Non‐targeted metabolomics study
Differentiating signals to make biological sense – a guide through databases for MS-based non-targeted metabolomics
... CONCLUSIONS Data analysis is a critical, but often an under-considered aspect of metabolomics research. In general, close to 50% of features detected in a non-targeted metabolomics ...
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Non targeted metabolomics in sport and exercise science
... concept study did not investigate the mechanistic effects of these changes, the study highlighted the potential for non-targeted metabolomics to identify changes in metabolites in ...
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Non-targeted and targeted metabolomics approaches to diagnosing lung cancer and predicting patient prognosis
... Our study had several ...The study was also limited in that the RRLC-based targeted metabolomics approach restricted the panel of candidate markers and only focused on amino acid metabolic ...
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Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality
... As a second example, we identified significant associations of genetic variants with 2-hydro- xyisobutyrate (2-HIBA) in a locus comprising 9 different genes. According to our evidence- based locus to gene assignment, ...
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Measurement of 1,5 anhydroglucitol in blood and saliva: from non targeted metabolomics to biochemical assay
... present study, we evaluated a possible method for measuring 1,5-AG in saliva samples using a set-up com- patible with clinical analytical ...based targeted metabolomics approach, how- ever it ...
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Development of a non-targeted metabolomics method to investigate urine in a rat model of polycystic kidney disease
... affect the concentration of metabolites in the urine and potentially cause significant variability in the metabolic profiles. To correct for this, creatinine was identified as a normalization strategy. As the focus of ...
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Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling.
... using metabolomics to study the incidence of type 2 diabetes have been focused only on characterizing the probability to develop the disease, but have mostly ignored the second aspect of ...
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Targeted metabolomics reveals the therapeutic impact of Eclipta prostrata on diet-induced non-alcoholic fatty liver disease in rats
... Non-alcoholic fatty liver disease (NAFLD) is a growing clinical problem worldwide. The current study aimed to evaluate the therapeutic effect of the methanol extract of Eclipta prostrata (E. prostrata) in ...
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Targeted redox and energy cofactor metabolomics in Clostridium thermocellum and Thermoanaerobacterium saccharolyticum
... in this study and others quantifying this parameter in C. thermocellum [18, 19]. Reduced nicotinamide cofactor losses cannot be accounted for in their oxidized counter- parts and ATP does not appear to be ...
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Metabolic engineering of a tyrosine-overproducing yeast platform using targeted metabolomics
... this study, it was determined based on previous experimental results for individual knock- outs [23, 24] that concurrent implementation of all GDLS design strategies for tyrosine production would not be ...this ...
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Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach
... the targeted metabolomics kit we used, as it does not provide a detailed analysis of the lipid composition of metabolites, such as PC ae ...in non-DM subjects in this ...
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Deep Exploration of Bifidobacteria through Metabolomics Study
... a non-targeted comprehensive scan, we established a metabolite data- base for ...particular, targeted analysis of lipids, bacteriocins, functional oligosaccha- rides, and absolute quantification of ...
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HRMS in Clinical Research: from Targeted Quantification to Metabolomics
... Basically the primary difference between HRMS and triple-quadrupole MS is that when performing triple-quadrupole MS analyses, the molecule to be determined is selected for monitoring bef[r] ...
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Oxidative and Non-Oxidative Metabolomics of Ethanol
... In addition to oxidative metabolism, ethanol also originates minor metabolites such as ethyl glucuronide (EtG), ethyl sulfate (EtS), ethyl nitrite (EtN), ethyl phosphate (EtP) phospha[r] ...
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Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma.
... our study is that a thorough visual inspection of the integration of the LC-MS/MS peaks is required for optimum ...for targeted LC-MS protocols to support correct peak identification as was the case for ...
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Targeted and non-targeted effects of ionizing radiation
... linear non-threshold model (LNT), possible risks from exposure to low dose ionizing ra- diation (below 100 mSv) are estimated by extrapolating from data obtained after exposure to higher doses of ...to ...
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NON-TARGETED COUNTIES
... Tax Returns Current year tax returns are required on all loans. The return must be signed by the borrowers and include all schedules and W-2s. Loan files received after April 15, 2012 must have the 2011 tax return in the ...
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Metabolomics Applied to the Study of Extracellular Vesicles
... Metabolite enrichment in exosomes can sometimes facilitate the detection of certain low-abundance disease markers which are below the detection limit using the sample matrix alone. However, careful quantification of ...
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AbsoluteIDQ p180 Kit. Targeted Metabolite Identifi cation and Quantifi cation. Bringing our targeted metabolomics expertise to your lab.
... The Biocrates AbsoluteIDQ p180 mass spectrometry Assay Preparation Kit delivers the widest range of metabolomic information available from a single targeted assay, covering a large number of key metabolites from ...
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Non-target effects of GM potato : an eco-metabolomics approach
... This study showed that large changes in metabolomic profiles occurred across years and locations, and throughout the growth period of plants within ...between metabolomics data and insect abundances on the ...
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