Non-Homologous End-Joining
Structural and Functional Characterization of Non-Homologous End Joining Factors
... are homologous recombination (HR) and non-homologous end joining ...or homologous chromosome as a template for repair, HR does not constitute the major repair pathway in mammals ...
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Original Article Blood-based DNA methylation of DNA repair genes in the non-homologous end-joining (NEHJ) pathway in patient with glioma
... Non-homologous end joining (NHEJ), one of the two major double-strand breaks (DSBs) repair systems, is the predominant type of DSBs repair induced by ionizing radiation and geno- mic ...
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Increased non-homologous end joining makes DNA-PK a promising target for therapeutic intervention in uveal melanoma
... Therapies, such as ionising radiation (IR) and MMC, work by inducing DNA damage. A cell’s DNA damage response (DDR) involves a complex interplay of pathways designed to recognise and repair lesions occurring during ...
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Genetic Interaction Between the Non-homologous End Joining Factors during B and T Lymphocyte Development: In Vivo Mouse Models
... Abstract: Non-homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double strand breaks (DSBs) throughout the course of the cell ...
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Non-Homologous End Joining Plays a Key Role in Transgene Concatemer Formation in Transgenic Zebrafish Embryos
... that non-homologous end joining (NHEJ) was the principal mechanism of exogenous gene concatemer formation and integration of transgenes into the genome of transgenic ...
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Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining
... and non-irradiated (−) ...HR, homologous recombination, MMR mismatch repair, NER nucleotide excision repair, NHEJ non-homologous end ...
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SIRT1 inhibition impairs non-homologous end joining DNA damage repair by increasing Ku70 acetylation in chronic myeloid leukemia cells
... (MMR), homologous recombination (HR) and non- homologous end joining (NHEJ) ...include end-binding and end-processing proteins Ku70, Ku80, DNA-PKcs and Artemis, as well as ...
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Characterizing the Function of Helix Five of the Ku70 von Willebrand A Domain in Non-Homologous End Joining
... DNA double strand breaks (DSBs) are a toxic and dangerous form of DNA damage repaired primarily by non-homologous end joining (NHEJ) in mammals. The Ku70/80 heterodimer rapidly responds to ...
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The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance
... Recent studies suggested that the FA pathway promotes the error-free HR repair pathway while suppressing the error-prone non-homologous end-joining (NHEJ) path- way [12–15]. Using FA-deficient ...
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Heat shock factor 1, an inhibitor of non-homologous end joining repair
... DNA double-strand breaks (DSBs) arise from normal cellular processes, as well as from exogenous sources, such as IR or other forms of genotoxic stress. DNA DSBs are repaired by either homologous recombination (HR) ...
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Merotelic attachments and non-homologous end joining are the basis of chromosomal instability
... Non-homologous end joining appears to be especially important when spindle checkpoint control is relaxed, because the increase in uncorrected merotelic attach- ments could promote chromosome ...
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Genome sequencing of evolved aspergilli populations reveals robust genomes, transversions in A. flavus, and sexual aberrancy in non-homologous end-joining mutants
... the non-homologous end-joining (NHEJ), which joins two DNA molecules that had suf- fered double-strand breaks (DSBs) ...by homologous recombination (HR) of double- strand breaks is only ...
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Harnessing accurate non homologous end joining for efficient precise deletion in CRISPR/Cas9 mediated genome editing
... accurate end joining, and filling in these ends by DNA polymerases can thus generate templated insertions in group ...curate end joining in group I may underestimate the true frequency of ...
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Double-Strand Break Repair by Non-homologous End-Joining
... The joining of protruding 5'-0H termini by human cell-free extracts was shown to be highly efficient and accurate, without loss or gain of nucleotides at the junction ...vitro end-joining studies, ...
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Nucleosome resection at a double strand break during Non Homologous Ends Joining in mammalian cells implications from repressive chromatin organization and the role of ARTEMIS
... Double Strand Breaks (DSBs) are the most serious form of DNA damage, yet they occur frequently by generation of reactive oxygen species during normal metabolism or by external agents such as ionizing radiation (IR). ...
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DNA repair and gene targeting in plant end-joining mutants
... namely non-homologous end joining (NHEJ) and homologous recombination ...lower end joining effi ciency, suggesting that NHEJ is a critical pathway for DSB repair in ...
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Imprecision and DNA break repair biased towards incompatible end joining in leukemia
... somatic mutations as well as somatic rearrangements in cancer genomes(1-3). Upon cancer therapy, subclonal refractory cells harboring acquired novel chromosomal aberrations or gene mutations can expand and may thus ...
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Microhomology-mediated end joining: new players join the team
... [3–5]. Non-homologous end joining (NHEJ) and homologous recombination (HR)-mediated DSB repair are two major pathways to fix DSBs [6, ...sical non-homologous end ...
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Efficient Gene Replacements in Toxoplasma gondii Strains Deficient for Nonhomologous End Joining
... of homologous recombination (25, 35, 39, 41). To verify that loss of non- homologous recombination is the explanation behind in- creased gene targeting efficiency in KU80 knockouts versus the ...
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Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1- dependent end joining in G1
... The process of choosing the appropriate DSB repair pathway is of great importance for the maintenance of genomic integrity. For instance, the engagement of NHEJ in replication- associated DSBs is linked to genomic ...
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