novel target
Nonconscious processing and a novel target for schizophrenia research
... potential novel target for schizophrenia research. To understand this target we reviewed the findings of neuroimaging studies on implicit (nonconscious) ...unstudied target for schizophre- nia ...
5
Review: Novel Target for Cancer Therapy
... It has been described recently that changes in the chromosome structure with modified histone protein play a significant role in the regulation of gene expression in eukaryotes. These modifications include methylation, ...
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Natriuretic peptide receptor A as a novel target for cancer
... The receptor for the cardiac hormone atrial natriuretic peptide (ANP), natriuretic peptide receptor A (NPR-A), has been reported to be expressed in lung cancer, prostate cancer and ovarian cancer. NPR-A expression and ...
6
Characterization of AFMP1: a Novel Target for Serodiagnosis of Aspergillosis
... We cloned the AFMP1 gene, which encodes the first antigenic cell wall galactomannoprotein in Aspergillus fumigatus. AFMP1 codes for a protein, Afmp1p, of 284 amino acid residues, with a few sequence features that are ...
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P2X7 receptors are a potential novel target for anti-glioma therapies
... In this study, we reveal increased P2X7R protein ex- pression in microglia cultured from human brain tumour versus ‘peri-tumour’ (region of macroscopically normal brain surrounding the frank tumour). Pore ac- tivity was ...
10
Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
... Benzamides including entinostat (MS-275 or SNDX-275) and mocetinostat (MGCD103) are another class of mole- cules that demonstrate specificity for class I HDACs. Enti- nostat is a novel and orally available ...
10
Original Article KLF-4 is a novel target of
... Yunke has been widely used in China for the treatment of OA with good efficacy, but the underlying molecular mechanism is unknown. KLF4 is a mediator of pro-inflammatory signal- ing in macrophages is via regulating M1/M2 ...
9
Mutant HRAS as novel target for MEK and mTOR inhibitors
... PI3K/mechanistic target of rapamycin (mTOR)-signaling cascade and combined inhibition of MEK and PI3K was synergistic in certain NRAS mutant cell lines of melanoma, lung cancer and neuroblastoma [14, ...
14
SOD1, an unexpected novel target for cancer therapy.
... The Varmus ‘s group has recently performed a high-throughput chemical screen to identify small molecule inhibitors of lung cancer cells. They reported the identification of LCS-1 as such a molecule, and subsequently ...
7
Bap31 Is a Novel Target of the Human Papillomavirus E5 Protein
... ability in heterologous cell types (4, 48). Several reports have implicated the epidermal growth factor receptor (EGFR), rather than the PDGF receptor, as a key player in the action of HPV E5. In the presence of EGF, E5 ...
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MICROTUBULE: A NOVEL TARGET FOR CANCER THERAPY
... For cancer therapy, microtubule network is an attractive cellular target. Main component of cell cycle is mitotic stage, particularly when the mitotic spindle separates the replicated chromosomes. The rapid ...
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Adenosine A2 Receptor: Novel Target for the Management of Parkinsonism
... There is a need for medications that can slow the underlying progression of degeneration, improve motor fluctuations and PD symptoms in early disease without inducing dyskinesia and ‘off’ time in advanced disease. Due to ...
5
SHP2 phosphatase as a novel therapeutic target for melanoma treatment
... Melanoma ranks among the most aggressive and deadly human cancers. Although a number of targeted therapies are available, they are effective only in a subset of patients and the emergence of drug resistance often reduces ...
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The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma
... ATPase activity with V0 rotation [1]. Multiple roles have been attributed to V-ATPase in physiological conditions, among which regulation of pH balance, control of neurotransmitter trafficking and degradation of ...
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AMPD1: a novel therapeutic target for reversing insulin resistance
... the data are consistent with activation of AMP kinase, a known pathway for decreasing insulin resistance, and potentially a novel mechanism of action that may involve the leptin receptor. The effects of reduced ...
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Dissection of the target specificity of the RNA binding protein HOW reveals dpp mRNA as a novel HOW target
... of target mRNA species required for tissue differentiation in a spatial and temporal fashion (Kuersten and Goodwin, 2003; Lasko, 2003; Larocque and Richard, 2005; Vernet and Artzt, ...
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Intracellular Receptor Modulation: Novel Approach to Target GPCRs
... information on the features that determine binding and selectivity in this intracellular binding site (Figure 3, Key Figure). Moreover, these structures provide new opportunities for the application of structure-based ...
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miRNA-21 as a novel therapeutic target in lung cancer
... Lung Cancer: Targets and Therapy is an international, peer-reviewed, open access journal focusing on lung cancer research, identification of therapeutic targets and the optimal use of preventative and integrated ...
9
NITRIC OXIDE: A NOVEL THERAPEUTIC TARGET
... Mechanisms involved in the regulation of Nitric Oxide Synthase Activity: At the post- translational level, NOS3 activity is highly regulated by 6 different mechanisms 24, 25; lipidation,[r] ...
13
Novel drugs that target the metabolic reprogramming in renal cell cancer
... Clinical experience with PI3K-AKT-mTOR inhibitors As downstream mediator of receptor tyrosine kinase (RTK) signaling as well as mutated hotspot itself, PI3K represents an attractive therapeutic target. A variety ...
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