Notation for the hERG Potassium Channel
Eag and HERG potassium channels as novel therapeutic targets in cancer
... gated potassium channels have been extensively studied in relation to ...two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential ...
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Mechanisms underlying probucol-induced hERG-channel deficiency
... probucol-induced hERG-channel ...of hERG channels localized in the ...of hERG-channel ...the hERG chan- nel, which is a direct substrate of ...decrease hERG expression and ...
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Long QT Syndrome-associated Mutations in the Per-Arnt-Sim (PAS) Domain of HERG Potassium Channels Accelerate Channel Deactivation*
... in HERG (13, 14, 29), the 8 amino-terminal mutant HERG sub- units formed functional channels when expressed alone in Xe- nopus ...WT HERG and mutant HERG channels exhibit weak inward ...mutant ...
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A functional Kv1.2-hERG chimaeric channel expressed in Pichia pastoris.
... the hERG channel for function in Xenopus oocytes and for overexpression in ...of HERG showed functional and pharmacological properties similar to hERG and could be overexpressed and purified ...
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Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
... block hERG currents expressed in HEK-293 cells and Xenopus oocytes after acute ...induced hERG channel reduction by disrupting channel ...blocking hERG channel and indirectly ...
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Potassium Channel and Glioma
... study, potassium channels are the best characterized with established role in cell cycle ...regulation. Potassium channels are transmembrane proteins that are defined by their ability to selectively ...
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An overview of the potassium channel family
... + channel automatically implies a negative-going change in electrical voltage across the cell ...+ channel, probably for volume regulation and maintenance of cell ...
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Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2
... the hERG potassium channel which has an unusual longer turret with the considerable conformational ...for hERG channels from scorpion Mesobuthus martensii, the turret role of hERG ...
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Potassium channel-based optogenetic silencing
... nucleotide-gated potassium channel ...sustained potassium-mediated hyperpolarization, conferring high operational light sensitivity to the cells of ...
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Potassium channel blockers as potential antisickling agents
... calcium channel blocker, was also shown to block IKca in red blood cells with A23187 stimulated K+ efflux at 100 pM, and in addition, inhibits Ca^+- dependent binding of calmodulin to the erythrocyte ...
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In silico structure analysis of potassium channel Bgk toxin and its docking prediction with human voltage gated potassium (Kv) channel
... ABSTRACT Kappa actitoxin Bg1a or Potassium channel Bgk toxin is voltage-gated potassium (Kv) channel blocker toxin extracted from sea anemone Bunodosoma granulifera. The present study ...
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Permeation Mechanism of Potassium Ions through the Large Conductance Ca2+-Activated Potassium Channel
... Motivation is an important factor for water molecule to pass through SF. Water molecules are independent of K + s inside SF because K + s are dehydrated inside SF. Under 𝑅𝑅𝐾𝐾 �����⃑ of the Slo1 channel, neutral ...
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Pulmonary vasoconstrictor action of KCNQ potassium channel blockers
... Conclusion The KCNQ K + channel blocking drugs, linopirdine and XE991, are potent and powerful constrictors of pulmo- nary arteries. This is a potentially serious side effect of the drugs and should be considered ...
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Investigation of the pharmacophore of BK[ca] potassium channel openers
... Xu et al (2001) define the requirements of an ideal HTS assay that include, sensitivity, specificity, through-put, robustness, information content, flexibility, cost and physiological relevance. Therefore to meet these ...
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Kinetic modeling of ion conduction in KcsA potassium channel
... a potassium channel of known structure that shows both high conduction rates and selectivity among monovalent ...this channel that assumes rapid ion transport within the filter has recently been ...
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Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells
... study, showing expression of Kv1.3 in three different glioma cell lines, is in agreement with these studies and in addition it provides for the first time evidence on the mitochondrial expression of Kv1.3 in glioma. ...
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Positive Trafficking Pathways of a Voltage Gated Potassium Channel
... 29 2.1. Abstract The Shaker family potassium channel, Kv1.2, is a key determinant of membrane excitability in neurons and cardiovascular tissue. Kv1.2 is subject to multiple forms of regulation and ...
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Calculation of the Gating Charge for the Kv1.2 Voltage-Activated Potassium Channel
... Kv1.2 potassium channel in the active and resting state, originally presented elsewhere, are here refined using molecular dynamics simulations in an explicit membrane-solvent ...the channel determined ...
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The Eag potassium channel as a new prognostic marker in ovarian cancer
... cancer. HERG expression did not show any dif- ference in survival indicating that HERG channels as targets may not have a therapeutic role in ovarian can- ...and HERG channels belong to the same Eag ...
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Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator
... of potassium, verapamil, calcium-free medium, and antagonists of the KCa channel (charybdotoxin, iberiotoxin) also blocked flow-mediated ...specific potassium channel to induce the release of ...
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