non-structural protein 3
“In silico Molecular Modelling and Docking Studies on Therapeutic Target Non Structural Protein 3 (NS3) of Dengue Virus 1” by Sakamoori Komala, Sahukari Ravi, Patan Usnantaj, Bhasha Shanmugam, Ganjikunta Venkata Subbaiah, Kesireddy Sathyavelu Reddy, India.
... synthesize structural and non structural proteins. Non Structural protein 3 (NS3) has serine protease and RNA helicase ...of Non Structural protein ...
5
Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription
... the non-structural proteins nsP1 to ...the structural proteins (capsid, envelope glycoproteins E1-3 and the 6K ...to 3 of the nsPs: nsP1 exhibits methyl- and guanyl-transferase ...
28
A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3
... the protein responsible for the neurodegenerative polyglutamine disease Spinocerebellar ataxia type ...Full structural characterisation of ataxin-3 is required to aid in understanding the mech- anism ...
9
The Effects of P320Sc Mutation in West Nile Non-structural Protein 1 (NS1) and the Generation of Aptamers to Detect Dengue NS1 in the Context of Infection.
... NS1 protein in patient blood, and rapid diagnostic test (RDT)- based detection of NS1, including laminar flow ...the 3’UTR can detect all four Dengue serotypes in a single reaction (168, ...
159
Topology and biological function of enterovirus non-structural protein 2B as a member of the viroporin family
... 2B protein on the efflux of Ca 2+ in the Golgi apparatus ...the protein transition pathway in cells to promote viral replication and repression of the anti- viral immune response of host ...
9
Development and characterization of serotype specific monoclonal antibodies against the dengue virus 4 (DENV 4) non structural protein (NS1)
... A total of six MAb-secreting hybridoma clones were iso- lated from SUMO*-DENV-4 rNS1 protein fusion primed splenocytes with Sp2/0 cells. A combination of three methods: western blot assay, iELISA and fixed cell ...
12
Insilico structural analysis of parasporin 2 protein sequences of non toxic bacillus thuringiensis
... sponding template (Figure 3). The final averaged and optimized model passed all the tests implemented in the stereochemistry-evaluating WHATCHECK suite [12-15] and in the VERIFY3D program, which uses contact po- ...
7
Non structural protein NS3/NS3a is required for propagation of bluetongue virus in Culicoides sonorensis
... Virus stocks were produced by infection of BSR cells at low multiplicity of infection (MOI), and were har- vested by freeze-thawing when > 50 % of cells immuno- stained as BTV-positive with α VP7 monoclonal antibody ...
9
Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71
... Enterovirus 71 (EV71), a positive single-stranded RNA and non-enveloped virus of the Picornaviridae family, generally causes mild diseases: e.g., fever, hand-foot- and-mouth disease (HFMD), herpangina. Sometimes, ...
14
Real life prevalence of resistance associated variants against non structural protein 5A inhibitors and efficiency of Daclatasvir + Asunaprevir therapy in Korean patients with genotype 1b hepatitis C
... proteins 3/4A protease inhibitors, NS5B nucleoside polymerase inhibitors, NS5B non-nucleoside polymerase inhibitors, and NS5A ...with non-overlapping ...
9
Development and validation of a prokaryotically expressed foot and mouth disease virus non structural protein 2C'3AB based immunochromatographic strip to differentiate between infected and vaccinated animals
... with non-structural protein (NSP) 2C’3AB was developed and validated to differentiate foot-and-mouth disease infected from vaccinated ...2C protein gene and whole 3AB gene were connected and ...
9
Environmental factors modulating the stability and enzymatic activity of the Petrotoga mobilis Esterase (PmEst)
... the protein contains both helical and strands elements (Fig 3), due to the presence of the two minima at the region of 222 and 208 nm, and the positive maximum at 196 nm that are charac- teristic spectral ...
17
Bluetongue virus non structural protein 1 is a positive regulator of viral protein synthesis
... NS3 protein sequences in the reporter protein a series of S10-GFP variants were ...and 3 0 ends of segment 10, but the length of the NS3 protein sequence fused to the GFP reporter is reduced ...
11
Dengue virus Non-Structural Protein 1: Roles in Replication and Immunity.
... (Chapter 3, Figure ...(Figure 3). This finding is consistent with our results in Chapter 3 showing that NS1 pretreatment leads to enhanced overall activation of DV infected ...
166
Functional studies of the group A rotavirus non structural protein NSP4
... the 3’ end of rotavirus mRNAs (Poncet et ...cellular protein synthesis (Piron et ...the 3’ end of viral mRNA has also been reported as being required for efficient translation of viral mRNA (Vende et ...
248
Biophysical evaluation of aminoclay as an effective protectant for protein stabilization during freeze-drying and storage
... on protein aggregation, protein formulations were prepared with aminoclay in a concentration range from ...after 3 months storage at 4 ° C and 40 ° ...after 3 months storage at 40 ° C, monomer ...
11
Molecular Cloning, Expression and Characterization of Para Flagellar Rod Protein 1 of Trypanosoma evansi
... PFR2 protein using pET32a vector, as His tagged fusion protein incorporating EcoRI and HindIII restriction sites in the expression pri- ...PFR2 protein is composed of 600 aminoacids (4). The ...
9
The Hepatitis C Virus NS2/3 Protease
... NS2 protein, what is the advantage for the virus of encoding two distinct proteases for polyprotein processing? Although several roles have been proposed for the cleaved NS2 protein, the NS2/3 ...
8
Yellow Fever/Japanese Encephalitis Chimeric Viruses: Construction and Biological Properties
... 14-2 virus is noneurovirulent compared to its JE SA-14 parent (6, 8), but sequence differences have been identified through- out their genomes (18), making it unclear which protein (or proteins) is a principal ...
7
Functional Characterization of Two Mutations Located in the Ligand Binding Domain in the SF1
... The structural analysis showed that, since it turns to be a less rigid protein, interactions are expected to be more labile for ...for structural packing (H2-E238 and H5-R313) and co- activator ...
8