Nogo-A
<p>Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling</p>
... neuron growth, preventing abnormal fi ber growth under physiological conditions to stabilize the central nervous system wiring. At the same time, axonal regeneration was inhibited under pathological conditions. 26 Studies ...
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Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy
... Using a growth enhancing treatment, intrathecal application of anti-Nogo-A antibodies for 2 weeks, after a unilateral subtotal photothrombotic stroke to the sensorimotor cortex, we observed a high degree of ...
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Dendritic Plasticity in the Adult Rat Following Middle Cerebral Artery Occlusion and Nogo-A Neutralization
... 2000). Nogo-A is expressed in oligodendrocytes and myelin, and in certain neuronal populations (Caroni and Schwab, 1988a; Chen et ...studies, Nogo-A has proven to be a powerful inhibitor of axonal growth ...
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Sex Differences in Stroke Recovery: Synaptic Proteins and the Growth Inhibitory Protein Nogo a
... al., 2002; Seymour et al., 2007; Tsai et al., 2007; Tsai et al., 2011) emanating from the contralesional motor cortex after treatment with anti-Nogo-A immunotherapy post-stroke. Specifically in these studies the ...
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Neuronal Nogo A regulates neurite fasciculation, branching and extension in the developing nervous system
... and Nogo-A KO DRG neurons in order to assess whether, upon contact, they can affect the phenotype of one ...and Nogo-A KO neurons did not associate with each other, but rather made frequent contact with the ...
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Extended Treatment Window Exists for Improving Sensorimotor Recovery Using Anti-Nogo a Immunotherapy in Adult Rats with Chronic Stroke Deficits
... antibody treatment groups (see experimental timeline Figure 3.1) with careful attention to balance pre-stroke deficit from post-stroke week 8 on the skilled reaching task. Antibody infusion was initiated at the beginning ...
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Sequential therapy of anti-Nogo-A antibody treatment and treadmill training leads to cumulative improvements after spinal cord injury in rats
... Anti- Nogo-A antibody treatment improved paw position during the swing phase on average but not at lift off and initial contact, and while paw position was rotated at initial contact and lift off, ...
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Upregulation of the zebrafish Nogo-A homologue, Rtn4b, in retinal ganglion cells is functionally involved in axon regeneration
... of Nogo-A/ RTN4-A in mammals is the cell ...by Nogo-A exposed on the surface of oligodendrocytes and CNS myelin ...exposed Nogo-A is also known as an inhibitor of neuronal plasticity and regulator of ...
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Original Article Expression of BDNF and Nogo-A after singular and repetitive mild traumatic brain injury in rats
... of Nogo-A in hip- pocampus CA1 area and secondary motor cor- tex M2-1 within 24 days ...3B, Nogo-A showed the similar fluctuation tendency in hippocampus CA1 area of smTBI rats as that in the rmTBI rats, ...
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Control of cell shape, neurite outgrowth and migration by a novel Nogo-A/HSPG interaction
... and Nogo-A-∆20 ...and Nogo-A-∆20 ...or Nogo-A-∆20 substrate in the presence of 1 µM JTE-013 or vehicle ...on Nogo-A-∆20 inhibition rescue in 3T3 ...
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Developmental Wiring of Specific Neurons Is Regulated by RET-1/Nogo-A in Caenorhabditis elegans
... protein Nogo-A; however, little is known about the role of Nogo-A in axon ...the Nogo-A homolog, ret-1, is required for the correct guidance of specific axons along the midline of ...
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Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1β release through the inhibition of Nogo-A expression
... the Nogo receptor (NgR) [14]. Three isoforms of the Nogo protein (Nogo-A, Nogo-B, and Nogo-C) and of the corresponding NgRs have been identified ...all Nogo proteins bear a ...
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Original Article Comparing the effect of neurotrophic factor induced MSCs (BMSC and DPSC) on the expression of myelin proteins Nogo-A and OMgp in a glaucoma rat model
... teins, Nogo-A and OMgp, in the engineered MSCs transplanted glaucoma rat ...of Nogo-A and OMgp was significantly reduced in the sam- ples treated with engineered ...of Nogo-A and OMgp to an extent ...
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The role of Nogo-A in axonal plasticity, regrowth and repair
... of Nogo-A delta20 in primary ...assembly, Nogo-A-delta20-containing signalosomes are retrogradely transported to the cell body in which they activate RhoA, downregulate cAMP response element- binding ...
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Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload
... in Nogo-A/B–deficient ...whereby Nogo-A/B–deficient mice were protected from pathological cardiac hypertrophy during chronic pressure overload, SPT activity was inhibited with myriocin 1 day before and on ...
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Nogo B receptor increases the resistance to tamoxifen in estrogen receptor positive breast cancer cells
... including Nogo-A, Nogo-B and Nogo-C, are members of a reticulon protein ...superfamily. Nogo-B is mainly expressed in peripheral tissues ...a Nogo-B receptor specific for the amino ...
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Nogo receptor complex expression dynamics in the inflammatory foci of central nervous system experimental autoimmune demyelination
... previous Nogo-A findings, establishing that inter- action of Nogo-A and NgR in the different phases of the EAE course plays a significant role in disease progres- sion, accounting for inhibition of neurite ...
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Using Gene Knockout and Transgenic Approaches to Evaluate in vivo Functions of CNS Regeneration Inhibitors: How Important is Nogo?
... axonal Nogo-66 receptor (NgR) expressed by CNS neurons (He, ...and Nogo have been shown to bind with high affinity to NgR (He, ...for Nogo-A, B, C— all converge on a selection of distinct binding ...
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Essential roles of zebrafish rtn4/Nogo paralogues in embryonic development
... mammalian Nogo-A [18]. How- ever, downregulation of RTN4/Nogo-A in mammals does not obviously impair cell proliferation, neuronal differenti- ation or brain patterning in the early embryo ...of ...
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Original Article Nogo-C contributes to HCC tumorigenesis via suppressing cell growth and its interactome analysis with comparative proteomics research
... of Nogo-C in test samples convinces the specificity and efficiency of the immunopurifica- tion; Second, the identification of other mem- bers of Nogo family, coincident with the previ- ously reported ...
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