Nonobese diabetic mice
The Effect of High Carbohydrate Consumption on Glucose Levels and Antibody Production in Nonobese Diabetic Mice
... Nonobese diabetic mice (NOD) are an experimental model of type 1 diabetes, a multigene disease that mainly affects children and young adults and strongly depends on environmental factors such as ...
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Prevention of diabetes in nonobese diabetic mice by dendritic cell transfer
... female nonobese diabetic (NOD) ...female mice were given a single foot pad of DCs (70-90% purity) isolated from the draining lymph nodes (LN) of the pancreas (PLN), the cervical LNs, or the ...
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Rotavirus Infection of Infant and Young Adult Nonobese Diabetic Mice Involves Extraintestinal Spread and Delays Diabetes Onset
... fant mice, unless virus was given ...infant mice (100%) ⬎ older mice inoculated i.p. (83%) ⬎ older mice inoculated orally ...from mice 12 days or 12 weeks after oral inoculation at 5 ...
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Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF beta1
... in nonobese diabetic (NOD) mice under the control of rat glucagon promoter (RGP) ...beta1 mice developed diabetes by 45 wk of age, in contrast to 40 and 71% in male and female nontransgenic ...
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Inhibition of submandibular and lacrimal gland infiltration in nonobese diabetic mice by transgenic expression of soluble TNF receptor p55
... NOD mice expressing an sTNFR p55-hg3 are consistent with a central role for TNF in the pro- gression of sialadenitis in NOD ...p55-hg3–expressing mice is paralleled by reduced expression of cell adhesion ...
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Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice
... NOD mice with circu- lating anti-M3R autoantibodies than in NOD mice lacking the same autoantibodies ...NOD mice, supported by the notion that no visible differences were observed in the distribution ...
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Perforin independent β cell destruction by diabetogenic CD8+ T lymphocytes in transgenic nonobese diabetic mice
... NOD mice (intercrossed at the N10 backcross) are also highly resistant to diabetes devel- ...these mice resulted from introduction of a putative, B6-derived, diabetes-resistant allele into the NOD ...
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Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL 10 transduced islet specific Th1 lymphocytes A gene therapy model for autoimmune diabetes
... NOD mice over 5 wk old (28). In isolated pancreatic islets of NOD mice, IL-10 and IFN-g mRNAs were detected with the semi- quantitative RT-PCR cycle number analysis after 40 and 35 cy- cles of PCR, ...
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Reversal of beta cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin dependent diabetes mellitus
... 12-13-wk-old mice displayed a lower glucose oxidation rate at ...NOD mice exhibit an impaired glucose metabolism, which may explain the suppressed insulin secretion observed immediately after ...
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Vasoactive intestinal peptide inhibits TNF α induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands
... Apoptosis of acinar cells from NOD submandibular glands. (a) Chromatin condensation and mRNA and protein expression of (b) Bax and (c) TP53INP1 were determined in acinar cells from non obese diabetic (NOD) at 16 ...
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Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium
... In the nonobese diabetic (NOD) mouse, lymphocytic and monocytic infiltration of the pancreatic islets leads to beta cell destruction. To investigate the mechanisms by which lymphocytes enter the NOD ...
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Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon gamma transcription
... in nonobese diabetic (NOD) mice (Atkinson, ...NOD mice, whereas immunizations with A-chain insulin or with BSA do ...insulin-immunized mice prevented diabetes in recipients co-infused ...
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Galantamine Attenuates Type 1 Diabetes and Inhibits Anti-Insulin Antibodies in Nonobese Diabetic Mice
... Changes in cellular populations could be an important component of galanta- mine’s antiinflammatory effects. To ex- amine changes in populations, we ob- tained single cell isolates from both spleen and total pancreas, ...
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Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice
... NOD mice, compared to those of T1D-protected E ␣ 16/NOD ...T1D-protected mice was revealed to be due mainly to members of the Clostridiales, including Clostridium, Eubacterium, Rose- buria, and ...
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Reovirus Delays Diabetes Onset but Does Not Prevent Insulitis in Nonobese Diabetic Mice
... NOD mice. In this study, we show that reovirus infection of newborn NOD mice delays the onset of overt ...NOD mice infected with reovirus, we think it unlikely that passive tolerance alone explains ...
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Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice
... NOD mice than in ...NOD mice still lack major signs of ...NOD mice cause massive lesions upon adop- tive transfer into NOD male recipients while, conversely, female recipients develop barely any ...
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Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice
... in nonobese diabetic (NOD) mice and BB rats as animals models of insulin-dependent diabetes ...NOD mice were the lowest producers of the mRNA of TNF and serum TNF on stimulation with OK-432 or ...
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Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma
... Sal-YB1 could significantly upregulate Toll-like receptor 4 (TLR4) expression in tumor tissues by flow cytometry. Inter- leukin 1 receptor-associated kinase (IRAK) ( P < 0.05) and nuclear factor of kappa light ...
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Ameliorative Effect of Chlorophyllin on Oxidative Stress in Experimental Model of Diabetes
... normal mice of Group A, b: diabetic mice of Group B, c: acid of Group C, and d: G: glomerulus, D: distal ubule, P: proximal convoluted tubule, BS: bowmen’s capsule space, and arrow showing dilatation ...
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Diabetic mouse models
... of diabetic animal models and patho- physiological analyses of the models are very important to aid in clarification of the pathogenesis and the patterns of progression in the human disease ...course. ...
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