Nrf2 activation
Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 Activation in Latently Infected Endothelial Cells through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1
... releasing Nrf2 from Keap1 ...virus-mediated Nrf2 ac- tivation, through either ROS-dependent or independent mecha- nisms, arguing for an important role for Nrf2 in the viral life ...in Nrf2 ...
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Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer
... by Nrf2 activation via PI3K/Akt pathway in primary mouse embryonic fibroblasts from wild-type or Nrf2 knockout C57BL6J mice and ST-2 cells ...by Nrf2 protein ...the Nrf2-dependent ...
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Nrf2 Activation by Dimercaptopropanol Attenuates Mutant Huntingtin Toxicity
... as NRF2 activation, confirmed by augmented ARE-directed gene expression, increased nuclear localization of NRF2 and dramatically enhanced ARE- luciferase reporter ...of NRF2 NRF2 could ...
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BMP driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis
... of NRF2 are maintained through KEAP1-dependent ...of NRF2 and subsequent induction of NRF2 target genes including NAD(P)H quinine oxidoreductase-1 (Nqo1), which encodes an enzyme critical for ...
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Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation
... inflammasome activation, reactive oxygen species (ROS) and mononuclear leukocyte infiltration in the kidney have been shown to provoke the acceleration and deterioration of LN, such as accelerated and severe LN ...
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Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus
... the Nrf2 gene targets NADPH quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO-1), or γ-glu- tamyl cysteinyl ligase modulatory subunit (GCLM) (Supplemental Figure ...modify Nrf2 signaling activity, a ...
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Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice
... Hemopexin was at its lowest level at 1 month in both SS and control mice, suggesting that the expres- sion of this molecule may be developmentally regulated in mammals similarly to the pattern of expression in chicks ...
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Non-Canonical Activation of Nrf2 by Dimercaptopropanol as a Treatment for Huntington's Disease
... canonical Nrf2 activator, sulforaphane, it became evident that its protective effects are not due to Nrf2 activation alone: while DMP enhanced viability in 3-NP-treated STHdh Q111 cells with an ...
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Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies
... pharmacological activation of Nrf2 results in increased gene expression of Heme oxygenase 1 (Ho-1) and NAD(P)H quinone oxidoreductase 1 (Nqo1), which in turn have inhibitory effects on inflammation ...
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Acrolein exposure suppresses antigen-induced pulmonary inflammation
... the Nrf2 pathway through direct interaction with redox-sensing cysteine residues within its inhibitor Keap1 ...of Nrf2 protein, and in- duction of the Nrf2-regulated genes HO-1 and GCL, in- deed ...
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Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes
... activity, Nrf2 regulates the expression of several tar- get ...induces Nrf2 activation and the expression of its target genes, NQO-1 and ...by Nrf2, HIF-1α, and JNK, whereas that of NQO-1 was ...
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Coniferaldehyde attenuates Alzheimer's pathology via activation of Nrf2 and its targets
... subsequent Nrf2 activation accomplish these effects remain to be ...which Nrf2 alters ATP production have been reported, but the effects are dependent on the mechanism of activation, ...
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Coal tar induces AHR dependent skin barrier repair in atopic dermatitis
... of NRF2 in epidermal barrier function, its main function lies in the defense against oxidative stress, and it is there- fore proposed as a potential pharmacological target for chemoprevention ...(53). NRF2 ...
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Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease
... small-molecule Nrf2 agonist, as an activator of γ-globin transcription to enhance levels of HbF in SCD donor–derived erythroid progenitor cells, SCD transgenic mice, and nonanemic cynomolgus ...in Nrf2 ...
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A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure
... the activation of the Nuclear factor-erythroid-2-related factor 2 (Nrf2) ...the activation of the Nrf2 pathway after single chemical treatment, little is known about the dynamic regulation of ...
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Activation of NRF2 by p62 and proteasome reduction in sphere- forming breast carcinoma cells
... the NRF2 protein and target gene expression compared to the ...attenuate NRF2 activation. NRF2 increase was confirmed in sphere-cultures of the colon and ovarian cancer ...of NRF2 was ...
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Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
... or Nrf2 [19, 23]. In the heart, sustained activation of the Nrf2 pathway via Keap1 sequestration into mutant αB- crystallin aggregates leads to reductive stress, a shift of the cellular redox ...
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Cytoprotection “gone astray’’: Nrf2 and its role in cancer
... decade, Nrf2 inhibitors represent rational tools to prevent malignant progression in cancer, whereas activators of Nrf2 are obvi- ously more suited for cancer ...of Nrf2 fits into still-homeostatic ...
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Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001
... RRx-001 is a small molecular pan-epigenetic agent with ROS/RNS-generating properties that targets hypoxic tumor cells [11–13]. Antitumor activity has been demonstrated both in preclinical models and in patients with ...
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Nrf2 Activates Augmenter of Liver Regeneration (ALR) via Antioxidant Response Element and Links Oxidative Stress to Liver Regeneration
... by Nrf2 (Figure ...of Nrf2 activation in ARE- regulated ALR expression, we co- transfected HepG2 and Huh-7 cells with an ARE harboring luciferase reporter construct (–733 to +240) of ALR and con- ...
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