Nrf2/HO-1 pathway
<p>Methyl Jasmonate Protects Microglial Cells Against β-Amyloid-Induced Oxidative Stress and Inflammation via Nrf2-Dependent HO-1 Pathway</p>
... Nrf2. Furthermore, signi fi cant up-regulation (p<0.01) of in fl ammatory cytokines (IL-1 β , IL-6, TNF- α , TLR4 and p-NF- κ B) was observed in A β +MeJA+si-Nrf2 group and A β group compared with ...
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Original Article -acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway
... the Nrf2 defense pathway ...the Nrf2 pathway protect liver against CCl 4 -induced damage. HO-1 belongs to a family of cytoprotective and detoxification genes that possess AREs in ...
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Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... by HO-1 inhibitor ...of HO-1, Nrf2, and markers of neurons and astrocytes in ischemic ...that Nrf2/HO-1 pathway mediated the neuroprotective effect of XN ...
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Original Article Sulforaphane attenuates acute lung injury by inhibiting oxidative stress via Nrf2/HO-1 pathway in a rat sepsis model
... through Nrf2/HO-1 signaling ...using HO-1 inhibitor which showing that inhibition of HO-1 cancelled the beneficial effects of sulfora- phane on ALI in ...
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Original Article Effects of Sancai Lianmei Particle on autophagy and apoptosis in testes of diabetic mice via the Nrf2/HO-1 pathway
... The current study found that SCLM Particle sig- nificantly decreased FPG and HbA1c in DM mice, with effects equivalent to metformin. SCLM Particle may also attenuate oxidative stress injuries and inhibit testicular ...
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Knockdown of Nrf2 Inhibits the Angiogenesis of Rat Cardiac Micro-vascular Endothelial Cells under Hypoxic Conditions
... as HO-1. Recently, Sethy’s research reported that the HO-1 expression was upregulated in rat brain under short-term chronic hypobaric hypoxia in vivo ...stimulated HO-1 ...
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Inhibition of Nrf2/HO 1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis
... circumstances, Nrf2 is mainly present in the cytoplasm; however, when the level of ROS is elevated, the transcription of antioxidative stress proteins, including HO-1, is enhanced by Nrf2 [35, ...
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Original Article Effects of resveratrol on the Nrf2 and HO-1 expression in diabetic vascular endothelial cells
... oxygenase 1 (HO-1) genes, which are associated with elimination of ...of Nrf2 and HO-1 genes in retinal tissue were detected by fluorescence quantitative PCR, Western blot and ...
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Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway
... signaling pathway is considered to mediate cellular resistance to ...inhibited HO-1 expression and augmented the anti-tumor effect of ...EGCG-activated Nrf2/HO-1 pathway ...
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Baicalin mitigated Mycoplasma gallisepticum-induced structural damage and attenuated oxidative stress and apoptosis in chicken thymus through the Nrf2/HO-1 defence pathway
... for 1 h at room temperature, the membranes were washed three times with TBST and incubated with primary anti- bodies, including Nrf2 (1:500, Bioss Antibodies ...China), HO-1 ...
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Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer
... NaCl, 1 mM EDTA, 1 % Tripton X-100, 1 μM phenylmethylsulfonyl fluoride (PMSF), 1 % sodium deoxycholate, ...with Nrf2 antibody, HO-1 antibody, NQO1 antibody, GCLC antibody, ...
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Beneficial Impacts of N-3 Polyunsaturated Fatty Acids On Gold Nanoparticles -Induced Liver Injury by Activating Ppar? and Nrf2/Ho-1 Signaling Pathway
... The protective and therapeutic impacts of N-3 PUFA on the concentrations of oxidative stress indices in rat groups intoxicated with AuNPs are shown in Figures 2 & 3 respectively. The data illustrated that ...
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Original Article Overexpression of miR-153 promotes oxidative stress in MPP -induced PD model by negatively regulating the Nrf2/HO-1 signaling pathway
... in Nrf2 and endoplasmic reticulum (ER) stress may consti- tute early events in AD pathogenesis, which provides a new strategy to study AD ...regulate Nrf2 in breast carcinogenesis ...regulating ...
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Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001
... response pathway against anticancer drug-induced cytotoxic ...of Nrf2 and the activation of expression of its downstream enzymes HO-1 and NQO1 in tumor ...intrinsic Nrf2 expression by ...
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Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
... models. HO-1 is an endogenous antioxidant enzyme upregulated in cerebral ischemia and catalyzes the conversion of heme to carbon monox- ide and ...biliverdin. HO-1 expression is controlled and ...
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Original Article Effects of that ATRA inhibits Nrf2-ARE pathway on glial cells activation after intracerebral hemorrhage
... the Nrf2-ARE signaling pathway plays a neruo-protective role in glia cell, however, the mechanism was also ...on Nrf2-ARE pathway in intracerebral hemorrhage (ICH), and investigate the ...of ...
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Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway
... activate Nrf2 and induce NADPH quinone oxidoreduc- tase-1 expression than parent DHA (53), suggesting that the more efficacious effects of n-3 PUFA-enriched A-CRLPs reported here could involve the actions ...
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Houttuynia cordata Thunb. and its bioactive compound 2-undecanone significantly suppress benzo(a)pyrene-induced lung tumorigenesis by activating the Nrf2-HO-1/NQO-1 signaling pathway
... Worldwide, lung cancer remains the most frequently di- agnosed cancer and the leading cause of cancer-related death, resulting in large social and economic burdens [1]. Many advanced treatments, including medical, ...
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Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells
... pharmacological Nrf2 activator, SFN, which has been shown to exert cellu- lar protection by promoting the nuclear translocation of Nrf2 and thus triggering intracellular defence responses to oxidative ...
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<p>Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling</p>
... In this study, a rat model of AP was successfully estab- lished by injecting with sodium taurocholate into the pan- creatic duct and obvious lung injury was developed. The proin fl ammatory cytokines TNF- α , IL-1 ...
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