes Generalised Bone Loss in Multiple Myeloma
... C57BL/KaLwRij mice were injected with either 5T2MM or 5T33MM murine myeloma ...5T2MM-bearing mice developed osteolytic bone lesions ...5T2MM-bearing mice soluble mRANKL was increased ...
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Treatment with CD20 specific antibody prevents and reverses autoimmune diabetes in mice
... 2H7-treated mice (P = ...(B). NOD/SCID mice were injected intravenously with (a) 10 7 spleen cells from diabetic mice alone (filled circles); (b) ...
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Experimental transmission of Babesia microti by Rhipicephalus haemaphysaloides
... Transstadial persistence and transovarial transmission Infective nymphs were fed on BALB/c or NOD/SCID mice free of B. microti, and 337 were engorged and har- vested (Fig. 1). Five of the 40 engorged ...
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Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice
... BLT mice, also using polychromatic flow cytometry, with the gating scheme shown in ...BLT mice generated for the studies we report here also demonstrated high proportions of human CD45 ⫹ cells among the ...
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In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning
... in mice given secondary bone marrow transplants ...for SCID-X1 appears to have resulted in leukemia due to insertion into the oncogene LMO-2 ...into NOD/SCID mice shows that, on ...
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