Notch Signaling Pathway
Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway
... between Notch signaling pathway and Math1 were identified in various ...of Notch via Jag2 was shown to inhibit expression of Math1 in cochlear progenitor cells, possibly through the activity ...
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Deciphering the anti angiogenic effect of endostatin/cyclophosphamide to normalize tumor micrangium through notch signaling pathway in colon cancer
... that NOTCH-3, JAG-1, and DLL-4 are among the most altered notch signaling genes in cancer ...of NOTCH-3 and JAG-1 is highly correlated and found to be upregulated in ...these notch ...
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Association between Notch signaling pathway and cancer
... the Notch signaling path- way can act as an oncogene or a tumor suppres- sor in many ...the Notch signaling pathway as a potential cancer treatment ...this pathway could be ...
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The Logic of Receptor Ligand Interactions in the Notch Signaling Pathway
... The Notch signaling pathway enables neighboring cells to coordinate developmental fates in diverse processes such as angiogenesis, neuronal differentiation, and immune system ...the Notch ...
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Notch signaling pathway mediates Doxorubicin-driven apoptosis in cancers
... of Notch pathway components in the Doxorubicin treated cells were determined by Real-Time ...multiple Notch pathway components in cancer cells. The Notch target HES1 is activated by ...
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The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis
... SHARP (or MINT) similarly assembles a repressor complex with CSL plus co-repressors, and is thus con- sidered a functional homolog of Hairless [13]. Repressor activity was demonstrated experimentally in cell culture as ...
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New Capabilities of the Notch Signaling Pathway
... thus signaling in receiving cells can be activated and modulated using recombinant ligand ...of Notch signaling requires manipulation of both ligand-expressing sender cells and receiver cells, and ...
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Original Article Regulation of calcium pump through Notch/Jagged/Hes signaling pathway in canine model of chronic atrial fibrillation
... the Notch signaling system in the myocardium may be reactivated under patho- logical ...increased Notch- 1 signaling transduction activity has been iden- tified in models of atherosclerotic ...
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VRTN is Required for the Development of Thoracic Vertebrae in Mammals
... variants may regulate the gene expression that in the Notch signaling pathway, resulting in more but shorter somites in pig. During fetal development, each segment of the vertebral column is formed ...
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Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice
... The Notch signaling pathway is involved in cell fate determination and has been implicated in proximal-distal patterning in the mammalian ...of Notch signaling in renal collecting duct ...
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Mutual regulation of JAG2 and PRAF2 promotes migration and invasion of colorectal cancer cells uncoupled from epithelial–mesenchymal transition
... elegans)-dependent Notch signal transduction and the non-canonical pathway is CSL-independent ...[7]. Notch precursor protein, encoded by the Notch gene, is synthe- sized in ribosome and then ...
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TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling
... We hypothesized that TQ-induced growth suppression of HCC cells could be related to the Notch signaling pathway. To confirm this possibility, we determined the effects of TQ on Notch ...
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Metastasis-associated lung adenocarcinoma transcript 1 promotes the proliferation of chondro­sarcoma cell via activating Notch-1 signaling pathway
... of Notch signaling pathway. MALAT-1 could activate the Notch-1 signaling pathway at posttranscriptional ...of Notch-1 reversed the effect of si-MALAT-1 on the ...
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Notch signaling deregulation in multiple myeloma: A rational molecular target
... of Notch signaling in MMSCs has been described on the basis of functional assays [56, ...of Notch signaling pathway, mediated by the overexpression of Notch receptors or ligands, ...
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The significance of Notch ligand expression in the peripheral blood of children with hand, foot and mouth disease (HFMD)
... Furthermore, Notch li- gands Dll1 and Dll4 are both involved in the initiation of an anti-viral response ...the Notch signaling is involved in the pathogenesis of ...the Notch signaling ...
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Original Article Pathway analysis of esophageal squamous cell carcinoma using iTRAQ-based quantitative proteomic approach
... signal pathway could be divided into five types including Notch signaling pathway, Wnt signaling pathway, NF- kappa B signaling path- way, Hedgehog signaling ...
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No Evidence for an Association Between Common Nonsynonymous Polymorphisms in Delta and Bristle Number Variation in Natural and Laboratory Populations of Drosophila melanogaster
... the Notch signaling pathway contribute to standing variation in sternopleural and/or abdominal bristle number in Drosophila melanogaster, for both a large cohort of wild-caught flies and previously ...
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Notch: a mastermind of vascular morphogenesis
... the Notch signaling pathway in the neural crest as an essential determinant of cardiovascular structure (see the related article beginning on page ...
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The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
... The Notch signaling pathway plays myriad roles in both developing and adult multicellular organisms (for reviews, see Baron, 2003; Gridley, 2003; Lai, 2004; Schweisguth, ...the Notch ligands ...
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Targeting Wnt pathway in mantle cell lymphoma-initiating cells
... tenin signaling in MCL-ICs and shown that inhibition of the Wnt pathway effectively eliminates MCL-ICs, which are implicated in MCL ...Wnt signaling inhibitors tar- geting β-catenin-TCF4 interaction ...
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