Nrf2/ROS
MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma
... Notch signaling is a critical regulator in embryo devel- opment through the modulation of cell–cell communi- cation [24]. Increasing evidences indicate that Notch signaling plays important roles in cancer development and ...
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ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell
... induced ROS was also ob- served in our work, as shown by the fact that ROS scavenger NAC treatment abolished 5cGy radiation induced ...induced ROS by LDIR leads to the protection against high dose ...
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Aged Garlic Extract Reduces ROS Production and Cell Death Induced by 6 Hydroxydopamine through Activation of the Nrf2 ARE Pathway in SH SY5Y Cells
... liberate Nrf2. Nrf2 then translocates and accumulates in nucleus and activates the Nrf2-ARE path- way ...of Nrf2 and stimulate the production of antioxidant en- zymes such as NQO1 and HO-1 ...
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Disulfiram targeting lymphoid malignant cell lines via ROS JNK activation as well as Nrf2 and NF kB pathway inhibition
... by ROS [3]. Nrf2 is a transcription factor that plays a vital role in activating antioxidant response which abolishes ROS activity, detoxifies harmful chemi- cals and eventually protects cancer cells ...
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Heracleum moellendorffii roots inhibit the production of pro inflammatory mediators through the inhibition of NF κB and MAPK signaling, and activation of ROS/Nrf2/HO 1 signaling in LPS stimulated RAW264 7 cells
... of Nrf2 [19, ...through ROS/Nrf2/HO-1 signaling activation [21]. Thus, the effect of ROS on Nrf2/ HO-1 signaling activation by HM-R was ...nuclear Nrf2 level. These results ...
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Combined inhibition of autophagy and Nrf2 signaling augments bortezomib-induced apoptosis by increasing ROS production and ER stress in pancreatic cancer cells
... of ROS, which promotes oxidative stress ...that ROS can induce autophagy in response to chemotherapy-induced stress [21, ...pathway. Nrf2 is a critical regulator of intracellular antioxidants and ...
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Sulforaphane Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Migration via Suppression of NOX4/ROS/Nrf2 Signaling
... Angiotensin II (Ang II) is involved in the pathogenic progress of cardiovascular diseases via the promotion of abnormal proliferation and migration of human vascular smooth muscle cells (HVSMCs). Sulforaphane (SFN) ...
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Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification
... manner. Nrf2 protein was upregulated and subsequently, its transcriptional activity was increased with greater DNA binding activity and transcription of target ...of Nrf2 led to suppression of PSC-CM ...
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Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease
... Intracellular ROS levels are regulated by an inducible antioxidant program that responds to cel- lular stressors and is largely correlated with the activa- tion of Nrf2, which regulates the expression of ...
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Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway
... tested the activity of CAT and SOD, two ROS scavenger enzymes. Our results showed that the activity of the two enzymes was inhibited by HG and palmitate and rescued by NaHS treatment (Fig. 6c). Because cl-casp 9 ...
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Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... Ischemic stroke is a primary cause of severe acquired disability worldwide [1]. Administration of the thrombolytic agent tissue plasminogen activator is still the only FDA-approved therapy for acute ischemic stroke [2, ...
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Role of Nrf2 in Host Defense against Influenza Virus in Cigarette Smoke-Exposed Mice
... strong Nrf2 staining was observed for alveolar macrophages but not for bronchial epithelial cells after FluV infection of CS-exposed WT ...the Nrf2-mediated defense system acts mainly on macrophages in the ...
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Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis
... intracellular ROS in seawater- treated MLE-12 ...intracellular ROS in MLE-12 cells, which was decreased by Fer-1 treatment ...Lipid ROS accumulation is a typical feature of ferroptosis ...lipid ...
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<p>Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes</p>
... excess ROS can then lead to clear destruction of the cartilage matrix via several intracellular pathways, including cytokine receptors, receptor tyrosine kinases, receptor serine/threonine kinases and G protein ...
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Antioxidant Defense: Effects of an NRF2 ARE Polymorphism on the Activation of Phase II Enzymes
... significant NRF2 induction in response to hyperoxia, BHT and LPS (Chan 1999; Cho 2002; Rushworth ...of NRF2 induction and downstream activity as compared to hyperoxia and ...in NRF2 variant cells ...
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Nrf2 Activates Augmenter of Liver Regeneration (ALR) via Antioxidant Response Element and Links Oxidative Stress to Liver Regeneration
... of Nrf2 in toxin detoxification and cancer prevention have been well es- tablished, and a novel function of Nrf2 in liver regeneration was demonstrated re- ...of ROS- detoxifying enzymes ...the ...
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Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia
... The cytotoxic effect of CDDP mainly resulted from the inhibition of DNA replication and the induction of apoptosis through the ROS pathway [29]. Therefore, an increase of antioxidant capacity may lead to CDDP ...
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Houttuynia cordata Thunb. and its bioactive compound 2-undecanone significantly suppress benzo(a)pyrene-induced lung tumorigenesis by activating the Nrf2-HO-1/NQO-1 signaling pathway
... B[a]P-induced excessive production of ROS, which re- sults in oxidative stress, can severely damage DNA structure and is a prerequisite for B[a]P-associated tumorigenesis [10–12]. It has been reported that DNA ...
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Anti TNF certolizumab pegol induces antioxidant response in human monocytes via reverse signaling
... Background: Anti TNF drugs have been widely used in rheumatoid arthritis (RA) but only 70 to 80 % of patients respond to this therapy. Exploring the mode of action of anti-TNF drugs remains important in order to improve ...
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Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression
... malondialdehyde, ROS, superoxide dismutase (SOD), oxidised and reduced glutathione, hydroxyproline, and overall collagen levels were identified in lung tissues using ...
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