Novel Therapeutic Targets
Novel Therapeutic Targets in the Brain Tumor Microenvironment
... Copyright: © Phillips et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided ...
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Advances in the proteomic discovery of novel therapeutic targets in cancer
... Dovepress Novel therapeutic targets in cancer presence in the pulled-down extract of nonspecifically bound ...unknown targets that may also bind to the ...protein targets for drugs that ...
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Eag and HERG potassium channels as novel therapeutic targets in cancer
... Both Eag and HERG channels have been shown to be present in cancers of differing origin and have a role in cell proliferation, progression and survival. There is abundant data on the effects of various blockers on the ...
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Novel Therapeutic Targets in Non-small Cell Lung Cancer
... myriad novel therapeutic targets currently being investigated in laboratory and clinical ...major therapeutic advances in cancer treatment demonstrated that most breakthroughs, by which drugs ...
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Multi-platform profiling of over 2000 sarcomas: Identification of biomarkers and novel therapeutic targets
... Using a registry of 2539 patients with bone and soft tissue sarcomas we have catalogued changes in protein expression, gene amplification/translocation, and somatic mutations. Herein we describe these findings with the ...
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Identification of Novel Therapeutic Targets in COPD
... COPD is an important lung and airway disease with an increasing incidence particularly in developing countries. Worldwide, asthma and COPD affect the lives of ~300 and 200 million people, respectively (1). COPD is a ...
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Quadruplex Nucleic Acids as Novel Therapeutic Targets
... containing complexes have been developed to target telomeric quadruplexes, 111 some of which are also potent telomerase inhibitors (see for example. 112, 113 ) Notable exceptions to the polycyclic + cationic substituted ...
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Novel therapeutic targets in pediatric neural tumors
... During the last decade, convincing evidence has emerged from several studies proposing PPM1D/WIP1 to be a potent regulator of cancer development. In paper III, we provided new evidence suggesting a pivotal role of WIP1 ...
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NOVEL THERAPEUTIC TARGETS ON THE HORIZON FOR LUNG CANCER
... candidate biomarkers and should occur in near real-time, permiting adjustments in the target population with emerging experience. This principle similarly applies in enhancing precision of a selection biomarker. Genomics ...
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Luminal B breast cancer and novel therapeutic targets
... HER2-negative tumors exists along a continuum. Identifi cation of highly proliferative ER-positive/HER2- negative tumors – whether through histological grading, the Ki-67 labeling index, or a multigene signature – is ...
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Novel therapeutic targets for the treatment of vincristine induced peripheral neuropathy
... a novel mouse model of VIPN based on local intraplantar injections of vincristine that allowed me to reproduce several symptoms of VIPN and allowed me to compare, in chapter three, differential gene expression ...
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IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives
... Abstract: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to α-ketoglutarate. IDH1/2 mutations define distinct subsets of cancers, including low-grade gliomas and ...
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Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets
... possible therapeutic targets for preventing the propagation of tau pathology, as inhibition of tau transfer may restrict development of tau tangles in a small subset of neurons affected in early stages of ...
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Advances in osteosarcoma stem cell research and opportunities for novel therapeutic targets
... Therapeutic targeting of osteosarcoma stem cells CSCs exploit various mechanisms to deregulate apoptotic sig- naling pathways, including the ability to enter quiescence and slow the rate of proliferation [86] . ...
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Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets
... Protease inhibitor-based strategies to resolve chronic wounds. The microenvironment of chronic wounds not only has reduced growth factor levels, but also has an imbalance of MMPs and TIMPs. This can lead to the ...
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In silico prediction of novel therapeutic targets using gene–disease association data
... between targets and diseases correlates with clinical fail- ure to build a machine learning framework able to make accurate predictions of therapeutic targets, exclusively using gene–disease ...
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Flavodoxins as novel therapeutic targets against helicobacter pylori and other gastric pathogens
... promising therapeutic targets to fight bacterial ...protein targets described for this bacterium and provide information on other gastrointestinal pathogens and also on bacteria from the gut ...
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Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease
... In response to acute IRI, fragmentation of the mitochondria by Drp1 was detected ( Ong et al., 2010 ; Din et al., 2013 ). The inhibi- tion of Drp1 in the HL-1 cardiac cell line using genetic or phar- macological ...
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Novel Therapeutic Targets for Ph+ Chromosome Leukemia and Its Leukemia Stem Cells: A Dissertation
... Hsp90 and LSCs Another exciting finding in this part of work is inhibition of Hsp90 could impair LSCs in vitro and in vivo. As CML is a disease derived from cancer stem cells, it has become a paradigm model in cancer ...
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The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes
... Scope of review: In this review, we discuss the experimental data indicating a critical role for IGF/IGFBP axis in metabolic regulation. We highlight key discoveries through which IGFBPs have emerged as biomarkers or ...
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