nonribosomal peptide
Novel chemical probes for the investigation of nonribosomal peptide assembly
... echinomycin nonribosomal peptide assembly and in vivo capture of putative biosynthetic intermediates via chemical probes 3–17 (note: the general intermediate structures apply to all substrates with the ...
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An unusual Burkholderia gladioli double chain initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics
... metabolic arsenal of these bacteria is employed to eliminate other bacterial competitors and suppress plant pathogenic fungi and nematodes. In recent years various Burkholderia species have been shown to produce numerous ...
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“Detection of Nonribosomal Peptide Synthetase (NRPS) Genes on Bacterial Endophytes fromVetiveria zizanioides L. and Ageratum conyzoides L.” by Any Fitriani, Sandy Ahmad Herdiansyah, Indonesia.
... Polyketides, nonribosomal peptide, and their hybrid are a group of active compounds with antimicrobes ...and Nonribosomal Peptide Synthetase (NRPS) are group of enzymes involved in the ...
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Inactivation of the major hemolysin gene influences expression of the nonribosomal peptide synthetase gene swrA in the insect pathogen Serratia sp. strain SCBI
... Inactivation of the major hemolysin gene influences expression of the nonribosomal peptide synthetase gene swrA in the insect pathogen Serratia sp.. Petersen1[r] ...
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Functional Analysis of All Nonribosomal Peptide Synthetases in Cochliobolus heterostrophus Reveals a Factor, NPS6, Involved in Virulence and Resistance to Oxidative Stress
... of nonribosomal peptides for antibody production followed by screening of expression li- braries ...conserved nonribosomal peptide synthetase motifs (1, 22, ...
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Mining for nonribosomal peptide synthetase and polyketide synthase genes revealed a high level of diversity in the sphagnum bog metagenome
... Müller, Christina A., Oberauner-Wappis, Lisa, Peyman, Armin, Amos, Gregory C. A., Wellington, E. M. H. (Elizabeth M. H.), 1954-, Berg, Gabriele and Müller, V.. (2015) Mining for nonribosomal peptide ...
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Disruption of a Nonribosomal Peptide Synthetase in Aspergillus fumigatus Eliminates Gliotoxin Production
... The fungal secondary metabolite gliotoxin produced by Aspergillus fumigatus has been hypothesized to be important in the development of invasive aspergillosis. In this study, we addressed this hypothesis by disrupt- ing ...
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A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis
... Nonribosomal peptide synthases (NRPSs) are large multifunctional proteins involved in the biosynthesis of short peptides in a manner that is distinct from the ribosome- mediated translation of mRNA ...
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Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase
... hybrid nonribosomal peptide synthetase/ polyketide synthase (NRPS/PKS; Li et ...linear nonribosomal peptide–polyketide hybrid natural product 2 ...
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An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in Escherichia coli
... Here, we report an approach for the effective production and structural diversifica- tion of molecules produced by a nonribosomal peptide synthesis pathway. We suc- cessfully used ancestral or ortholog ...
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Retro inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer’s Aβ peptide
... To attach RI-OR2-TAT (Figure 1, A) covalently to the NL surface, we exploited a thiol-maleimide reaction employing an additional cysteine residue to provide the necessary thiol group. 23 This thiol function at the ...
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Altered peptide ligands inhibit arthritis induced by glucose 6 phosphate isomerase peptide
... Although one study used conventional APLs in collagen- induced arthritis [33], unconventional APLs with substitutions at MHC binding sites were mainly tested in arthritis models. Myers and colleagues reported that the ...
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A Review on Role of Peptide Vaccines in Cancer Therapy Treatment of Cancer Disease by Peptide Vaccine
... long peptide vaccines; multi-peptide vaccines consisting of CTL- and helper-epitopes; peptide cocktail vaccines; hybrid peptide vaccines; personalized peptide vaccines; and ...
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Peptide synthesis: evaluation of lipidic a-amino acids as drug and peptide delivery systems
... Boc-protected lipidic amino acid 37 was coupled to MBHA resin in a sintered glass tube attached to a mechanical agitator, using a solid phase method with double coupling. The sinter allowed convenient washing o f the ...
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Screening and identification of a renal carcinoma specific peptide from a phage display peptide library
... libraries on the surface of filamentous phage. Phage dis- play libraries permit the selection of peptides and pro- teins, including antibodies, with high affinity and specificity for all targets. An important distinctive ...
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Screening and Identification of a Targeting Peptide to Hepatocarcinoma from a Phage Display Peptide Library
... To identify the affinity of the seven se- lected phages with HepG2, cellular ELISA was performed to exclude false- positive colonies and those binding with equal affinity to HepG2 and controls. For calculating ...
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Tapasin enhances MHC class I peptide presentation according to peptide half life
... a peptide of usually 8–11 residues ...a peptide loading complex comprising transporter associated with antigen processing (TAP), tapasin, calreticulin, and ERp57 ...high-affinity peptide is ...
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Oxidation of the cyanobactin precursor peptide is independent of the leader peptide and operates in a defined order
... Here we report the first biochemical characterisation of a cyanobactin-type oxidase. We showed that the oxi- dases ThcOx and ArtGox operate on leaderless and full- length linear peptide substrates. We have ...
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DESIGN AND SYNTHESIS OF HANDLES FOR SOLID-PHASE PEPTIDE SYNTHESIS AND CONVERGENT PEPTIDE SYNTHESIS. A Dissertation
... I would like to thank my major professor Dr. Mark McLaughlin for his invaluable guidance and support during my stay at LSU. I am very grateful for the freedom and encouragement he gave me to develop my own ideas. A major ...
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A femtomolar acting neuroprotective peptide
... This is the first demonstration of a neuroprotective peptide with stress-protein–like sequences. Stress proteins, which are some of the most highly conserved and abundant proteins in nature, act as molecular ...
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