nonobese diabetic
Rotavirus Infection of Infant and Young Adult Nonobese Diabetic Mice Involves Extraintestinal Spread and Delays Diabetes Onset
... Rotaviruses have been implicated as a possible viral trigger for exacerbations in islet autoimmunity, suggesting they might modulate type 1 diabetes development. In this study, the ability of rotavirus strain RRV to ...
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Galantamine Attenuates Type 1 Diabetes and Inhibits Anti-Insulin Antibodies in Nonobese Diabetic Mice
... The nonobese diabetic (NOD) mouse is a model of type 1 diabetes, spontaneously developing antibodies against self- antigens, with islet infiltration starting at 3–4 wks, leading to later islet destruction ...
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Islet Endocrine-Cell Behavior From Birth Onward in Mice With the Nonobese Diabetic Genetic Background
... Background: Glucagon-producing cells play a crucial role during the perinatal period. Because of their peri-islet localization near the early dendritic and macrophage cell infiltration, we thought it pertinent to ...
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Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF beta1
... in nonobese diabe- tic (NOD) mice under the control of rat glucagon promoter (RGP) (NOD-RGP-TGF- b ...words: nonobese diabetic (NOD) mice • pancreatic islets ...
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Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon gamma transcription
... hyperglycemia and insulitis in nonobese diabetic (NOD) mice (Atkinson, M., N. Maclaren; and R. Luchetta. 1990. Diabetes. 39:933-937). The possible mechanisms responsible include reduced immunogenicity of ...
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Potent Anti-R5 Human Immunodeficiency Virus Type 1 Effects of a CCR5 Antagonist, AK602/ONO4128/GW873140, in a Novel Human Peripheral Blood Mononuclear Cell Nonobese Diabetic-SCID, Interleukin-2 Receptor γ-Chain-Knocked-Out AIDS Mouse Model
... 4 Potent Anti-R5 Human Immunodeficiency Virus Type 1 Effects of a CCR5 Antagonist, AK602/ONO4128/GW873140, in a Novel Human Peripheral Blood Mononuclear Cell Nonobese Diabetic-SCID, Inte[r] ...
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The Effect of High Carbohydrate Consumption on Glucose Levels and Antibody Production in Nonobese Diabetic Mice
... Nonobese diabetic mice (NOD) are an experimental model of type 1 diabetes, a multigene disease that mainly affects children and young adults and strongly depends on environmental factors such as stress, ...
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Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice
... The most widely studied animal model of autoimmune diabetes is the nonobese diabetic (NOD) mouse. Diabetes in NOD mice is a T cell-dependent disorder, with the major histocompatibility complex (MHC) locus ...
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Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice
... The nonobese diabetic (NOD) mouse strain exhibits immuno- logical, histopathological and physiological characteristics of SS with focal mononuclear cell infiltration of the exocrine glands from ...
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Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice
... We previously reported that administration of a streptococcal preparation (OK-432) inhibited insulitis and development of autoimmune diabetes in nonobese diabetic (NOD) mice and BB rats as animals models of ...
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Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium
... In the nonobese diabetic (NOD) mouse, lymphocytic and monocytic infiltration of the pancreatic islets leads to beta cell destruction. To investigate the mechanisms by which lymphocytes enter the NOD ...
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Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer
... The purpose of this study was to determine the effect of dendritic cell (DC) transfers on the incidence of diabetes in female nonobese diabetic (NOD) mice. Groups of 4-wk-old NOD female mice were given a ...
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Major histocompatibility complex linked diabetogenic gene of the nonobese diabetic mouse Analysis of genomic DNA amplified by the polymerase chain reaction
... the nonobese diabetic (NOD) mouse, an animal model of IDDM, in comparison with those of its sister strains, nonobese nondiabetic and cataract Shionogi (CTS) mice, and the original strain, outbred ...
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Inosine Protects Against the Development of Diabetes in Multiple-Low-Dose Streptozotocin and Nonobese Diabetic Mouse Models of Type 1 Diabetes
... Transplantation of islets into humans with type 1 diabetes has proved an effective therapy to produce insulin-independence (46), however immunosuppression may be required for life. Therefore, the search for ...
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Acute and steady state insulin responses to glucose in nonobese diabetic subjects
... Thus both basal and steady-state insulin levels of diabetics were comparable with those of normal subjects, which suggest that although the rapid insulin response from the storage pool o[r] ...
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Studies on the pathogenesis and prevention of insulin-dependent diabetes mellitus (IDDM) in the nonobese diabetic (NOD) mouse
... young diabetic would die before he had a chance to reproduce himself and to pass on the genes to succeeding ...a diabetic patient yielded a white powdery residue which when dried on cloth stained like ...
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Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice
... tration. Inflammatory infiltrates of pancreatic islets and sub- mandibular glands at early stages of disease are mainly composed of T cells (CD4 T cells in particular). B cells and macrophages increase progressively in ...
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Inhibition of submandibular and lacrimal gland infiltration in nonobese diabetic mice by transgenic expression of soluble TNF receptor p55
... diabetic (NOD) mouse has also been proposed as a valid ani- mal model for Sjögren’s disease due to the spontaneous occur- rence of lymphocytic infiltrates of the submandibular and lac- rimal glands (1). Unlike ...
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Reovirus Delays Diabetes Onset but Does Not Prevent Insulitis in Nonobese Diabetic Mice
... To determine whether the delay in diabetes onset associated with T3A infection is associated with blockade of insulitis, infected and control mice that had not developed glycosuria after[r] ...
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Perforin independent β cell destruction by diabetogenic CD8+ T lymphocytes in transgenic nonobese diabetic mice
... We found that a in vitro, 8.3-CTLs killed antigenic peptide–pulsed non–βcell targets via both perforin and Fas but killed NOD β cells via Fas exclusively; b unlike NOD.PO–/– mice, which [r] ...
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