Norepinephrine transporter
A Novel Recombinant Vaccinia Virus Expressing the Human Norepinephrine Transporter Retains Oncolytic Potential and Facilitates Deep-Tissue Imaging
... human norepinephrine transporter (hNET), which can be imaged by single- photon emission computed tomography (SPECT) or positron emission tomogra- phy (PET) by using the radiotracer meta- iodobenzylguanidine ...
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Atomoxetine affects transcription/translation of the NMDA receptor and the norepinephrine transporter in the rat brain – an in vivo study
... The norepinephrine transporter (NET) inhibitor atomoxetine, the first nonstimulant drug licensed for ADHD treatment, also acts as an N-methyl-D-aspartate receptor (NMDAR) ...
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In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats
... in norepinephrine and norepinephrine transporter (NET) function and degeneration of the locus coeruleus produce irreversible impairments within the whole norepinephrine system, disrupting ...
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Alpha adrenergic modulation on effects of norepinephrine transporter inhibitor reboxetine in five-choice serial reaction time task
... a norepinephrine transporter (NET) inhibitor reboxetine (RBX) on an attentional performance ...a norepinephrine transporter inhibitor can be beneficial in both attentional accuracy and ...
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Altered expression of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion
... The norepinephrine transporter (NET) plays a major role as a specific uptake system for NE in synaptic membranes of neurons and is responsible for fast ter- mination of NE after neuronal release ...
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Norepinephrine transporter blocker atomoxetine increases salivary alpha amylase
... atomoxetine, a selective NE transporter blocker that increases central NE levels, to 24 healthy adult participants in a double-blind, placebo-controlled cross-over design. Atomoxetine administration significantly ...
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Sodium dependent norepinephrine induced currents in norepinephrine transporter transfected HEK 293 cells blocked by cocaine and antidepressants
... Re-sealed vesicles from PC-12 (pheochromocytoma) cells or placental brush-border cells are a more controlled alternative because they have fixed or imposed membrane potentials and ion gradients (Harder and Bönisch, 1985; ...
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Radiosynthesis and first preclinical evaluation of the novel norepinephrine transporter pet-ligand [11C]ME@HAPTHI
... In the autoradiographic experiments, the highest uptake of [ 11 C]Me@HAPTHI was observed in NET-rich re- gions identified with immunohistochemistry (Fig. 7). Blocking was performed with non-radioactive NET li- gands ...
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NET silencing by let-7i in postural tachycardia syndrome
... While strongly implicated in postural tachycardia syndrome (POTS), considerable controversy exists regarding norepinephrine transporter (NET) loss of function. POTS is characterized by the clinical symptoms ...
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Dynamic interaction of genetic risk factors and cocaine abuse in the background of Parkinsonism – a case report
... Dopamine transporter; DaTscan: Dopamine transporter single photon emission computerized tomography; DAT-SPECT: Dopamine transporter single photon emission computed tomography; DIP: Drug-induced ...
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dat sar 2 beta substituted tropanes pdf
... 2-position steric bulk in the benztropine class, as it does with the 2-substituted 3-aryltropanes. In addition, binding affinities at the serotonin transporter, norepinephrine transporter, and ...
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Role of an Expanded Inositol Transporter Repertoire in Cryptococcus neoformans Sexual Reproduction and Virulence
... major transporter, and its abundant mRNA is transcriptionally and posttranslationally repressed by inositol and ...minor transporter that is constitutively expressed at a low level (18, ...myo-inositol ...
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The translational expression of ABCA2 and ABCA3 is a strong prognostic biomarker for multidrug resistance in pediatric acute lymphoblastic leukemia
... Keywords: ABCA2 transporter, ABCA3 transporter, multidrug resistance, childhood acute lymphoblastic leukemia, molecular docking, tertiary structure.. Introduction.[r] ...
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Molecular physiology of norepinephrine and serotonin transporters
... amine transporter function have have traditionally relied upon whole cell and membrane vesicle measurements of radiolabeled neurotransmitter uptake and efflux (Kanner and Schuldiner, 1987; Humphreys et ...of ...
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Expression and regulation of drug transporters in vertebrate neutrophils
... “False negatives” may occur due to the inherent biological variation of the experimental approach, solubility issues or the fact that the compound cannot reach its intracellular target. In the latter case, we suggest ...
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Synthesis of Novel Azetidines
... Substitutions at the 3-positon of the aryl moiety of WIN 35,065-2 were also synthesized and analyzed for their binding affinities. However, it was determined 3- substitution does not affect the dopamine ...
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Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function
... In other ABC transporters, an EAA motif with conserved glu- tamates in the coupling helices is also important for both the as- sembly and the function of the transporter (30, 31, 34). It has been proposed that ...
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Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd Ameliorates hyperuricemia and acute gouty arthritis in animal model
... URAT1, GLUT9 and OAT1. URAT1, which is located in the brush border membrane of the renal tubular epithelial cell is responsible for reabsorption of urate transporter. This protein is encoded by the SLC22A12 gene, ...
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Pulmonary and Circulatory Effects of Acute Pulmonary Vascular Engorgement in Normal Subjects
... Changes during G suit inflation writh norepinephrine infusion Table IV G suit inflation during norepinephrine infusion resulted in a marked immediate increase in central venous pressure [r] ...
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Adrenoceptor stimulation does not affect ICAM 1 and VCAM 1 expression in vitro
... We found an effect of bacterial stimulation on ICAM-1 and VCAM-1 adhesion molecule expression which was not markedly influenced neither by admin- istration of the b1-adrenergic agent norepinephrine nor the ...
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