Nrf2 pathway
Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
... Keap1-Nrf2 pathway is an emerging target for PC prevention and therapy. Indeed, Nrf2 plays an either tumor-suppressive or promoting function in PC, which depends on the developmental stages of the ...
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Protective effect of Citrus macroptera fruit pulp juice rendering Nrf2-pathway against cisplatin-induced genotoxicity
... (Nrf2) pathway is one of the most important mechanisms in a cell which protects from oxidative stress generated from endogenous or exogenous chemical stressors (Jin et ...of Nrf2 gene into the ...
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Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
... (Abcam), Nrf2 (Santa Cruz Biotechnology or CST), Keap1 (CST), phospho-Akt (Ser473; CST), phospho-ERK1/2 (Thr202/Tyr204; CST), phospho-GSK3α/β (Ser21/9; CST), and β-actin (CST), GAPDH (CST), or histone H3 (CST) for ...
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The Pharmacological Manipulation of the Nrf2 Pathway and Its Therapeutic Significance
... of Nrf2, the role of this transcription factor has been highlighted in the maintenance of cellular homeostasis by combating toxic insults generated intrinsically and extrinsically (Itoh et ...addition, Nrf2 ...
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Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges
... the upregulation of NF-κB, thereby leading to concomitant downregulation of pro- inflammatory cytokine levels (IL-1, IL-2, IL-18 and TNF- α) and cell adhesion molecules (P-selectin and E-selectin) [119]. Also, repeated ...
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Evaluation of UHRF1 expression in pancreatic cancer
... of NRF2 by targeting UHRF1 by siRNA in pancreatic cancer cells) makes UHRF1 an interesting drug target in pancreatic ...targeting NRF2 by siRNA causes a decrease in proliferation and an increase in cell ...
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The stress signalling pathway nuclear factor E2-related factor 2 is activated in the liver of sows during lactation
... of Nrf2 pathway in the liver of sows we determined tran- script levels of several known Nrf2 target genes in the liver ...known Nrf2 target genes, UGT1A1, HO-1, NQO1, GPX1, PRDX6, TXNRD1, and ...
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β Cell–specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity
... factor Nrf2 (nuclear fac- tor-erythroid 2 p45-related factor 2, also known as Nfe2l2) and Nrf2 target genes that are an important defense against oxidative stress ...the Nrf2 pathway was ...
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Differential expression of the Nrf2 linked genes in pediatric septic shock
... of Nrf2-linked genes by performing a focused analysis of a ...blood–derived, Nrf2-linked genes would be differentially regulated between pediatric patients with septic shock within the first 24 h of ...
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<p>Identification of Pannexin 2 as a Novel Marker Correlating with Ferroptosis and Malignant Phenotypes of Prostate Cancer Cells</p>
... 6A). Nrf2 pathway plays a crucial role in oxidative stress, especially the Nrf2 ...reduce Nrf2 mRNA and protein expressions, and the downstream gene expressions (HO-1 and FTH1) (Figure 6B and ...
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Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver
... After male KM mice were treated with a series of doses of Sch B (25.0, 50.0, and 100.0 mg/kg) for 21 days, all of the main five CYP450s, (CYP1A2/2C9/2D6/2E1/3A4) activities in livers of mice from Sch B-treated groups ...
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Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
... of Nrf2 expression in microglia cultures. In fact, stimulation of the Nrf2 pathway has been shown to inhibit microglial activation [55, 56] supporting the anti-inflammatory capacity of Nrf2 ...
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Original Article -acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway
... endogenous Nrf2/HO-1 antioxidant path- way can confer protection against liver ...the Nrf2 pathway presents an attrac- tive opportunity since this intrinsic cellular pathway can be dynamically ...
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Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
... canonical Nrf2 signaling, pharmacologic acti- vation of the Nrf2 pathway is myoprotective in a mouse model of dystrophinopathy [38], while Nrf2 deletion enhances muscle pathology in a mouse ...
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<p>Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes</p>
... the Nrf2 pathway. (A) Protein expression of Nrf2, SOD-1and SOD-2 was investigated by Western blotting using antibodies against the indicated protein, and β-actin was used as a control for equal ...of ...
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Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells
... pharmacological Nrf2 activator, SFN, which has been shown to exert cellu- lar protection by promoting the nuclear translocation of Nrf2 and thus triggering intracellular defence responses to oxidative ...
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Acrolein exposure suppresses antigen-induced pulmonary inflammation
... the Nrf2 pathway, indicated by accumulation of Nrf2, increased alkylation of Keap1, and induction of Nrf2-target genes such as ...of Nrf2 and anti-inflammatory gene expression, and ...
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The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
... lung NRF2 expression and GSH metab- olism as well as elevated protein carbonyl content are recognized as central features of many human chronic lung diseases, including idiopathic pulmonary fibrosis, cystic ...
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Inhibition of Nrf2/HO 1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis
... circumstances, Nrf2 is mainly present in the cytoplasm; however, when the level of ROS is elevated, the transcription of antioxidative stress proteins, including HO-1, is enhanced by Nrf2 [35, ...factor ...
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Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells
... The Nrf2-Keap1-ARE signaling system is central to the induction of phase 2 genes by electrophiles and antioxi- dants ...vate Nrf2 and translocated into the nucleus, with increased expression of NQO1 and ...
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