Normal cartilage
Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage
... study, cartilage samples were exclusively obtained from areas with mild to moderate macroscopic alterations - which may contain higher numbers of vital ...in normal-appearing and degraded OA ...
15
Collagenase and collagenase inhibitors in osteoarthritic and normal cartilage
... incorporated counts of the collagen substrate, whereas normal cartilage released 10.1% and a trypsin control, 6.4%. Electrophoresis of the degradation products of the enzyme- collagen complex incubated at ...
9
The Relationship between HIF 2α and VEGF with Radiographic Severity in the Primary Osteoarthritic Knee
... The expression of HIF-2α and VEGF was measured by real time-PCR and western blotting in samples acquired from the 29 patients with knee OA, 16 patients who underwent knee ar- throscopy, and 5 patients with normal ...
6
Different responses to mechanical injury in neonatal and adult ovine articular cartilage
... to cartilage injury in neonatal and adult sheep by microarray analysis of gene ...injured cartilage relative to normal ...injured cartilage relative to normal ...adult normal ...
14
Kniest dysplasia is characterized by an apparent abnormal processing of the C propeptide of type II cartilage collagen resulting in imperfect fibril assembly
... age-matched normal cartilages: fibrils were much thinner, of irregular shape and did not exhibit the characteristic banding ...with normal cartilage) of the C-propeptide of type II collagen ...
12
Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?
... in normal cartilage [41- 51] may be explained by the destruction of MMP-13 by other peptidases related to digestion or possibly due to the very low rate of its synthesis in this tissue ...by ...
11
Gene expression profile of the cartilage tissue spontaneously regenerated in vivo by using a novel double network gel: Comparisons with the normal articular cartilage
... marrow blood contains mesenchymal stem cells, which can differentiate into cartilage tissues. In addition, recent studies have shown that, in autologous chondrocyte transplantation, quality of the tissue located ...
12
Repression of anti proliferative factor Tob1in osteoarthritic cartilage
... osteoarthritic cartilage (10 sam- ples) and pooled normal cartilage was amplified and labeled with Cy3-UTP and Cy5-UTP respectively (Amer- sham Pharmacia) using the MessageAmp aRNA kit ...
11
Expression of 92 kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1
... osteoarthritic cartilage, but not in normal adult articular ...from normal cartilage also exhibited mRNA for 72-kD type IV collagenase/gelatinase (gelatinase A), tissue collagenase, and ...
8
Enhanced chondrocyte culture and growth on biologically inspired nanofibrous cell culture dishes
... than normal cartilage, the increased growth of chondrocytes on the surface as compared with normal cell culture choices (such as Corning and Falcon) and its natural extracellular matrix-like ...
5
Collagen synthesis in normal and osteoarthritic human cartilage
... articular cartilage was compared to that in normal cartilage and was also correlated with the degree of severity of the osteoarthritic lesion as determined by a histological-histochemical grading ...
9
Influence of bone morphogenetic protein on articular cartilage regeneration following periosteal grafting
... the cartilage defect area was replaced by semitransparent, smooth, pink and slightly swollen cartilage-like tissue, which formed a clear boundary from the surrounding ...the cartilage defect was ...
6
Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis
... OA cartilage [14] and a recent study indicates that Notch- 1-positive cells and its signaling components, Jagged1 and Hes5, are upregulated in OA and mediate cell proliferation ...OA cartilage is notable ...
13
MMP13 is a critical target gene during the progression of osteoarthritis
... performed on the right hind limbs as follows: 1) following anesthesia, making a 5 mm parapatellar; 2) identifying and transecting the medial collateral ligament with a 25 gauge needle; 3) applying valgus stress to the ...
11
Mitochondrial respiratory chain dysfunction modulates metalloproteases 1, 3 and 13 in human normal chondrocytes in culture
... Other authors have demonstrated that the regulation of the MRC function can directly affect the composition of the ECM [50]. For instance, De Cavanagh et al. have hypothesized that the depression of mitochondrial energy ...
10
ANOMALIES OF THE LARYNX ASSOCIATED WITH TRACHEO-OESOPHAGEAL FISTULA
... by )rOjection of a relatively large cricoid cartilage into the laryngeal lumen. The general shape of the cnicoid was normal. This contrast with the more usual examples of laryngeal steno[r] ...
7
Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
... Articular cartilage is composed of chondrocytes embedded in an extracellular matrix ...articular cartilage is aggrecan (AGC1); smaller components include the small leucine-rich proteogly- cans such as ...
9
Preferential mRNA expression of prostromelysin relative to procollagenase and in situ localization in human articular cartilage
... the cartilage remaining on late-stage osteoarthritic joints were lower than those in normal adult ...all cartilage zones were observed to express prostromelysin ...the normal adult ...
10
The Glycosaminoglycans of Normal and Arthritic Cartilage
... The cartilages from the hip joints of 13 normal and 15 osteoarthritic humans were analyzed for glycosaminoglycan content and distribution. The GAGs were separated by elution with CPC on a short cellulose column by ...
9
Quantification of Chondrocyte Apoptosis in Mechanically Impacted Articular Cartilage
... Osteoarthritis is a severe degenerative joint disease and. The symptoms associated with osteoarthritis are well documented, but the bone matrix changes that trigger onset of osteoarthritis disease have yet to be fully ...
111