Normal mammary gland development
ER and PR signaling nodes during mammary gland development
... 145. Ramamoorthy S, Dhananjayan SC, Demayo FJ, Nawaz Z: Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development. Mol Endocrinol 2010, 24:2099-2113. 146. ...
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Key signalling nodes in mammary gland development and cancer: Myc
... throughout normal mammary gland development, downstream of one or more of these ...in normal development is shown in Figure ...
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NEW INSIGHTS OF MAMMARY GLAND DURING DIFFERENT STAGES OF DEVELOPMENT
... alveoli development does not occur before ...lobuloalveolar development requires both estrogen and progesterone that is why this growth pattern is not found in estrous cycle where surge of either estrogen ...
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CD44 and Hyaluronan in the Regulation of Mammary Gland Development and Breast Cancer Progression
... during normal mammary gland development, as processes that occur in development mirror cancer progression and rely on conserved signaling pathways making it a powerful model system to ...
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Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues
... impaired mammary gland development during pregnancy have been observed in several knockout mouse models, and these models have enhanced our understanding of the roles of hormones and growth factors ...
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Investigating RUNX transcription factors in mammary gland development and breast cancer
... 1.1.2 Mammary gland development: an overview. The mammary gland is a very dynamic tissue which undergoes dramatic changes during different developmental phases (Richert, 2000; ...
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Epigenomics of mammary gland development
... Relevance to breast cancer There is increasing evidence that different breast cancer subtypes arise from distinct developmental stages along the differentiation hierarchy and retain characteristics of their cell of ...
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Vitamin D and the mammary gland: a review on its role in normal development and breast cancer
... cancer development are only sparsely understood, but evidence shows that vitamin D participates in cell growth regulation, apoptosis and cell diff ...the mammary gland, with a special focus on breast ...
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Homeobox genes in mammary gland development and neoplasia
... Both normal development and neoplastic progression involve cellular transitions from one physiological state to ...maintain mammary cell identity and dictate cell type-specific responses to ...
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Keratin 6 is not essential for mammary gland development
... the mammary gland is not known, so we examined the expression pattern throughout mammary devel- opment, as well as the mammary gland phenotype of mice that are null for both K6a and K6b ...
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Post-translational modifications in mammary gland development and mammary tumor progression
... Neoplasia describes the state of neoplasm growth. The type of proliferation in neoplasia is called neoplastic proliferation, as the cells do not die as they should and divide more quickly, forming tissue without ...
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Key stages in mammary gland development: The mammary end bud as a motile organ
... –/– mammary glands, there was a marked reduction in ductal outgrowth into the mammary fat pad that was accompanied by increased lateral branching ...of mammary outgrowth; it therefore seemed that ...
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Key stages in mammary gland development Secretory activation in the mammary gland: it's not just about milk protein synthesis!
... characterizing mammary gland differentiation and lactation, most investigators have focused upon the synthesis of milk proteins, particularly the caseins, since they form a well- defined set of molecules ...
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Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development
... of mammary gland ...the mammary stroma is also infiltrated with migrating blood cells, mostly macrophages and ...postnatal mammary gland development through to ...in ...
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ID4 regulates mammary gland development by suppressing p38MAPK activity
... of normal mammary cells as well as cultured mammary tumor ...These normal and tumorigenic functions of ID4 were primarily achieved by suppressing p38MAPK ...
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Epithelial vimentin plays a functional role in mammary gland development
... Statistical analysis Sample size for the studies was chosen according to previous studies in the same area of research. A minimum of three mice were analysed for each genotype for comparison, except for Fig. 2H,J, where ...
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Amphiregulin Mediates Estrogen, Progesterone, and EGFR Signaling in the Normal Rat Mammary Gland and in Hormone-Dependent Rat Mammary Cancers
... E+P-treated normal mammary glands. However, tumor development was notably associated with an increased percentage of cells expressing only PRA and a reduced percentage of cells expressing only ...
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Distinct expression patterns of ER alpha and ER beta in normal human mammary gland
... the development and matura- tion of the mammary ...murine mammary gland have shown that cells that are immunopositive for ERα very rarely undergo proliferation, as determined by the lack of ...
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PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors
... array. Interestingly, total PTK6, but not active PTK6, was detected in epithelial cells of normal glands. Like previously reported for the prostate, PTK6 protein was frequently localized to nuclei in normal ...
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Key signaling nodes in mammary gland development and cancer: β catenin
... of mammary development and ...ing mammary epithelial ...for mammary stem cell biology during mammary develop- ...in normal mammary development, and the eff ects of ...
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